PJA2

Details:

UniProt Entry: O43164
Gene: PJA2
Class: RING
Family: RING9
Protein length: 708
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>O43164
MSQYTEKEPA AMDQESGKAV WPKPAGGYQT ITGRRYGRRH AYVSFKPCMT RHERSLGRAG
DDYEVLELDD VPKENSSGSS PLDQVDSSLP SEPIFEKSET EIPTCGSALN QTTESSQSFV
AVHHSEEGRD TLGSSTNLHN HSEGEYIPGA CSASSVQNGI ALVHTDSYDP DGKHGEDNDH
LQLSAEVVEG SRYQESLGNT VFELENREAE AYTGLSPPVP SFNCEVRDEF EELDSVPLVK
SSAGDTEFVH QNSQEIQRSS QDEMVSTKQQ NNTSQERQTE HSPEDAACGP GHICSEQNTN
DREKNHGSSP EQVVRPKVRK LISSSQVDQE TGFNRHEAKQ RSVQRWREAL EVEESGSDDL
LIKCEEYDGE HDCMFLDPPY SRVITQRETE NNQMTSESGA TAGRQEVDNT FWNGCGDYYQ
LYDKDEDSSE CSDGEWSASL PHRFSGTEKD QSSSDESWET LPGKDENEPE LQSDSSGPEE
ENQELSLQEG EQTSLEEGEI PWLQYNEVNE SSSDEGNEPA NEFAQPAFML DGNNNLEDDS
SVSEDLDVDW SLFDGFADGL GVAEAISYVD PQFLTYMALE ERLAQAMETA LAHLESLAVD
VEVANPPASK ESIDGLPETL VLEDHTAIGQ EQCCPICCSE YIKDDIATEL PCHHFFHKPC
VSIWLQKSGT CPVCRRHFPP AVIEASAAPS SEPDPDAPPS NDSIAEAP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
596	682	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
634	674	Domain	Zinc finger, RING-type	IPR001841	SM00184
634	675	Domain	Zinc finger, RING-type	IPR001841	PF13639
634	675	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006954	inflammatory response	Biological Process	IMP	PMID:28471450
GO:0007616	long-term memory	Biological Process	ISS	GO_REF:0000024
GO:0010738	regulation of protein kinase A signaling	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	Biological Process	IMP	PMID:28471450
GO:0043030	regulation of macrophage activation	Biological Process	IMP	PMID:28471450
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:33934390
GO:0045087	innate immune response	Biological Process	IMP	PMID:28471450
GO:0046330	positive regulation of JNK cascade	Biological Process	IMP	PMID:28471450
GO:1900745	positive regulation of p38MAPK cascade	Biological Process	IMP	PMID:28471450
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0036064	ciliary basal body	Cellular Component	ISS	PMID:33934390
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0000139	Golgi membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000043
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0014069	postsynaptic density	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0034451	centriolar satellite	Cellular Component	IDA	PMID:33934390
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:21423175
GO:0005515	protein binding	Molecular Function	IPI	PMID:28471450
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0034236	protein kinase A catalytic subunit binding	Molecular Function	IMP	PMID:21423175
GO:0034237	protein kinase A regulatory subunit binding	Molecular Function	IMP	PMID:21423175
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


P31323	KAP3	Yes	Yes	No	No	—	No	E3-specific
P31321	KAP1	Yes	Yes	No	No	—	No	E3-specific
Q8IVT5	KSR1	Yes	No	No	No	—	No	E3-specific
Q9Y4C4	MFHA1	Yes	No	No	No	—	No	E3-specific
O43164	PJA2	Yes	Yes	No	No	—	No	E3-specific
P10644	KAP0	Yes	Yes	No	No	—	No	E3-specific
P13861	KAP2	Yes	Yes	No	No	24083380	EBI-9073957	E3-specific

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