MEFV

Details:

UniProt Entry: O15553
Gene: MEFV
Class: RING
Family: RING5
Protein length: 781
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2mpc, 2wl1, 4cg4

Protein Sequence ▾

>O15553
MAKTPSDHLL STLEELVPYD FEKFKFKLQN TSVQKEHSRI PRSQIQRARP VKMATLLVTY
YGEEYAVQLT LQVLRAINQR LLAEELHRAA IQEYSTQENG TDDSAASSSL GENKPRSLKT
PDHPEGNEGN GPRPYGGGAA SLRCSQPEAG RGLSRKPLSK RREKASEGLD AQGKPRTRSP
ALPGGRSPGP CRALEGGQAE VRLRRNASSA GRLQGLAGGA PGQKECRPFE VYLPSGKMRP
RSLEVTISTG EKAPANPEIL LTLEEKTAAN LDSATEPRAR PTPDGGASAD LKEGPGNPEH
SVTGRPPDTA ASPRCHAQEG DPVDGTCVRD SCSFPEAVSG HPQASGSRSP GCPRCQDSHE
RKSPGSLSPQ PLPQCKRHLK QVQLLFCEDH DEPICLICSL SQEHQGHRVR PIEEVALEHK
KKIQKQLEHL KKLRKSGEEQ RSYGEEKAVS FLKQTEALKQ RVQRKLEQVY YFLEQQEHFF
VASLEDVGQM VGQIRKAYDT RVSQDIALLD ALIGELEAKE CQSEWELLQD IGDILHRAKT
VPVPEKWTTP QEIKQKIQLL HQKSEFVEKS TKYFSETLRS EMEMFNVPEL IGAQAHAVNV
ILDAETAYPN LIFSDDLKSV RLGNKWERLP DGPQRFDSCI IVLGSPSFLS GRRYWEVEVG
DKTAWILGAC KTSISRKGNM TLSPENGYWV VIMMKENEYQ ASSVPPTRLL IKEPPKRVGI
FVDYRVGSIS FYNVTARSHI YTFASCSFSG PLQPIFSPGT RDGGKNTAPL TICPVGGQGP
D

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	92	Domain	DAPIN domain	IPR004020	PS50824
1	91	Homologous_superfamily	Death-like domain superfamily	IPR011029	SSF47986
3	97	Homologous_superfamily	Death-like domain superfamily	IPR011029	G3DSA:1.10.533.10
5	88	Domain	DAPIN domain	IPR004020	SM01289
8	84	Domain	DAPIN domain	IPR004020	PF02758
370	412	Domain	B-box-type zinc finger	IPR000315	SM00336
370	412	Domain	B-box-type zinc finger	IPR000315	PS50119
371	412	Domain	B-box-type zinc finger	IPR000315	PF00643
580	775	Domain	B30.2/SPRY domain	IPR001870	PS50188
586	776	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
594	775	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
596	613	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
597	649	Domain	SPRY-associated	IPR006574	SM00589
600	648	Domain	SPRY-associated	IPR006574	PF13765
613	630	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
635	659	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
650	776	Domain	SPRY domain	IPR003877	SM00449
653	761	Domain	SPRY domain	IPR003877	PF00622
665	678	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
709	733	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
740	758	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006954	inflammatory response	Biological Process	IEA	GO_REF:0000043
GO:0032731	positive regulation of interleukin-1 beta production	Biological Process	IEA	GO_REF:0000117
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000043
GO:0050727	regulation of inflammatory response	Biological Process	IEA	GO_REF:0000117
GO:0051707	response to other organism	Biological Process	IEA	GO_REF:0000117
GO:0002221	pattern recognition receptor signaling pathway	Biological Process	NAS	PMID:29196474
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0010508	positive regulation of autophagy	Biological Process	IDA	PMID:26347139
GO:0032651	regulation of interleukin-1 beta production	Biological Process	IMP	PMID:27030597
GO:0032691	negative regulation of interleukin-1 beta production	Biological Process	IMP	PMID:20041150
GO:0032695	negative regulation of interleukin-12 production	Biological Process	IMP	PMID:20041150
GO:0034341	response to type II interferon	Biological Process	IDA	PMID:26347139
GO:0050728	negative regulation of inflammatory response	Biological Process	IMP	PMID:16403826
GO:0050729	positive regulation of inflammatory response	Biological Process	ISO	GO_REF:0000114
GO:0070269	pyroptotic inflammatory response	Biological Process	NAS	PMID:29196474
GO:0071641	negative regulation of macrophage inflammatory protein 1 alpha production	Biological Process	IMP	PMID:20041150
GO:1900016	negative regulation of cytokine production involved in inflammatory response	Biological Process	IMP	PMID:26347139
GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	Biological Process	IMP	PMID:26347139
GO:1904270	pyroptosome complex assembly	Biological Process	IDA	PMID:27030597
GO:0001726	ruffle	Cellular Component	IEA	GO_REF:0000044
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005776	autophagosome	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005874	microtubule	Cellular Component	IEA	GO_REF:0000043
GO:0030027	lamellipodium	Cellular Component	IEA	GO_REF:0000044
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IBA	GO_REF:0000033
GO:0005875	microtubule associated complex	Cellular Component	IDA	PMID:11468188
GO:0061702	canonical inflammasome complex	Cellular Component	IPI	PMID:16037825
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:11498534
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:17964261
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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