R113A

Details:

UniProt Entry: O15541
Gene: RNF113A
Class: RING
Family: RING4
Protein length: 343
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 5z56, 5z58, 6ff4, 6ff7, 7dvq

Protein Sequence ▾

>O15541
MAEQLSPGKA VDQVCTFLFK KPGRKGAAGR RKRPACDPEP GESGSSSDEG CTVVRPEKKR
VTHNPMIQKT RDSGKQKAAY GDLSSEEEEE NEPESLGVVY KSTRSAKPVG PEDMGATAVY
ELDTEKERDA QAIFERSQKI QEELRGKEDD KIYRGINNYQ KYMKPKDTSM GNASSGMVRK
GPIRAPEHLR ATVRWDYQPD ICKDYKETGF CGFGDSCKFL HDRSDYKHGW QIERELDEGR
YGVYEDENYE VGSDDEEIPF KCFICRQSFQ NPVVTKCRHY FCESCALQHF RTTPRCYVCD
QQTNGVFNPA KELIAKLEKH RATGEGGASD LPEDPDEDAI PIT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
7	324	Family	Pre-mRNA-splicing factor CWC24-like	IPR039971	PTHR12930
193	228	Homologous_superfamily	Zinc finger, CCCH-type superfamily	IPR036855	SSF90229
196	224	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
196	223	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
197	222	Domain	Zinc finger, CCCH-type	IPR000571	PF00642
260	319	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
262	299	Domain	Zinc finger, RING-type	IPR001841	SM00184
262	300	Domain	Zinc finger, RING-type	IPR001841	PS50089
277	286	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IDA	PMID:29360106
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006397	mRNA processing	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0008380	RNA splicing	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0034247	snoRNA splicing	Biological Process	IBA	GO_REF:0000033
GO:0070100	negative regulation of chemokine-mediated signaling pathway	Biological Process	IMP	PMID:28978524
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0016607	nuclear speck	Cellular Component	IEA	GO_REF:0000044
GO:0005681	spliceosomal complex	Cellular Component	IEA	GO_REF:0000043
GO:0005684	U2-type spliceosomal complex	Cellular Component	IBA	GO_REF:0000033
GO:0071005	U2-type precatalytic spliceosome	Cellular Component	IDA	PMID:29360106
GO:0005515	protein binding	Molecular Function	IPI	PMID:22365833
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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