SOCS1

Details:

UniProt Entry: O15524
Gene: SOCS1
Class: Other E3 Components
Family: Receptor
Protein length: 211
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O15524
MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS
HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT FLVRDSRQRN CFFALSVKMA
SGPTSIRVHF QAGRFHLDGS RESFDCLFEL LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ
RIVATVGREN LARIPLNPVL RDYLSSFPFQ I

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
51	172	Homologous_superfamily	SH2 domain superfamily	IPR036860	G3DSA:3.30.505.10
68	165	Domain	SOCS1, SH2 domain	IPR035861	cd10382
71	172	Homologous_superfamily	SH2 domain superfamily	IPR036860	SSF55550
77	160	Domain	SH2 domain	IPR000980	SM00252
79	154	Domain	SH2 domain	IPR000980	PF00017
79	174	Domain	SH2 domain	IPR000980	PS50001
161	210	Domain	SOCS box domain	IPR001496	PS50225
165	208	Domain	SOCS box domain	IPR001496	SM00253
165	210	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235
171	207	Domain	SOCS box domain	IPR001496	SM00969

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001817	regulation of cytokine production	Biological Process	IEA	GO_REF:0000107
GO:0007259	cell surface receptor signaling pathway via JAK-STAT	Biological Process	IEA	GO_REF:0000107
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0045444	fat cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0046425	regulation of receptor signaling pathway via JAK-STAT	Biological Process	IEA	GO_REF:0000107
GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	Biological Process	IEA	GO_REF:0000107
GO:0046627	negative regulation of insulin receptor signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0071230	cellular response to amino acid stimulus	Biological Process	IEA	GO_REF:0000107
GO:0009968	negative regulation of signal transduction	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030225	macrophage differentiation	Biological Process	IMP	PMID:32634427
GO:0032502	developmental process	Biological Process	IEA	GO_REF:0000117
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0043377	negative regulation of CD8-positive, alpha-beta T cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0045591	positive regulation of regulatory T cell differentiation	Biological Process	IMP	PMID:22387553
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	TAS	PMID:9202126
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-6785860
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0004860	protein kinase inhibitor activity	Molecular Function	TAS	PMID:9202125
GO:0005126	cytokine receptor binding	Molecular Function	IBA	GO_REF:0000033
GO:0005159	insulin-like growth factor receptor binding	Molecular Function	IPI	PMID:9727029
GO:0005515	protein binding	Molecular Function	IPI	PMID:16273093
GO:0019210	kinase inhibitor activity	Molecular Function	ISS	GO_REF:0000024
GO:0019901	protein kinase binding	Molecular Function	IPI	PMID:9727029

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