TIF1A

>O15164
MEVAVEKAVA AAAAASAAAS GGPSAAPSGE NEAESRQGPD SERGGEAARL NLLDTCAVCH
QNIQSRAPKL LPCLHSFCQR CLPAPQRYLM LPAPMLGSAE TPPPVPAPGS PVSGSSPFAT
QVGVIRCPVC SQECAERHII DNFFVKDTTE VPSSTVEKSN QVCTSCEDNA EANGFCVECV
EWLCKTCIRA HQRVKFTKDH TVRQKEEVSP EAVGVTSQRP VFCPFHKKEQ LKLYCETCDK
LTCRDCQLLE HKEHRYQFIE EAFQNQKVII DTLITKLMEK TKYIKFTGNQ IQNRIIEVNQ
NQKQVEQDIK VAIFTLMVEI NKKGKALLHQ LESLAKDHRM KLMQQQQEVA GLSKQLEHVM
HFSKWAVSSG SSTALLYSKR LITYRLRHLL RARCDASPVT NNTIQFHCDP SFWAQNIINL
GSLVIEDKES QPQMPKQNPV VEQNSQPPSG LSSNQLSKFP TQISLAQLRL QHMQQQVMAQ
RQQVQRRPAP VGLPNPRMQG PIQQPSISHQ QPPPRLINFQ NHSPKPNGPV LPPHPQQLRY
PPNQNIPRQA IKPNPLQMAF LAQQAIKQWQ ISSGQGTPST TNSTSSTPSS PTITSAAGYD
GKAFGSPMID LSSPVGGSYN LPSLPDIDCS STIMLDNIVR KDTNIDHGQP RPPSNRTVQS
PNSSVPSPGL AGPVTMTSVH PPIRSPSASS VGSRGSSGSS SKPAGADSTH KVPVVMLEPI
RIKQENSGPP ENYDFPVVIV KQESDEESRP QNANYPRSIL TSLLLNSSQS STSEETVLRS
DAPDSTGDQP GLHQDNSSNG KSEWLDPSQK SPLHVGETRK EDDPNEDWCA VCQNGGELLC
CEKCPKVFHL SCHVPTLTNF PSGEWICTFC RDLSKPEVEY DCDAPSHNSE KKKTEGLVKL
TPIDKRKCER LLLFLYCHEM SLAFQDPVPL TVPDYYKIIK NPMDLSTIKK RLQEDYSMYS
KPEDFVADFR LIFQNCAEFN EPDSEVANAG IKLENYFEEL LKNLYPEKRF PKPEFRNESE
DNKFSDDSDD DFVQPRKKRL KSIEERQLLK

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
47	160	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
56	130	Domain	Zinc finger, RING-type	IPR001841	SM00184
56	131	Domain	Zinc finger, RING-type	IPR001841	PS50089
73	82	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
158	211	Domain	B-box-type zinc finger	IPR000315	PS50119
158	205	Domain	B-box-type zinc finger	IPR000315	SM00336
218	259	Domain	B-box-type zinc finger	IPR000315	SM00336
218	259	Domain	B-box-type zinc finger	IPR000315	PS50119
221	257	Domain	B-box-type zinc finger	IPR000315	PF00643
266	392	Domain	B-box, C-terminal	IPR003649	SM00502
820	876	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
823	883	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
826	873	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
828	871	Domain	Zinc finger, PHD-type	IPR001965	SM00249
829	871	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
829	870	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
885	1016	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	G3DSA:1.20.920.10
888	1007	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	SSF47370
901	1006	Domain	Bromodomain	IPR001487	SM00297
908	988	Domain	Bromodomain	IPR001487	PF00439
918	979	Conserved_site	Bromodomain, conserved site	IPR018359	PS00633
932	987	Domain	Bromodomain	IPR001487	PS50014
932	948	Domain	Bromodomain	IPR001487	PR00503
968	987	Domain	Bromodomain	IPR001487	PR00503

GO term	Name	Ontology	Evidence	Reference
GO:0050673	epithelial cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0010628	positive regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0050680	negative regulation of epithelial cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0055074	calcium ion homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0070562	regulation of vitamin D receptor signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:1901796	regulation of signal transduction by p53 class mediator	Biological Process	IEA	GO_REF:0000107
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000108
GO:0006366	transcription by RNA polymerase II	Biological Process	TAS	PMID:9115274
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0031647	regulation of protein stability	Biological Process	IEA	GO_REF:0000107
GO:0042981	regulation of apoptotic process	Biological Process	IMP	PMID:19556538
GO:0043434	response to peptide hormone	Biological Process	IEA	GO_REF:0000120
GO:0071391	cellular response to estrogen stimulus	Biological Process	IDA	PMID:21164480
GO:0000785	chromatin	Cellular Component	IBA	GO_REF:0000033
GO:0000791	euchromatin	Cellular Component	IEA	GO_REF:0000107
GO:0001673	male germ cell nucleus	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005726	perichromatin fibrils	Cellular Component	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1839031
GO:0031981	nuclear lumen	Cellular Component	IEA	GO_REF:0000117
GO:0002039	p53 binding	Molecular Function	IEA	GO_REF:0000107
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003682	chromatin binding	Molecular Function	IEA	GO_REF:0000107
GO:0003713	transcription coactivator activity	Molecular Function	IEA	GO_REF:0000107
GO:0004672	protein kinase activity	Molecular Function	IEA	GO_REF:0000107
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0005102	signaling receptor binding	Molecular Function	TAS	PMID:9115274
GO:0005515	protein binding	Molecular Function	IPI	PMID:19556538
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016922	nuclear receptor binding	Molecular Function	IEA	GO_REF:0000107
GO:0034056	estrogen response element binding	Molecular Function	IDA	PMID:21164480
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000107
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0140118	histone H3K23ac reader activity	Molecular Function	IDA	PMID:21164480

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL3774575	ChEMBL	8.89	4C1	—	CCCOc1cc(OCCCCN(C)C)cc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3775853	ChEMBL	7.37	—	—	CCCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL4436408	ChEMBL	6.04	67B	—	CN(C)C(=O)c1cccc(-c2cn(C)c(=O)c3[nH]ccc23)c1
E3 Binder	CHEMBL3775132	ChEMBL	6.96	—	—	CC(C)COc1cccc(Oc2cc3c(cc2NS(=O)(=O)C2CC2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3774452	ChEMBL	6.8	—	—	CCCCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)c(C)n2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3774766	ChEMBL	7.89	—	—	CCCOc1cc(OCCCCCCN)cc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3775901	ChEMBL	8.0	—	—	CCCOc1cc(OCCCCCCN)cc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)cn2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3774638	ChEMBL	6.8	—	—	CCCOc1cc(OCCCCCCNC(=O)OC(C)(C)C)cc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)cn2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3774770	ChEMBL	7.22	—	—	CCCOc1cc(OCCCCCCO)cc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)cn2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3775348	ChEMBL	7.96	—	—	CCCOc1cc(OCCCCCN)cc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)cn2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3774933	ChEMBL	8.08	—	—	CCCOc1cc(OCCCCN)cc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3775251	ChEMBL	8.1	—	—	CCCOc1cc(OCCCCN)cc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)cn2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3774542	ChEMBL	7.89	—	—	CCCOc1cc(OCCCN)cc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL5276376	ChEMBL	6.47	—	—	CCCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2cccc(C(=O)NCCOCCOCCOCC(=O)N[C@@H](C(=O)N4C[C@@H](O)C[C@@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)c2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3775073	ChEMBL	7.28	—	—	CCCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)c(C)n2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3774653	ChEMBL	6.75	—	—	CCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)c(C)n2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL4451080	ChEMBL	6.38	—	—	COC(=O)c1ccc2nc(-c3cn(S(=O)(=O)c4ccc(C)cc4)c4ccccc34)c(NCc3ccccc3)n2c1
E3 Binder	CHEMBL4470369	ChEMBL	6.51	—	—	COC(=O)c1ccc2nc(-c3nc[nH]c3C)c(NCCN3CCOCC3)n2c1
E3 Binder	CHEMBL3774529	ChEMBL	6.89	—	—	COCCCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2cn(C)c(C)n2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL13883	ChEMBL	6.79	V55	—	COc1cc(C=O)ccc1O
E3 Binder	CHEMBL5196972	ChEMBL	6.01	—	—	COc1ccc(C2CC2)cc1S(=O)(=O)Nc1ccc2c(c1)CCN2C(C)=O
E3 Binder	CHEMBL350966	ChEMBL	6.66	—	—	COc1ccc(C=O)c(O)c1
E3 Binder	CHEMBL4452179	ChEMBL	6.23	—	—	COc1ccc(CCNc2c(-c3cn(S(=O)(=O)c4ccc(C)cc4)c4ccccc34)nc3ccccn23)cc1OC
E3 Binder	CHEMBL4448530	ChEMBL	6.09	—	—	COc1ccc(Nc2c(-c3c[nH]c(C)n3)nc3ccc(Br)cn23)cc1
E3 Binder	CHEMBL4446283	ChEMBL	6.45	—	—	COc1ccc(Nc2c(-c3nc[nH]c3C)nc3ccccn23)cc1
E3 Binder	CHEMBL3769965	ChEMBL	6.65	4QH	—	COc1ccc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)cc1
E3 Binder	CHEMBL3770456	ChEMBL	6.11	—	—	COc1ccc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)cc2)n(C)c(=O)n3C)cc1
E3 Binder	CHEMBL3770259	ChEMBL	6.14	4AE	—	COc1ccc(Oc2cc3c(cc2NS(=O)(=O)c2ccccc2)n(C)c(=O)n3C)cc1
E3 Binder	CHEMBL3774883	ChEMBL	6.57	—	—	COc1ccc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCCCCN(C)C)c2)n(C)c(=O)n3C)cc1OC
E3 Binder	CHEMBL3775263	ChEMBL	6.85	4BJ	—	COc1ccc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCc4ccccc4)c2)n(C)c(=O)n3C)cc1OC
E3 Binder	CHEMBL3771002	ChEMBL	6.13	—	—	COc1ccc(S(=O)(=O)Nc2cc3c(cc2Oc2ccccc2)n(C)c(=O)n3C)cc1
E3 Binder	CHEMBL3769887	ChEMBL	6.32	—	—	COc1ccc(S(=O)(=O)Nc2cc3c(cc2Oc2ccccc2)n(C)c(=O)n3C)cc1OC
E3 Binder	CHEMBL4461534	ChEMBL	6.13	—	—	Cc1[nH]cnc1-c1nc2ccccn2c1NCCN1CCOCC1
E3 Binder	CHEMBL4467793	ChEMBL	6.8	—	—	Cc1cccc2c(C=O)c[nH]c12
E3 Binder	CHEMBL3774507	ChEMBL	7.24	4BK	—	Cc1nc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCC(C)C)c2)n(C)c(=O)n3C)cn1C
E3 Binder	CHEMBL3775640	ChEMBL	6.57	—	—	Cc1nc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCc4ccccc4)c2)n(C)c(=O)n3C)cn1C
E3 Binder	CHEMBL4580867	ChEMBL	6.52	—	—	Cc1nc[nH]c1-c1nc2ccc(C(=O)NN)cn2c1NCCN1CCOCC1
E3 Binder	CHEMBL543846	ChEMBL	6.65	—	—	Cc1ncc(CO)c(C=O)c1O.Cl
E3 Binder	CHEMBL2229659	ChEMBL	6.74	—	—	Cn1cccc1C=O
E3 Binder	CHEMBL3775689	ChEMBL	7.0	—	—	Cn1cnc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCC4CCOC4)c2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3775286	ChEMBL	6.66	—	—	Cn1cnc(S(=O)(=O)Nc2cc3c(cc2Oc2cccc(OCc4ccccc4)c2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL18620	ChEMBL	6.87	MFW	—	O=C1CCCC1
E3 Binder	CHEMBL18737	ChEMBL	6.78	—	—	O=C1CCCCCCC1
E3 Binder	CHEMBL4572394	ChEMBL	6.88	—	—	O=Cc1ccc(N2CCCC2)cc1
E3 Binder	CHEMBL4592980	ChEMBL	6.78	—	—	O=Cc1cccc(-c2ccc(C(=O)O)cc2)c1
E3 Binder	CHEMBL108925	ChEMBL	6.66	—	—	O=Cc1ccccc1O