AREL1

Details:

UniProt Entry: O15033
Gene: AREL1
Class: HECT
Family: HECT1
Protein length: 823
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 6jx5, 6loh

Protein Sequence ▾

>O15033
MFYVIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE
PNSNVVKVAF TVRKAGRYEI TVKLGGLNVA YSPYYKIFQP GMVVPSKTKI VCHFSTLVLT
CGQPHTLQIV PRDEYDNPTN NSMSLRDEHN YTLSIHELGP QEEESTGVSF EKSVTSNRQT
FQVFLRLTLH SRGCFHACIS YQNQPINNGE FDIIVLSEDE KNIVERNVST SGVSIYFEAY
LYNATNCSST PWHLPPMHMT SSQRRPSTAV DEEDEDSPSE CHTPEKVKKP KKVYCYVSPK
QFSVKEFYLK IIPWRLYTFR VCPGTKFSYL GPDPVHKLLT LVVDDGIQPP VELSCKERNI
LAATFIRSLH KNIGGSETFQ DKVNFFQREL RQVHMKRPHS KVTLKVSRHA LLESSLKATR
NFSISDWSKN FEVVFQDEEA LDWGGPRREW FELICKALFD TTNQLFTRFS DNNQALVHPN
PNRPAHLRLK MYEFAGRLVG KCLYESSLGG AYKQLVRARF TRSFLAQIIG LRMHYKYFET
DDPEFYKSKV CFILNNDMSE MELVFAEEKY NKSGQLDKVV ELMTGGAQTP VTNANKIFYL
NLLAQYRLAS QVKEEVEHFL KGLNELVPEN LLAIFDENEL ELLMCGTGDI SVSDFKAHAV
VVGGSWHFRE KVMRWFWTVV SSLTQEELAR LLQFTTGSSQ LPPGGFAALC PSFQIIAAPT
HSTLPTAHTC FNQLCLPTYD SYEEVHRMLQ LAISEGCEGF GML

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
52	158	Repeat	Filamin/ABP280 repeat-like	IPR017868	PS50194
54	154	Repeat	Filamin/ABP280 repeat-like	IPR017868	PF00630
54	162	Homologous_superfamily	Immunoglobulin-like fold	IPR013783	G3DSA:2.60.40.10
67	172	Homologous_superfamily	Immunoglobulin E-set	IPR014756	SSF81296
449	816	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
464	821	Domain	HECT domain	IPR000569	cd00078
481	823	Domain	HECT domain	IPR000569	SM00119
483	823	Domain	HECT domain	IPR000569	PS50237
513	822	Domain	HECT domain	IPR000569	PF00632

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0043066	negative regulation of apoptotic process	Biological Process	IBA	GO_REF:0000033
GO:0050727	regulation of inflammatory response	Biological Process	ISS	GO_REF:0000024
GO:0070979	protein K11-linked ubiquitination	Biological Process	IDA	PMID:25752577
GO:1990390	protein K33-linked ubiquitination	Biological Process	IDA	PMID:25752577
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:23479728
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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