UB2L6

Details:

UniProt Entry: O14933
Gene: UBE2L6
Class: Other E3 Components
Family: E2
Protein length: 153
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O14933
MMASMRVVKE LEDLQKKPPP YLRNLSSDDA NVLVWHALLL PDQPPYHLKA FNLRISFPPE
YPFKPPMIKF TTKIYHPNVD ENGQICLPII SSENWKPCTK TCQVLEALNV LVNRPNIREP
LRMDLADLLT QNPELFRKNA EEFTLRFGVD RPS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	153	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
2	147	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	SSF54495
2	149	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PS50127
4	144	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	cd00195
6	143	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PF00179
75	90	Active_site	Ubiquitin-conjugating enzyme, active site	IPR023313	PS00183

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0032446	protein modification by small protein conjugation	Biological Process	IEA	GO_REF:0000117
GO:0019941	modification-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0032020	ISG15-protein conjugation	Biological Process	IEA	GO_REF:0000107
GO:0045087	innate immune response	Biological Process	IDA	PMID:28724761
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0036211	protein modification process	Biological Process	TAS	PMID:9153201
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IC	PMID:16009940
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-5653754
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1169394
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019787	ubiquitin-like protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	PMID:9153201
GO:0005515	protein binding	Molecular Function	IPI	PMID:10085091
GO:0042296	ISG15 transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0043130	ubiquitin binding	Molecular Function	EXP	PMID:15485925
GO:0061631	ubiquitin conjugating enzyme activity	Molecular Function	IEA	GO_REF:0000003

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