BACH1

Details:

UniProt Entry: O14867
Gene: BACH1
Class: Other E3 Components
Family: Adaptor
Protein length: 736
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O14867
MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS VLAACSSYFH
SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK ENVDEVCKCV EFLSVHNIEE
SCFQFLKFKF LDSTADQQEC PRKKCFSSHC QKTDLKLSLL DQRDLETDEV EEFLENKNVQ
TPQCKLRRYQ GNAKASPPLQ DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR
TGESSVKDIH ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP
TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP LSGTDVQEKT
FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG FWSDICSTDT PCQMQLSPAV
AKDGSEQISQ KRSECPWLGI RISESPEPGQ RTFTTLSSVN CPFISTLSTE GCSSNLEIGN
DDYVSEPQQE PCPYACVISL GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND
FQSLLKMHKL TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL
KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF LISEKDKSTP
DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ MSTATSEQAG PAEQCRQSGG
ISDFCQQMTD KCTTDE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
5	135	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
7	127	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
24	127	Domain	BTB/POZ domain	IPR000210	PF00651
34	100	Domain	BTB/POZ domain	IPR000210	PS50097
34	130	Domain	BTB/POZ domain	IPR000210	SM00225
520	580	Homologous_superfamily	Transcription factor, Skn-1-like, DNA-binding domain superfamily	IPR008917	SSF47454
531	606	Domain	Basic leucine zipper domain, Maf-type	IPR004826	PF03131
551	621	Domain	BACH, basic leucine zipper (bZIP) domain	IPR043321	cd14719
553	619	Domain	Basic-leucine zipper domain	IPR004827	SM00338
562	577	Domain	Basic-leucine zipper domain	IPR004827	PS00036
562	620	Domain	Basic-leucine zipper domain	IPR004827	PS50217
566	609	Homologous_superfamily	Basic-leucine zipper domain superfamily	IPR046347	SSF57959

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006355	regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000002
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000002
GO:0010468	regulation of gene expression	Biological Process	IEA	GO_REF:0000117
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0006281	DNA repair	Biological Process	IMP	PMID:11301010
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	HDA	PMID:16780588
GO:0000785	chromatin	Cellular Component	ISA	GO_REF:0000113
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-9707523
GO:0005737	cytoplasm	Cellular Component	HDA	PMID:16791210
GO:0090575	RNA polymerase II transcription regulator complex	Cellular Component	ISS	GO_REF:0000114
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IEA	GO_REF:0000002
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IEA	GO_REF:0000107
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:20102225
GO:0020037	heme binding	Molecular Function	NAS	PMID:21555518
GO:0098531	ligand-modulated transcription factor activity	Molecular Function	IMP	PMID:21555518

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