ENC1

Details:

UniProt Entry: O14682
Gene: ENC1
Class: Other E3 Components
Family: Adaptor
Protein length: 589
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O14682
MSVSVHENRK SRASSGSINI YLFHKSSYAD SVLTHLNLLR QQRLFTDVLL HAGNRTFPCH
RAVLAACSRY FEAMFSGGLK ESQDSEVNFD NSIHPEVLEL LLDYAYSSRV IINEENAESL
LEAGDMLEFQ DIRDACAEFL EKNLHPTNCL GMLLLSDAHQ CTKLYELSWR MCLSNFQTIR
KNEDFLQLPQ DMVVQLLSSE ELETEDERLV YESAINWISY DLKKRYCYLP ELLQTVRLAL
LPAIYLMENV AMEELITKQR KSKEIVEEAI RCKLKILQND GVVTSLCARP RKTGHALFLL
GGQTFMCDKL YLVDQKAKEI IPKADIPSPR KEFSACAIGC KVYITGGRGS ENGVSKDVWV
YDTLHEEWSK AAPMLVARFG HGSAELKHCL YVVGGHTAAT GCLPASPSVS LKQVEHYDPT
INKWTMVAPL REGVSNAAVV SAKLKLFAFG GTSVSHDKLP KVQCYDQCEN RWTVPATCPQ
PWRYTAAAVL GNQIFIMGGD TEFSACSAYK FNSETYQWTK VGDVTAKRMS CHAVASGNKL
YVVGGYFGIQ RCKTLDCYDP TLDVWNSITT VPYSLIPTAF VSTWKHLPS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	589	Family	BTB-kelch protein	IPR017096	PIRSF037037
17	145	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
22	142	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
36	143	Domain	BTB/POZ domain	IPR000210	PF00651
46	144	Domain	BTB/POZ domain	IPR000210	SM00225
46	114	Domain	BTB/POZ domain	IPR000210	PS50097
149	250	Domain	BTB/Kelch-associated	IPR011705	PF07707
149	251	Domain	BTB/Kelch-associated	IPR011705	SM00875
283	505	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
296	340	Repeat	Kelch repeat type 1	IPR006652	SM00612
307	574	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
329	374	Repeat	Kelch repeat type 1	IPR006652	PF01344
341	388	Repeat	Kelch repeat type 1	IPR006652	SM00612
377	431	Repeat	Kelch repeat type 1	IPR006652	PF01344
389	444	Repeat	Kelch repeat type 1	IPR006652	SM00612
445	492	Repeat	Kelch repeat type 1	IPR006652	SM00612
483	522	Repeat	Kelch repeat type 1	IPR006652	PF01344
493	538	Repeat	Kelch repeat type 1	IPR006652	SM00612
506	586	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
528	570	Repeat	Kelch repeat type 1	IPR006652	PF01344
539	585	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007399	nervous system development	Biological Process	TAS	PMID:9566959
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0010976	positive regulation of neuron projection development	Biological Process	IEA	GO_REF:0000120
GO:0016567	protein ubiquitination	Biological Process	IDA	PMID:15983046
GO:0017148	negative regulation of translation	Biological Process	IDA	PMID:19424503
GO:0051603	proteolysis involved in protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0080090	regulation of primary metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0000785	chromatin	Cellular Component	IEA	GO_REF:0000120
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0016363	nuclear matrix	Cellular Component	IEA	GO_REF:0000120
GO:0043025	neuronal cell body	Cellular Component	IEA	GO_REF:0000120
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:19424503

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