SOCS6

Details:

UniProt Entry: O14544
Gene: SOCS6
Class: Other E3 Components
Family: Receptor
Protein length: 535
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O14544
MKKISLKTLR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKD MASCDINGED
EKGGKNRSKS ESLMGTLKRR LSAKQKSKGK AGTPSGSSAD EDTFSSSSAP IVFKDVRAQR
PIRSTSLRSH HYSPAPWPLR PTNSEETCIK MEVRVKALVH SSSPSPALNG VRKDFHDLQS
ETTCQEQANS LKSSASHNGD LHLHLDEHVP VVIGLMPQDY IQYTVPLDEG MYPLEGSRSY
CLDSSSPMEV SAVPPQVGGR AFPEDESQVD QDLVVAPEIF VDQSVNGLLI GTTGVMLQSP
RAGHDDVPPL SPLLPPMQNN QIQRNFSGLT GTEAHVAESM RCHLNFDPNS APGVARVYDS
VQSSGPMVVT SLTEELKKLA KQGWYWGPIT RWEAEGKLAN VPDGSFLVRD SSDDRYLLSL
SFRSHGKTLH TRIEHSNGRF SFYEQPDVEG HTSIVDLIEH SIRDSENGAF CYSRSRLPGS
ATYPVRLTNP VSRFMQVRSL QYLCRFVIRQ YTRIDLIQKL PLPNKMKDYL QEKHY

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
365	497	Homologous_superfamily	SH2 domain superfamily	IPR036860	G3DSA:3.30.505.10
373	472	Domain	SOCS6, SH2 domain	IPR035865	cd10387
374	494	Homologous_superfamily	SH2 domain superfamily	IPR036860	SSF55550
382	467	Domain	SH2 domain	IPR000980	SM00252
384	460	Domain	SH2 domain	IPR000980	PF00017
384	491	Domain	SH2 domain	IPR000980	PS50001
486	535	Domain	SOCS box domain	IPR001496	PS50225
491	534	Domain	SOCS box domain	IPR001496	SM00253
495	535	Domain	SOCS6, SOCS box domain	IPR037345	cd03740
496	531	Domain	SOCS box domain	IPR001496	PF07525
497	535	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235
497	533	Domain	SOCS box domain	IPR001496	SM00969

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010498	proteasomal protein catabolic process	Biological Process	IMP	PMID:20007709
GO:0050868	negative regulation of T cell activation	Biological Process	IEA	GO_REF:0000107
GO:0006952	defense response	Biological Process	TAS	PMID:9344848
GO:0007259	cell surface receptor signaling pathway via JAK-STAT	Biological Process	TAS	PMID:9344848
GO:0009968	negative regulation of signal transduction	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0040008	regulation of growth	Biological Process	IEA	GO_REF:0000120
GO:0001772	immunological synapse	Cellular Component	IDA	PMID:20007709
GO:0005737	cytoplasm	Cellular Component	TAS	PMID:9344848
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:24728074
GO:0035591	signaling adaptor activity	Molecular Function	IBA	GO_REF:0000033

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