SOCS3

Details:

UniProt Entry: O14543
Gene: SOCS3
Class: Other E3 Components
Family: Receptor
Protein length: 225
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O14543
MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV
LKLVHHYMPP PGAPSFPSPP TEPSSEVPEQ PSAQPLPGSP PRRAYYIYSG GEKIPLVLSR
PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
18	185	Homologous_superfamily	SH2 domain superfamily	IPR036860	G3DSA:3.30.505.10
32	129	Homologous_superfamily	SH2 domain superfamily	IPR036860	SSF55550
35	135	Domain	SOCS3, SH2 domain	IPR035863	cd10384
44	133	Domain	SH2 domain	IPR000980	SM00252
46	127	Domain	SH2 domain	IPR000980	PS50001
46	127	Domain	SH2 domain	IPR000980	PF00017
176	223	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235
177	224	Domain	SOCS box domain	IPR001496	PS50225
180	222	Domain	SOCS box domain	IPR001496	SM00253
184	225	Domain	Suppressor of cytokine signalling 3, SOCS box domain	IPR028414	cd03737
186	221	Domain	SOCS box domain	IPR001496	SM00969

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007165	signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0007259	cell surface receptor signaling pathway via JAK-STAT	Biological Process	IDA	PMID:8272873
GO:0045597	positive regulation of cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0046627	negative regulation of insulin receptor signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0050728	negative regulation of inflammatory response	Biological Process	IEA	GO_REF:0000107
GO:0060670	branching involved in labyrinthine layer morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0060674	placenta blood vessel development	Biological Process	IEA	GO_REF:0000107
GO:0070102	interleukin-6-mediated signaling pathway	Biological Process	IDA	PMID:8272873
GO:0072540	T-helper 17 cell lineage commitment	Biological Process	TAS	PMID:27893700
GO:1990830	cellular response to leukemia inhibitory factor	Biological Process	IEA	GO_REF:0000107
GO:0009968	negative regulation of signal transduction	Biological Process	IEA	GO_REF:0000120
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0043066	negative regulation of apoptotic process	Biological Process	TAS	PMID:9266833
GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	Biological Process	IBA	GO_REF:0000033
GO:0097398	cellular response to interleukin-17	Biological Process	IEA	GO_REF:0000107
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-6785860
GO:0009898	cytoplasmic side of plasma membrane	Cellular Component	IDA	PMID:9727029
GO:0001784	phosphotyrosine residue binding	Molecular Function	IEA	GO_REF:0000107
GO:0004860	protein kinase inhibitor activity	Molecular Function	TAS	PMID:9266833
GO:0005126	cytokine receptor binding	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:19027008
GO:0030292	protein tyrosine kinase inhibitor activity	Molecular Function	IDA	PMID:9727029
GO:0035198	miRNA binding	Molecular Function	IEA	GO_REF:0000107

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