SOCS7

Details:

UniProt Entry: O14512
Gene: SOCS7
Class: Other E3 Components
Family: Receptor
Protein length: 581
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O14512
MVFRNVGRPP EEEDVEAAPE PGPSELLCPR HRCALDPKAL PPGLALERTW GPAAGLEAQL
AALGLGQPAG PGVKTVGGGC CPCPCPPQPP PPQPQPPAAA PQAGEDPTET SDALLVLEGL
ESEAESLETN SCSEEELSSP GRGGGGGGRL LLQPPGPELP PVPFPLQDLV PLGRLSRGEQ
QQQQQQQPPP PPPPPGPLRP LAGPSRKGSF KIRLSRLFRT KSCNGGSGGG DGTGKRPSGE
LAASAASLTD MGGSAGRELD AGRKPKLTRT QSAFSPVSFS PLFTGETVSL VDVDISQRGL
TSPHPPTPPP PPRRSLSLLD DISGTLPTSV LVAPMGSSLQ SFPLPPPPPP HAPDAFPRIA
PIRAAESLHS QPPQHLQCPL YRPDSSSFAA SLRELEKCGW YWGPMNWEDA EMKLKGKPDG
SFLVRDSSDP RYILSLSFRS QGITHHTRME HYRGTFSLWC HPKFEDRCQS VVEFIKRAIM
HSKNGKFLYF LRSRVPGLPP TPVQLLYPVS RFSNVKSLQH LCRFRIRQLV RIDHIPDLPL
PKPLISYIRK FYYYDPQEEV YLSLKEAQLI SKQKQEVEPS T

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
384	563	Homologous_superfamily	SH2 domain superfamily	IPR036860	G3DSA:3.30.505.10
389	489	Domain	SOCS7, SH2 domain	IPR035866	cd10388
390	511	Homologous_superfamily	SH2 domain superfamily	IPR036860	SSF55550
398	484	Domain	SH2 domain	IPR000980	SM00252
400	452	Domain	SH2 domain	IPR000980	PF00017
400	509	Domain	SH2 domain	IPR000980	PS50001
504	554	Domain	SOCS box domain	IPR001496	PS50225
509	552	Domain	SOCS box domain	IPR001496	SM00253
513	561	Domain	SOCS7, SOCS box domain	IPR037346	cd03741
514	548	Domain	SOCS box domain	IPR001496	PF07525
515	554	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235
515	551	Domain	SOCS box domain	IPR001496	SM00969

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0009968	negative regulation of signal transduction	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0021819	layer formation in cerebral cortex	Biological Process	ISS	GO_REF:0000024
GO:0038026	reelin-mediated signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:2001222	regulation of neuron migration	Biological Process	ISS	GO_REF:0000024
GO:0008286	insulin receptor signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0031466	Cul5-RING ubiquitin ligase complex	Cellular Component	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:20598684
GO:0017124	SH3 domain binding	Molecular Function	NAS	PMID:9344857
GO:0035591	signaling adaptor activity	Molecular Function	IBA	GO_REF:0000033
GO:0140031	phosphorylation-dependent protein binding	Molecular Function	ISS	GO_REF:0000024
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	ISS	GO_REF:0000024

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