SOCS2

Details:

UniProt Entry: O14508
Gene: SOCS2
Class: Other E3 Components
Family: Receptor
Protein length: 198
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O14508
MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PQAARLAKAL RELGQTGWYW GSMTVNEAKE
KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD
SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL YLTKPLYTSA PSLQHLCRLT INKCTGAIWG
LPLPTRLKDY LEEYKFQV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
31	158	Homologous_superfamily	SH2 domain superfamily	IPR036860	G3DSA:3.30.505.10
37	132	Homologous_superfamily	SH2 domain superfamily	IPR036860	SSF55550
40	142	Domain	SOCS2, SH2 domain	IPR035862	cd10383
46	135	Domain	SH2 domain	IPR000980	SM00252
48	129	Domain	SH2 domain	IPR000980	PF00017
48	62	Domain	SH2 domain	IPR000980	PR00401
48	156	Domain	SH2 domain	IPR000980	PS50001
67	77	Domain	SH2 domain	IPR000980	PR00401
118	132	Domain	SH2 domain	IPR000980	PR00401
150	197	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235
151	197	Domain	SOCS box domain	IPR001496	PS50225
154	195	Domain	SOCS box domain	IPR001496	SM00253
158	198	Domain	Suppressor of cytokine signalling 2, SOCS box domain	IPR028410	cd03736
160	194	Domain	SOCS box domain	IPR001496	SM00969
161	191	Domain	SOCS box domain	IPR001496	PF07525

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0009968	negative regulation of signal transduction	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0007259	cell surface receptor signaling pathway via JAK-STAT	Biological Process	IEA	GO_REF:0000107
GO:0007595	lactation	Biological Process	IEA	GO_REF:0000107
GO:0038162	erythropoietin-mediated signaling pathway	Biological Process	IDA	PMID:2163696
GO:0040014	regulation of multicellular organism growth	Biological Process	IEA	GO_REF:0000107
GO:0040015	negative regulation of multicellular organism growth	Biological Process	IEA	GO_REF:0000107
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:34518685
GO:0045666	positive regulation of neuron differentiation	Biological Process	IEA	GO_REF:0000107
GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	Biological Process	IEA	GO_REF:0000107
GO:0060396	growth hormone receptor signaling pathway	Biological Process	IDA	PMID:2825030
GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	Biological Process	IDA	PMID:12552091
GO:0060749	mammary gland alveolus development	Biological Process	IEA	GO_REF:0000107
GO:0001558	regulation of cell growth	Biological Process	NAS	PMID:9727029
GO:0009966	regulation of signal transduction	Biological Process	NAS	PMID:9727029
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0032355	response to estradiol	Biological Process	IDA	PMID:12552091
GO:0032870	cellular response to hormone stimulus	Biological Process	IDA	PMID:12552091
GO:0043066	negative regulation of apoptotic process	Biological Process	TAS	PMID:9266833
GO:0060400	negative regulation of growth hormone receptor signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952039
GO:0031466	Cul5-RING ubiquitin ligase complex	Cellular Component	IDA	PMID:21980433
GO:0005126	cytokine receptor binding	Molecular Function	IBA	GO_REF:0000033
GO:0005131	growth hormone receptor binding	Molecular Function	IEA	GO_REF:0000107
GO:0005159	insulin-like growth factor receptor binding	Molecular Function	IPI	PMID:9727029
GO:0005515	protein binding	Molecular Function	IPI	PMID:11781573
GO:0008269	JAK pathway signal transduction adaptor activity	Molecular Function	TAS	PMID:9266833
GO:0140031	phosphorylation-dependent protein binding	Molecular Function	IEA	GO_REF:0000107
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:11781573

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.