TRI38

Details:

UniProt Entry: O00635
Gene: TRIM38
Class: RING
Family: RING5
Protein length: 465
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>O00635
MASTTSTKKM MEEATCSICL SLMTNPVSIN CGHSYCHLCI TDFFKNPSQK QLRQETFCCP
QCRAPFHMDS LRPNKQLGSL IEALKETDQE MSCEEHGEQF HLFCEDEGQL ICWRCERAPQ
HKGHTTALVE DVCQGYKEKL QKAVTKLKQL EDRCTEQKLS TAMRITKWKE KVQIQRQKIR
SDFKNLQCFL HEEEKSYLWR LEKEEQQTLS RLRDYEAGLG LKSNELKSHI LELEEKCQGS
AQKLLQNVND TLSRSWAVKL ETSEAVSLEL HTMCNVSKLY FDVKKMLRSH QVSVTLDPDT
AHHELILSED RRQVTRGYTQ ENQDTSSRRF TAFPCVLGCE GFTSGRRYFE VDVGEGTGWD
LGVCMENVQR GTGMKQEPQS GFWTLRLCKK KGYVALTSPP TSLHLHEQPL LVGIFLDYEA
GVVSFYNGNT GCHIFTFPKA SFSDTLRPYF QVYQYSPLFL PPPGD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	91	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
16	63	Domain	Zinc finger, RING-type	IPR001841	PS50089
16	62	Domain	Zinc finger, RING-type	IPR001841	SM00184
31	40	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
88	129	Domain	B-box-type zinc finger	IPR000315	PS50119
88	129	Domain	B-box-type zinc finger	IPR000315	SM00336
89	126	Domain	B-box-type zinc finger	IPR000315	PF00643
274	465	Domain	B30.2/SPRY domain	IPR001870	PS50188
280	461	Domain	E3 ubiquitin-protein ligase TRIM38, PRY/SPRY domain	IPR035790	cd15815
284	460	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
285	457	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
290	307	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
291	343	Domain	SPRY-associated	IPR006574	SM00589
294	342	Domain	SPRY-associated	IPR006574	PF13765
307	324	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
329	353	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
344	464	Domain	SPRY domain	IPR003877	SM00449
347	453	Domain	SPRY domain	IPR003877	PF00622
359	372	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
403	427	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
434	452	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0032648	regulation of interferon-beta production	Biological Process	IEA	GO_REF:0000107
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0045070	positive regulation of viral genome replication	Biological Process	IEA	GO_REF:0000107
GO:0050687	negative regulation of defense response to virus	Biological Process	IEA	GO_REF:0000107
GO:0070936	protein K48-linked ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0016925	protein sumoylation	Biological Process	IEA	GO_REF:0000041
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0046596	regulation of viral entry into host cell	Biological Process	IBA	GO_REF:0000033
GO:0046598	positive regulation of viral entry into host cell	Biological Process	IDA	PMID:18248090
GO:0048524	positive regulation of viral process	Biological Process	IEA	GO_REF:0000117
GO:1903900	regulation of viral life cycle	Biological Process	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1031716
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0005515	protein binding	Molecular Function	IPI	PMID:23275563
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾


O00635	TRI38	Yes	Yes	No	No	25416956	EBI-10483236	E3-specific

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