PEX12

Details:

UniProt Entry: O00623
Gene: PEX12
Class: RING
Family: RING1
Protein length: 359
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>O00623
MAEHGAHFTA ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPT HYGFLWRWFD
EIFTLLDLLL QQHYLSRTSA SFSENFYGLK RIVMGDTHKS QRLASAGLPK QQLWKSIMFL
VLLPYLKVKL EKLVSSLREE DEYSIHPPSS RWKRFYRAFL AAYPFVNMAW EGWFLVQQLR
YILGKAQHHS PLLRLAGVQL GRLTVQDIQA LEHKPAKASM MQQPARSVSE KINSALKKAV
GGVALSLSTG LSVGVFFLQF LDWWYSSENQ ETIKSLTALP TPPPPVHLDY NSDSPLLPKM
KTVCPLCRKT RVNDTVLATS GYVFCYRCVF HYVRSHQACP ITGYPTEVQH LIKLYSPEN

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	358	Family	Peroxisome assembly protein 12	IPR017375	PIRSF038074
6	357	Family	Peroxisome assembly protein 12	IPR017375	PTHR12888
26	267	Domain	Pex, N-terminal	IPR006845	PF04757
303	358	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007031	peroxisome organization	Biological Process	IEA	GO_REF:0000117
GO:0015031	protein transport	Biological Process	IEA	GO_REF:0000043
GO:0016558	protein import into peroxisome matrix	Biological Process	IEA	GO_REF:0000120
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:24662292
GO:0000425	pexophagy	Biological Process	IDA	PMID:26344566
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:27597759
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	Biological Process	ISS	PMID:35768507
GO:0016562	protein import into peroxisome matrix, receptor recycling	Biological Process	IDA	PMID:16854980
GO:0034614	cellular response to reactive oxygen species	Biological Process	IDA	PMID:26344566
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	ISS	PMID:35768507
GO:0043335	protein unfolding	Biological Process	IDA	PMID:16854980
GO:0044721	protein import into peroxisome matrix, substrate release	Biological Process	IDA	PMID:26344566
GO:0006625	protein targeting to peroxisome	Biological Process	NAS	PMID:12096124
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0005777	peroxisome	Cellular Component	IEA	GO_REF:0000043
GO:0005778	peroxisomal membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-9603775
GO:1990429	peroxisomal importomer complex	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IDA	PMID:24662292
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:10562279
GO:0008320	protein transmembrane transporter activity	Molecular Function	ISS	PMID:35768507
GO:1990757	ubiquitin ligase activator activity	Molecular Function	IDA	PMID:24662292

Enzyme–Substrate Interactions ▾


P50542	PEX5	Yes	Yes	Yes	No	12096124, 10562279	EBI-8489605	Cluster-specific

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.