TRAF5

Details:

UniProt Entry: O00463
Gene: TRAF5
Class: RING
Family: RING1
Protein length: 557
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 7l3l

Protein Sequence ▾

>O00463
MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS VLHNPHQTGC
GHRFCQHCIL SLRELNTVPI CPVDKEVIKS QEVFKDNCCK REVLNLYVYC SNAPGCNAKV
ILGRYQDHLQ QCLFQPVQCS NEKCREPVLR KDLKEHLSAS CQFRKEKCLY CKKDVVVINL
QNHEENLCPE YPVFCPNNCA KIILKTEVDE HLAVCPEAEQ DCPFKHYGCA VTDKRRNLQQ
HEHSALREHM RLVLEKNVQL EEQISDLHKS LEQKESKIQQ LAETIKKLEK EFKQFAQLFG
KNGSFLPNIQ VFASHIDKSA WLEAQVHQLL QMVNQQQNKF DLRPLMEAVD TVKQKITLLE
NNDQRLAVLE EETNKHDTHI NIHKAQLSKN EERFKLLEGT CYNGKLIWKV TDYKMKKREA
VDGHTVSIFS QSFYTSRCGY RLCARAYLNG DGSGRGSHLS LYFVVMRGEF DSLLQWPFRQ
RVTLMLLDQS GKKNIMETFK PDPNSSSFKR PDGEMNIASG CPRFVAHSVL ENAKNAYIKD
DTLFLKVAVD LTDLEDL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
11	557	Family	TNF receptor-associated factor TRAF, metazoa	IPR012227	PIRSF015614
27	131	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
43	85	Domain	TNF receptor-associated factor 5, C3HC3D-type RING-HC finger	IPR027130	cd16642
45	82	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
45	84	Domain	Zinc finger, RING-type	IPR001841	SM00184
45	85	Domain	Zinc finger, RING-type	IPR001841	PS50089
60	69	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
128	181	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
132	187	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
183	239	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
183	241	Domain	Zinc finger, TRAF-type	IPR001293	PF02176
188	248	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
358	551	Homologous_superfamily	TRAF-like	IPR008974	G3DSA:2.60.210.10
403	549	Domain	MATH/TRAF domain	IPR002083	PS50144
408	530	Domain	MATH/TRAF domain	IPR002083	SM00061

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0008284	positive regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0007165	signal transduction	Biological Process	IEA	GO_REF:0000120
GO:0007166	cell surface receptor signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0023019	signal transduction involved in regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0023035	CD40 signaling pathway	Biological Process	IDA	PMID:15708970
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	IMP	PMID:12296995
GO:0042981	regulation of apoptotic process	Biological Process	IEA	GO_REF:0000002
GO:0043122	regulation of canonical NF-kappaB signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0048255	mRNA stabilization	Biological Process	IEA	GO_REF:0000107
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IMP	PMID:15121867
GO:0097400	interleukin-17-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0009898	cytoplasmic side of plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005813	centrosome	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0035631	CD40 receptor complex	Cellular Component	ISS	GO_REF:0000024
GO:0005164	tumor necrosis factor receptor binding	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:15121867
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA	GO_REF:0000117
GO:0031996	thioesterase binding	Molecular Function	IEA	GO_REF:0000117
GO:0035591	signaling adaptor activity	Molecular Function	IBA	GO_REF:0000033
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IDA	PMID:26453305

Enzyme–Substrate Interactions ▾

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