RN103

Details:

UniProt Entry: O00237
Gene: RNF103
Class: RING
Family: RING9
Protein length: 685
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>O00237
MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT ILECRGLGYS
GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN FSGEMHFYEL VEDTKDGIWL
VQVIANDRSP LVGKIHWEKM VKKVSRFGIR TGTFNCSSDP RYCRRRGWVR STLIMSVPQT
STSKGKVMLK EYSGRKIEVE HIFKWITAHA ASRIKTIYNA EHLKEEWNKS DQYWLKIYLF
ANLDQPPAFF SALSIKFTGR VEFIFVNVEN WDNKSYMTDI GIYNMPSYIL RTPEGIYRYG
NHTGEFISLQ AMDSFLRSLQ PEVNDLFVLS LVLVNLMAWM DLFITQGATI KRFVVLISTL
GTYNSLLIIS WLPVLGFLQL PYLDSFYEYS LKLLRYSNTT TLASWVRADW MFYSSHPALF
LSTYLGHGLL IDYFEKKRRR NNNNDEVNAN NLEWLSSLWD WYTSYLFHPI ASFQNFPVES
DWDEDPDLFL ERLAFPDLWL HPLIPTDYIK NLPMWRFKCL GVQSEEEMSE GSQDTENDSE
SENTDTLSSE KEVFEDKQSV LHNSPGTASH CDAEACSCAN KYCQTSPCER KGRSYGSYNT
NEDMEPDWLT WPADMLHCTE CVVCLENFEN GCLLMGLPCG HVFHQNCIVM WLAGGRHCCP
VCRWPSYKKK QPYAQHQPLS NDVPS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	677	Family	E3 ubiquitin-protein ligase RNF103	IPR042494	PTHR15302
612	667	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
620	663	Domain	Zinc finger, RING-type	IPR001841	PF13639
621	663	Domain	Zinc finger, RING-type	IPR001841	PS50089
621	662	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007417	central nervous system development	Biological Process	TAS	PMID:9070305
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0036503	ERAD pathway	Biological Process	IBA	GO_REF:0000033
GO:1904380	endoplasmic reticulum mannose trimming	Biological Process	TAS	Reactome:R-HSA-901032
GO:0005783	endoplasmic reticulum	Cellular Component	IBA	GO_REF:0000033
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0044322	endoplasmic reticulum quality control compartment	Cellular Component	IEA	GO_REF:0000108
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:18675248
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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