NEU1B

Details:

UniProt Entry: A8MQ27
Gene: NEURL1B
Class: RING
Family: RING3
Protein length: 555
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>A8MQ27
MGNTVHRTLP DPSPPARLLA TRPCCGPGPE RRPVLGEAPR FHAQAKGKNV RLDGHSRRAT
RRNSFCNGVT FTQRPIRLYE QVRLRLVAVR PGWSGALRFG FTAHDPSLMS AQDIPKYACP
DLVTRPGYWA KALPENLALR DTVLAYWADR HGRVFYSVND GEPVLFHCGV AVGGPLWALI
DVYGITDEVQ LLESAFADTL TPARLSQARF SACLPPSSHD AANFDNNELE NNQVVAKLGH
LALGRAPGPP PADAAAAAIP CGPRERPRPA SSPALLEADL RFHATRGPDV SLSADRKVAC
APRPDGGRTL VFSERPLRPG ESLFVEVGRP GLAAPGALAF GITSCDPGVL RPNELPADPD
ALLDRKEYWV VARAGPVPSG GDALSFTLRP GGDVLLGING RPRGRLLCVD TTQALWAFFA
VRGGVAGQLR LLGTLQSSPA TTTPSGSLSG SQDDSDSDMT FSVNQSSSAS ESSLVTAPSS
PLSPPVSPVF SPPEPAGIKN GECTVCFDGE VDTVIYTCGH MCLCHSCGLR LKRQARACCP
ICRRPIKDVI KIYRP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
36	159	Domain	Neuralized homology repeat (NHR) domain	IPR006573	SM00588
36	551	Family	Neuralized	IPR037962	PTHR12429
38	194	Domain	Neuralized homology repeat (NHR) domain	IPR006573	PS51065
40	193	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
41	192	Domain	Neuralized homology repeat (NHR) domain	IPR006573	PF07177
277	399	Domain	Neuralized homology repeat (NHR) domain	IPR006573	SM00588
279	433	Domain	Neuralized homology repeat (NHR) domain	IPR006573	PS51065
281	430	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
282	425	Domain	Neuralized homology repeat (NHR) domain	IPR006573	PF07177
497	555	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
503	543	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007219	Notch signaling pathway	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0070086	ubiquitin-dependent endocytosis	Biological Process	ISS	GO_REF:0000024
GO:0005769	early endosome	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0015629	actin cytoskeleton	Cellular Component	IDA	GO_REF:0000052
GO:0005515	protein binding	Molecular Function	IPI	PMID:19723503
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾

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