MARHB

Details:

UniProt Entry: A6NNE9
Gene: MARCHF11
Class: RING
Family: RING2
Protein length: 402
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>A6NNE9
MSFEGGHGGS RCRGAESGDA EPPPQPPPPP PPTPPPGEPA PVPAAPRYLP PLPASPETPE
RAAGPSEPLG EVAPRCRGAD ELPPPPLPLQ PAGQEVAAAG DSGEGPRRLP EAAAAKGGPG
ESEAGAGGER ERRGAGDQPE TRSVCSSRSS SSGGGDQRAG HQHQHHQPIC KICFQGAEQG
ELLNPCRCDG SVRYTHQLCL LKWISERGSW TCELCCYRYH VIAIKMKQPC QWQSISITLV
EKVQMIAVIL GSLFLIASVT WLLWSAFSPY AVWQRKDILF QICYGMYGFM DLVCIGLIVH
EGAAVYRVFK RWRAVNLHWD VLNYDKATDI EESSRGESST SRTLWLPLTA LRNRNLVHPT
QLTSPRFQCG YVLLHLFNRM RPHEDLSEDN SSGEVVMRVT SV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
100	402	Family	E3 ubiquitin-protein ligase MARCHF4/9/11	IPR046356	PTHR46053
154	229	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
162	222	Domain	Zinc finger, RING-CH-type	IPR011016	PS51292
169	216	Domain	Zinc finger, RING-CH-type	IPR011016	SM00744
170	215	Domain	Zinc finger, RING-CH-type	IPR011016	PF12906

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	IEA	GO_REF:0000044
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


P01730	CD4	Yes	Yes	No	No	—	No	Cluster-specific

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