RFPLA

Details:

UniProt Entry: A6NLU0
Gene: RFPL4A
Class: RING
Family: RING5
Protein length: 287
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 2fbe

Protein Sequence ▾

>A6NLU0
MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR FCSVVSQKDD
IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF DVDTANNYLI ISEDLRSFRS
GDLSQNRKEQ AERFDTALCV LGTPRFTSGR HYWEVDVGTS QVWDVGVCKE SVNRQGKIVL
SSEHGFLTVG CREGKVFAAS TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHIYT
FIEIPVCEPW RPFFAHKRGS QDDQSILSIC SVINPSAASA PVSSEGK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	86	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
11	53	Domain	Zinc finger, RING-type	IPR001841	PS50089
54	95	Domain	RDM domain, Ret finger protein-like	IPR022723	PF11002
78	276	Domain	B30.2/SPRY domain	IPR001870	PS50188
88	272	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
88	287	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
93	270	Domain	Ret finger protein-like, SPRY/PRY domain	IPR037960	cd15821
94	111	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
95	147	Domain	SPRY-associated	IPR006574	SM00589
99	146	Domain	SPRY-associated	IPR006574	PF13765
111	128	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
133	157	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
148	270	Domain	SPRY domain	IPR003877	SM00449
150	258	Domain	SPRY domain	IPR003877	PF00622
163	176	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
207	231	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
238	256	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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