TR64C

Details:

UniProt Entry: A6NLI5
Gene: TRIM64C
Class: RING
Family: RING5
Protein length: 450
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>A6NLI5
MDSDTLRVFQ NELICCICVN YFIDPVTTDC VHSFCRPCLC LCSEEGRAPM RCPLCRKISE
KPNFNTNVAL KKLASLARQT RPQNINSSDN ICVLHEETKE LFCEADKRLL CGPCSESPEH
MAHSHSPIGW AAEECRVQKL IKEMDYLWKI NQETQNNLNQ ETSKFCSLVD YVSLRKVIIT
IQYQKMHIFL DEEEQRHLQA LEREAKELFQ QLQDSQVRMT QHLEGMKDMY RELWETYHMP
DVELLQDVGN ISARTDLAQM PKPQPVNPEL TSWCITGVLD MLNNFRVDNA LSTEMTPCYI
SLSEDVRRVI FGDDHRSAPM DPQGVESFAV WCAQAFTSGK HYWEVDVTHS SNWILGVCRD
SRTADTNIVI DSDKTFFSIS SKTSNHYSLS TNSPPLIQYV QRPLGWVGVF LDYDNGSVSF
FDVSKGSLIY GFPPSSFSSP LRPFFCFGCT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	78	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
15	56	Domain	Zinc finger, RING-type	IPR001841	PS50089
30	39	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
87	128	Domain	B-box-type zinc finger	IPR000315	SM00336
87	128	Domain	B-box-type zinc finger	IPR000315	PS50119
269	450	Domain	B30.2/SPRY domain	IPR001870	PS50188
278	450	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
279	449	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
302	319	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
338	450	Domain	SPRY domain	IPR003877	SM00449
340	448	Domain	SPRY domain	IPR003877	PF00622
353	366	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
398	422	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
429	447	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.