TRI75

Details:

UniProt Entry: A6NK02
Gene: TRIM75
Class: RING
Family: RING5
Protein length: 468
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>A6NK02
MAVAAALTGL QAEAKCSICL DYLSDPVTIE CGHNFCRSCI QQSWLDLQEL FPCPVCRHQC
QEGHFRSNTQ LGRMIEIAKL LQSTKSNKRK QEETTLCEKH NQPLSVFCKE DLMVLCPLCT
QPPDHQGHHV RPIEKAAIHY RKRFCSYIQP LKKQLADLQK LISTQSKKPL ELREMVENQR
QELSSEFEHL NQFLDREQQA VLSRLAEEEK DNQQKLSANI TAFSNYSATL KSQLSKVVEL
SELSELELLS QIKIFYESEN ESSPSIFSIH LKRDGCSFPP QYSALQRIIK KFKVEIILDP
ETAHPNLIVS EDKKRVRFTK RKQKVPGFPK RFTVKPVVLG FPYFHSGRHF WEIEVGDKSE
WAIGICKDSL PTKARRPSSA QQECWRIELQ DDGYHAPGAF PTPLLLEVKA RAIGIFLDYE
MGEISFYNMA EKSHICTFTD TFTGPLRPYF YVGPDSQPLR ICTGTVCE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	92	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
16	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
16	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
31	40	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
92	133	Domain	B-box-type zinc finger	IPR000315	SM00336
92	133	Domain	B-box-type zinc finger	IPR000315	PS50119
93	133	Domain	B-box-type zinc finger	IPR000315	PF00643
276	468	Domain	B30.2/SPRY domain	IPR001870	PS50188
276	462	Domain	TRIM75, PRY/SPRY domain	IPR035785	cd15829
286	467	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
287	463	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
292	309	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
293	345	Domain	SPRY-associated	IPR006574	SM00589
296	342	Domain	SPRY-associated	IPR006574	PF13765
309	326	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
331	355	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
346	465	Domain	SPRY domain	IPR003877	SM00449
348	456	Domain	SPRY domain	IPR003877	PF00622
361	374	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
404	428	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
434	452	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007144	female meiosis I	Biological Process	ISS	GO_REF:0000024
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005615	extracellular space	Cellular Component	HDA	PMID:22664934
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000117
GO:0005819	spindle	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

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