TR49B

Details:

UniProt Entry: A6NDI0
Gene: TRIM49B
Class: RING
Family: RING5
Protein length: 452
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>A6NDI0
MNSGILQVFQ RELICPICMN YFIDPVTIDC GHSFCRPCFY LNWKDSPFLV QCSECTKSTG
QINLKTNIHF KKMASLARKV SLWLFLSSEE QMCGTHRETK KMFCEVDRSL LCLLCSSSQE
HRDHRHCPIE SAAEEHQEKL LQKMQSLWEK ACENHRNLNV ETTRTRCWKD YVNLRLEAIR
AEYQKMPAFH HEEEKHNLEM LKKKGKDIFH RLHLSKAKMA HRREILRGMY EELNEMCHKP
DVELLQAFGD ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANSDI
FLCEILRSMC IGCDHQDVPY FTATPRSFLA WGAQTFTSGK YYWEVHVGDS WNWAFGVCNM
YWKEKNQNEK IDGEDGLFLL GCVKNDIQRS LFTTSPLLLQ YIPRPTSRVG LFLDCEAKTV
SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI HF

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	84	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
15	55	Domain	Zinc finger, RING-type	IPR001841	SM00184
15	56	Domain	Zinc finger, RING-type	IPR001841	PS50089
88	129	Domain	B-box-type zinc finger	IPR000315	PS50119
88	129	Domain	B-box-type zinc finger	IPR000315	SM00336
89	129	Domain	B-box-type zinc finger	IPR000315	PF00643
269	452	Domain	B30.2/SPRY domain	IPR001870	PS50188
279	450	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
279	451	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
285	302	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
323	347	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
338	452	Domain	SPRY domain	IPR003877	SM00449
340	449	Domain	SPRY domain	IPR003877	PF00622
353	366	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
400	424	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
431	449	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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