>sp|Q5TC82|RC3H1_HUMAN/1-1133 Roquin-1 OS=Homo sapiens OX=9606 GN=RC3H1 PE=1 SV=1 MPVQAPQWTDF-LSC-----------------------PI-C------TQ---T------F----------- ------------------------------------------------------------------------ -----------------------------------------------D--ETIRKP--I------------- ---SL-----------GCGH--TVCKMCL------------------NKLHRKACPFDQTTINTDIELLPVN SALLQLVGAQVPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLS-------SARG----VGLNSTTQSV LSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGER-------------------T---V-----TE----- -----------LILQHQNPQ---QL-------------------------S-SN-------L------WAAV RA-------------RG----------------------------------------CQF------------ --L--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------GPAMQEEALKL-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------V--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------LLAL--EDGSA----------LS- ------------------------------------------------------------------------ --------------R-----------------K--------------------------------------- ----------------------------------------------------------------------VL -------------------------------------VLFVVQR---------------------------- ---------------LEPRFPQASKTSIGHVVQLLYRAS------------------------CFKVTKRD- ----------------------------------------------------------ED------------ ------------------------------------------------------------------------ ------------------------------------------------SSLMQL-KEEFR------------ ------------------------------------------------------------------------ ------------------------------------------------TYEALRREH-------------DS Q--IV------------------------------------------------------------QIAMEAG LRIAPD------------------------------------------------------------------ -------------------------------------------------------------QWSSLLY--GD QSHKSHMQSIIDKLQTPASFAQSVQELTIALQ----RTG--------DPA-------------NLNRLRPHL ELLANIDPSPDAPPPTWEQLENGLVAVRTVVH---------------------------------------- ------------------------------------------------------------------------ --------------------------------------GLVDYIQNHSKKGADQQQPP-------------- -------------------------QHSKY-----------------KT----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------YMCRDMKQRGGC P----------------------------------------------------RGASCTFAHSQEELEKFRK MNK--------------------------------------------------------------------- --------------------------------------------------------------------RLV- --PRRPLSAS-------------------------------------------------------------- -----------------------------------------------------------------LG----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------QL-------------------------N--------------------------------- ---------------------------------EVGL----------------------------------- --------------------------------------------------------------PSAAILPDEG AVDLPSRKPPALPNG------------------------------------IV----S-----------TGN ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------T---VTQ--------------------------------- -------------LIPRGTDP-------------------------------------SY---DSSLK---- ------------------------------------------------------------------------ -------------------PGK-------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------IDHLSSSAPGSPPDLL ESVPKSISALPVNPHSIPPRGPADLPPMPVTKPLQMVPRGSQLYPAQQTDVYYQDPRGAAPPFEPAPYQQGM YYTPPPQCVSRFVRPPPSAPEPAPPYLDHY-----------PPYLQERVVNSQYGT---------------- ---------Q----------------------------------P--------------------------- ------------------------------------------------------------QQ---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------YPP------------------------------------------------ ---------------------------------I-------------------------------------- ------------------------------------------------------------------------ --------------------------------------------YPSHYDGRRVY-P--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------APSYT----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------REEIFRE----------------------------------- --------------------------------------------------------------SPIPIEIPPA AVPSYVPESRERYQQIESYYPVAPHPTQIRPSYLREPPYSRLPPPP-------------------------- --------------------------------------------------------------QPHPSLDELH --R--------------------------------------------------------------------- ------------------RRKEIMAQLEE------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------RK--V I----------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------SPPPFAP-SPTLP-P---------- ----------------------------------------------TFHPE--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------EFLDED-L---------------- -------K---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------VAG-KYKGNDYSQYSPWSCDT IGSYIGTKDAKPKDVVAAGSVEMMNVESKGM--RDQRLDLQRRAAETSDDDLIPFGDRPTVSRFGAISRTSK TIYQGAGPMQAMAPQGAPTKSINISDYSPYGT--HGGWG-----------------------------ASPY SPH------------QNIPSQGHFS-----------------ER------ERISMSEVA--SHG-----KPL PSAEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREANTLAGQ------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------------S QP-----PPPPPPKWPGMISSEQLSLEL-----HQVE----------------------------------- ----------------REIGKRTRELS---MEN--------------------------------------- -Q----CS----LDMK------------SK----------LN-------------------TSKQAE----- ------N-----GQ-------------------------------------------PEPQN---------K ---------------VPA-E--DLTLTFS-DVPNGS------------ALTQ-E-NISLLSNKTSSLNLSED PEGGGD------------------NNDSQ-RSGVTPSSAP >sp|Q86YT6|MIB1_HUMAN/1-1006 E3 ubiquitin-protein ligase MIB1 OS=Homo sapiens OX=9606 GN=MIB1 PE=1 SV=1 MSNSRNNRVMV-EGVGARVVRGPDWKWGKQDGGEGHVGTV-RS----F------------ESPE-------- -----E------------------------------------------------------------------ ------VVVVWDNGTAANYRCS--GA--------------------YD--LRILDS--A------------- ---PT-----------GIKHDGTMCDTCR-------------------------QQP--------------- ---------------------------------------------II-------GIR--------------- -----------------------------------W-------------------K---CAECTNYD----- -----------LCTVCYHGD---KH----HL------------RHR-FYRI-TT-------PGSERVLLESR RKSKKITARGIFAGARV----------------------------------------VRG------------ --VD---W---------------------------------------------------------------- -----------------------Q-------------------------WED-----QDGGN---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------GR RGKVTE------------------------------------------------------------------ --------------------------------------------------IQDW------------------ ---SASSP--------------------HSAAY---V----------------------------------- --------------L------------WD-NGA------------------------KNLYRVGFEG----- ------------------MS------------------D--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------LKCVQDAKGGS----------FY- ------------------------------------------------------------------------ --------------R------------------DHCP----------------------------------- -----------------------------------------------------VLGEQ-----N--GNRNPG -------------------------------------GLQIGDLVNIDLDL--------------------- ----------------------------------------------------------------------EI VQ--------------SLQHGHGGWTDGMFET---------------------------L------------ -------------------------------------------------------------T---------- ------------------------------TT---------------------------------------- ------------------------------------------------------------------------ -------------------------------GTVCGID------------------E--------------- ------------------------------------------------------------------------ -----D----------HDIVV--------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------QYPSGNRWTF--------------------NPA- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------V----------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------LTKAN IVRSGDAAQGAEGGTSQFQVGDL-------------------------------------------V----- ------------------------------------------------------------QVCYDLERIKLL QRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSK------VASAGSAISNAS------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ GERLSQLLKKL------------------------------------------------------------- ------------------------------------------FET------------------QESG----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------DL-------------------------NEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGH TAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVH----------------------------------- -----------------------------------------------HAAFGDEGAVIEVLHRGSADLNARN KRRQTPLHIAV-NKG--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------HLQVVKT--------------------------------- -------------LLDFGCHP-------------------------------------SL------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------QD------------ ----SE------------------------------------------------------------------ -------------------------------------------------------------G---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------DT------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------PLHDAIS --K--------------------------------------------------------------------- ------------------KRDDILAVLLE------------------------------------------- --------------------------------A--------GADVTIT------NNNGFNALHHAALRGNPS AMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVH----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------QGNANLDIQNVNQQTALHLA---------------------------------------- ------------------VERQHT-----------------QI----------------------------- ------------------------------------VRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------L------------------------------------ -------------QDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPL DLC--------------------------PDPNLCKALA-KCHKEKVSGQVGSRSPSMISN----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------DSE TLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEE--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------CVVCSDKK---------------- -------AAV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------LF----------------------QPC--------- ------------------------------------------------------------------------ ---------------------------------GH---------------MC-------------------- ---------------------ACE---------N---CA--------------------------------- ------------------------------------------------------------------------ -------------------------NLMK---------KCV------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------QCRA VVERRVP------------------------------FIM-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------C--- ------------------------------------------------------------------------ -------------------------------------------CGGK------------------------- ------------------------------------------------------------------------ ---------------------------SSED-------ATDDISS--------------------------- ---------GN--I---------------------------------------------------------- -------------------------------------PVLQKDKDNTNVNADVQKLQQQLQD---------- -----------------------------IKEQTMCPVCL------------------------DR-LK--- NM----IF----LCGH-------------------------G-------------------T--CQLC---- ----GDR-----MS-------------------------------------------ECP-I---------C ---------------R---K--AIERR--------------------------------------------- ---------IL--------L-----Y-------------- >sp|Q96AX9|MIB2_HUMAN/1-955 E3 ubiquitin-protein ligase MIB2 OS=Homo sapiens OX=9606 GN=MIB2 PE=1 SV=4 MDPDPQAGVQV-G---MRVVRGVDWKWGQQDGGEGGVGTV-VE----LGRHGSP------STPDR------- -----T------------------------------------------------------------------ ------VVVQWDQGTRTNYRAGYQGA--------------------HD--LLLYDN--A------------- ---QI-----------GVRHPNIICDCCK-------------------------KHG--------------- ---------------------------------------------LR-------GMR--------------- -----------------------------------W-------------------K---CRVCLDYD----- -----------LCTQCYMHN---KH----EL------------AHA-FDRY-ET-------AHSRPVTLSPR QGLPRIPLRGIFQGAKV----------------------------------------VRG------------ --PD---W---------------------------------------------------------------- -----------------------E-------------------------WGS-----QDGGE---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------GK PGRVVD------------------------------------------------------------------ --------------------------------------------------IRGW------------------ ---DVETG--------------------RSVAS---V----------------------------------- --------------T------------WA-DGT------------------------TNVYRVGHKG----- ------------------KV------------------D--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------LKCVGEAAGGF----------YY- ------------------------------------------------------------------------ --------------K------------------DHLP----------------------------------- -----------------------------------------------------RLGKPAELQRR--VSADSQ -------------------------------------PFQHGDKVKCLLDT--------------------- ----------------------------------------------------------------------DV LR--------------EMQEGHGGWNPRMAEF---------------------------I------------ -------------------------------------------------------------G---------- ------------------------------QT---------------------------------------- ------------------------------------------------------------------------ -------------------------------GTVHRIT------------------D--------------- ------------------------------------------------------------------------ -----R----------GDVRV--------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------QFNHETRWTF--------------------HPG- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------A----------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------LTKHH ----------------SFWVGDV-------------------------------------------V----- ------------------------------------------------------------RVIGDLDTVKRL QAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERAREN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ KSSLSVALDKL------------------------------------------------------------- ------------------------------------------RAQ------------------KSDP----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------EH-------------------------PGRLVVEVALGNAARALDLLRRRPEQVDTKNQGR TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALH----------------------------------- -----------------------------------------------YAALGNQPEATRVLLSAGCRADAIN STQSTALHVAV-QRG--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------FLEVVRA--------------------------------- -------------LCERGCDV-------------------------------------NL------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------PD------------ ----AH------------------------------------------------------------------ -------------------------------------------------------------S---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------DT------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------PLHSAIS AGT--------------------------------------------------------------------- ------------------GASGIVEVLTEV------------------------------------------ --------------------------------P--------NIDVTAT------NSQGFTLLHHASLKGHAL AVRKILAR--ARQLVDAKKEDGFTALHLAALNNHREVAQILIR----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------EGRCDVNVRNRKLQSPLHLA---------------------------------------- ------------------VQQAHV-----------------GL----------------------------- ------------------------------------VPLLVDAGCSVNAEDEEGDTALHVALQRHQL----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------L------------------------------------ -------------PLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPL DLA---------------------------------------------------------AEGRVLKALQGC AQRFRERQAGGGA--APGPR---------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------QTLGTPNTV-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------TNLHVGAAP-- ---------------------------------------------GPEAAE--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------CLVCSELA---------------- -------LLV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------LF----------------------SPC--------- ------------------------------------------------------------------------ ---------------------------------QH---------------RT-------------------- ---------------------VCE---------E---CA--------------------------------- ------------------------------------------------------------------------ -------------------------RRMK---------KCI------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------RCQV VVSKKLR------------------------------PDG-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------S--- ------------------------------------------------------------------------ -------------------------------------------EVASAAPAPGPPRQLVEELQS-----RY- ------------------------------------------------------------------------ ---------------RQ-MEE-RITCPI-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------CI------------------------DS-HI--- RL----VF----QCGH-------------------------G-------------------A--CAPC---- ----GSA-----LS-------------------------------------------ACP-I---------C ---------------R---Q--PIRDR--------------------------------------------- ---------IQ--------I----FV-------------- >sp|Q96PU4|UHRF2_HUMAN/1-802 E3 ubiquitin-protein ligase UHRF2 OS=Homo sapiens OX=9606 GN=UHRF2 PE=1 SV=1 MWIQVRTIDGS-KTC-----------------------TI-------EDV---------------SRKATI- ----EELRERVWA-LFDVRPEC---QRL-----------F----------YRGK---------QLENG---- ---YTLFDYD-------------------------------------------------------------- ------------------------------------------------------------VGL--------- ------------------------------------------------------------------------ -----------------------------------------------------------------ND----- -----------IIQLLVRP----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------DPDHLPGTSTQIEA KPCSNSPP--------------------KVKKA---PRVGPSNQPSTSARA--------------------- -------------RL-------------I-DPG------------------------FGIYKVNEL------ -------------------V------------------D--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------AR---DVGLGA----------WF- ------------------------------------------------------------------------ --------------E-----------------A-HIH----------------------------------- -----------------------------------------------------SVTRASDGQS--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------RGKTPLKNGSS CKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPR---------- ------------------------------ARTILKWNELNVGD----VVMVNYNVESPG------------ ----------------------------------------------------QR---GFWFDAEITTLKTIS RTKKELRVKIFL------------------------------------------------------------ ------------------------------------------------------------------------ -GGSEGTLNDCKI----------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------ISVDEIF ------------------------------------------------------------------------ ------------KIE--------------------------------------------------------- --------------------------------RPGAHPLSFADGKFLRR------ND--------------- --------------------------------PECDLCG--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------GDP E----------------------------------------------------K------------------ ---KC------------------------------------------------------------------- ------------------------------------------------------------------------ ------HSCSC------------------------------------------------------------- ------------------------------------------RVC------------------GGK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------HE--------PNM-QLL---CDE--CNV-------------------------------- ----------------------------------AYH----------------------------------- --------------------------------------------------------------IY-------- ------------CLN------------------------------------P----P------------LDK ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------V---PE---------------------------------- -----------------E-------------------------------------------EYWYCPS---- ------------------------------------------------------------------------ -------------------CKTDSSEVVK-AG--ERLKM------------SKKKAKMPSASTESRRDWGRG MACVG----RTRECT--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------IVPS------------ ----NHYGPI----------------------------------P--------------------------- ------------------------------------------------------------GI---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------PVG------------------------------------------------ ---------------------------------S-------------------------------------- ------------------------------------------------------------------------ --------------------------------------------T---------W-RFRVQVSEAG------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------VH----------------------R----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------PHV--------------------------------------------------GGIHGRSN-DGA YSLVLAGGFADEVDRGDEFT--YTGSGGKNLAGN--------KRIGAPSADQTLTNMNRALALNC------- --D--------------------------------------------------------------------- ----------------------A------------PL----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------DDKIG------------------------------------------ ----------------AESRN-WRA-GKPVRV----------IRSFKGRKISKYAPEEGNRYDGIYKVVKYW PEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRL----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------CLRL----------------------------------QYPAG YPS-------DKEGKKPKGQ-------SKKQ--PSGTTK----------R---------------------- -----PISDDDCPSASKVYKA--------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------SDSA------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------EAIEAFQLTPQQQHLI--------------REDCQ------------------ ------------------------------------------------------------------------ ---------------------------------------------------NQKL----------------- -------WDE-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------VL----------------------SHL--------- ------------------------------------------------------------------------ ---------------------------------VEGP-----------NFL--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------KKLE------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------QSFMC---V---------------------------------------- -----------------------------------------------------CCQE-LVYQ---------- -------------------------------------------------P-------VTTECFH-------- -----------------------------------------N-VCKDCLQRSFKA----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------QVF-------------------------------------------SCP-A---------C ---------------R-H----DLGQNY------IM------------------------------------ -----IPN-EI------LQTLLDLFFPGYSKGR------- >sp|O95155|UBE4B_HUMAN/1-1302 Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1 MEELSADEIR--RRR---LARL--------AGGQ-TSQPT-------TPLTS-PQRENPPGPPIAASA--PG P-------------------SQSLGL-N-----------V----------H-------------NMTPATSP IGASGVAHRSQSS---EGVSS---LSSSPSNSLETQSQS-------LS--RSQSMD--I------------- ---DG-----------VSCE------KSMSQVDVDSGIENMEVDENDR-------R---------------- ------------------------------------------------------------------------ ----------------------------EKRSLSDK-------------------E---------------- ------------------------P----SSGPEVSEEQALQLVCK-IFRV-SWKDRDRDVI------FLSS LS-------------AQ----------------------------------------FKQ------------ ---N-------------------------------------------------------------------- ----------------------PK-------------------------EVF-----SD------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------FKDLI---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------G- ------------------------------------------------------------------------ --------------QILMEVLMMSTQTRDENPF--------------------------------------- ----------------------------------------------------------------------AS -------------------------------------LTATSQP---------------------------- ---------------IAAAARS----PDRNL----------------------------------------- --------------------------------------------------------------L--------- -----------------------------------------------------LN----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------T----------------------------------- --------------------------------------------------------------GS-------- ------------NPGTSP--------------------------------------MFCSVASFGASSLSS- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------LYESSPAPTPSFWSSVPVMGPSLASPSRAASQLA VPSTPLSPHSAASGTAAGSQPSSPRYRPYTVTHPWASSGVSILSSSPSPPALASSPQAVPASSSRQRP---- ------------------------------------------------------------------------ -------------------SSTG------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------PPL----------------------------------P--------------------------- ------------------------------------------------------------PASPSATSRRPS SLRISPSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQC ISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSL DSDYFKYPLMALGELCETKFGKTH------------------------------------------------ ---------------------------------P-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -VCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQHY LELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLE TVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRY IRRLRAIRELNRTVEDLKNNESQWKDSPLATRHREML----------------------------------- --------------------------------------------------------------KRCKTQLK-- ---------------------------------------------KLVRCKACADAGLLDESFLRRCLNFYG L----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------LIQLLLRILDPAYPDITL------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------PLNSDVPKVFAALPEFYVED----VAEFLFFIVQYSPQAL--YEPCTQDIVMFLV VMLCNQNYIRNPYLVAKLVE----------VMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVE HTGATSEFYDKFTIRYHISTIFKSLWQNIA------------------------------------------ ------------------------HHGTFMEEFNSGKQFVRYINMLINDTTF-------------------- ------------------------------------LLD-ES--------LESLKRIH----EVQEEMKNKE QWDQ---------------LPRDQQ------Q-----ARQSQL-AQDERVSRSYLAL--------------- ------ATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKC---------------------- ------------------------------------------------------------------------ -------------------------------RDLKVENPEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADD QRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDE--------------- ---------------------------------------------------------FRDPLMD-------- ------------------------------T----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------L-----------MTDPVRL--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------PS---- ----GT-----IMDR----------SII----LRHLLNSP-----------------TDP-F---------N RQTLTESMLEPVPELK-E-Q--IQ-A-W------MR------------------------------------ -------E-KQ-------------------NSDH------ >sp|Q9H992|MARH7_HUMAN/1-704 E3 ubiquitin-protein ligase MARCHF7 OS=Homo sapiens OX=9606 GN=MARCHF7 PE=1 SV=1 MESKPSRIPRR-I-------SVQ---------------PS-S------SLSA-RMMSGSRGS---------- ------------------------------------------------------------------------ ----SLNDTYHSRD---------------------------------------------------------- -----------------------SSF---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------RLDSEY----QS--------------TSASAS-AS-------P------FQSA WY-------------SE----------------------------------------SEI------------ --TQGAR--------------------------------------------------SRSQNQQRDHDSKRP KL---------------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------SCTN------------------- -------------------------------------------------CT--------------------- -----------------------TS---------------------------AGRNV--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------G------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------NGLNTLSDSSWR------ ------------HSQVPRSSS----MVLG-------SFG--------------------TDLMRERRDLER- ----------------------------------------------------------RT------------ -------------------------------------------------------------DSSISNLMDYS HRSGDFTTSSYVQD---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------RVPSY-------------------------------------- ---------SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------TQPGFSYSSSRDEAPIISNSERVVSSQRPFQESSD---- ------------------------------------------------------NEGRRTTRRLLSRIASSM SSTFFSRRSSQDSLNTR------------SLNS---EN---------------------------------- -----------------S---------------------------------------------YVSP----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------RILTASQSRSNVPS--------------- ------------------------------------------------------------------------ -----------------ASEVPDN----------------------------------RA------------ ----SEASQG----------------------------------F--------------------------- ------------------------------------------------------------RF---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------LRR------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------RWGLSSLSHNHSSESDSENF---NQESEGR NTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSRSHIFRRESNEVVHLEAQNDP------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------LG------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------AAANR-PQ-----------------AS----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -AASSSAT--------TGGSTSDSAQGGRNTGISGILPGSLFRFAVPP------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------ALGSNLTDNVMITVD IIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL--------------LEDSE------------------ ----EEE--------------G-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------DLC---R---------------------------------------- -----------------------------------------------------ICQM-AAAS-S-S------ ----------------------------------------N--------L-------LIEPCKC-------- ------------------------------TGS----LQ--Y-VHQDCMKKWLQAKINSGSSL--------- --------------------EAVTTC------------EL--C----------------------------- ------------------------------------------------------------------------ -------------------------------KEKLEL----------------------------------- -NL------------EDFDIHELHRAHANEQAEYEFISSGLYLV---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------VLLH------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------LCEQ SFSDMMG-----NTNEPSTRVRFINLARTLQAH------MEDLETSEDDSEEDGDHN--------------- -----------------R-T--F--------------------------------DI--------------- ----------A----------------------------- >sp|O60337|MARH6_HUMAN/1-910 E3 ubiquitin-protein ligase MARCHF6 OS=Homo sapiens OX=9606 GN=MARCHF6 PE=1 SV=2 MDTAEEDIC---------------------------------------RV---------------C------ ------------R-S----EGT-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------PE-------------K---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------PL-----YHPC----------- --------VC------TGSIKFIH------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------QECLVQ-WLKH---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------SRKEYCELCKHRF-------- ---AFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLT LPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAP--I------------------------ ------------------------------------------------------------------------ -------------WLE-----------------H-------------------------------------- -----------------------------------------------------------------------A APPFNA------------------------------------------------------------------ ------------------------------------------------------------------------ -A---------------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------GH-------------- ---------------------------------------HQNEAPAGGNGAENVAADQPANPPAENAVVGEN PDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMN------------------WNALEWDRA------- -------------------AEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLV---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------GLGFEEH-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------VQASHFEGLITTIVGYILLAITLIICHGLATLVKFHRS R----------------------------------------------------R------------------ ---LLGVCYIVVKV---------------------------------------------------------- --------------------------------------------------------------------SLL- --VVVEIGVFP------------------------------------------------------------- ------------------------------------------LIC------------------GW------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------WLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLR--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------PGV--------------- -----L-WFL-------------------------------------------------------------R NLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYN-------------- ------------------------------------VMLYSDAPVSELSLELLLLQVVLPALLEQGHTR--- --------------------------------------------------------QWLKGLVRAWTVTAGY LLDLHSYLLGDQEENENSANQ--------------------------------------------------- ---------------QVNNNQHARNNNAIPV--VGEGLH-AA------------------------------ HQA-ILQQ--GGPVGFQPYRRPLNFPLRIFLLIVF---MCITLLIASLICLTLPVFAGRWLMSFW------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------TGTAKIHE------------------LYTAA----CGLYVCWLT---------------------- -------------IRAVTVMVAWMPQGRRV------------------------------------------ ------------------------------IF---------QKVK--------------------------- ------------------------EWS-----------------------LMIMKTLIVAVLLAGV------ -------------VPLLLGLLFELVIVAPLRVPL---DQT-P--------L--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------F-------- -----------------------------------------Y-PWQDWALGVLHA----------------- ----------------------KIIA------------AIT------------------------------- ------------------------------------------------------------------------ -------------------------------LM--------------------------------------- ------------------------------------------------------------GPQW-----WL- ------------------------------------------------------------------------ ---------------KT-VIEQVYA-NGIRN-------IDLHYIV--------------------------- ---------RKLAA---------------------------------------------------------- -------------------------------------PVIS--------------------VLLLSLCVPYV IASGVVPLLGVTAEM-QNLVHR--------RIY--PFLLMVVVLMAILSFQVRQFKRLYEHIKND------- ------KY----LVGQ------------RL--------VNYERKSGKQGSSPPPPQ--S------------- ------------------------------------------------------------------------ --------------------------------------SQE------------------------------- ---------------------------------------- >sp|Q8WU17|RN139_HUMAN/1-664 E3 ubiquitin-protein ligase RNF139 OS=Homo sapiens OX=9606 GN=RNF139 PE=1 SV=1 MAAVGPPQQQV-------------------------------------RM---------------A------ ---------H-QQ-V----WAA-----------------------------------L-------------- -------------E---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------VALRV-PC-------------LY-II DA-------------IF----------------------------------------NSY------------ --PD---S----------------------------------SQSRFCIVLQIFLRLFG------------- -------------------------------------------------VFA-----SSIV----------- --------LI------LSQ---RSLFKF-------------------------------------------- ----------------------------------------------YTY-SS-------------------- --------------------------------------------------AFLLA----------------- -----------------------------ATSVL---------VNYYASLHI---DF--------------- ------YGAYNTSAFGIELLP---------------RKGPSLWMALIVLQLTFGIGYVTLLQIHSIYSQLII LDLLV------------------------------------------------------------------- --P-----------------------------------------------VIGLITE-LPLHIRETLLFTSS LI---------------------------------------------------------------------- -----------------------------------------------------------------LT----- ------------------LN------------------TVFVLAVKLKWFYYSTRYV-YLLVRH-------- ---MYR------------------------------------------------------------------ -----------------------------------IYGLQLLMED--T------------------------ ------------------------------------------------------------------------ -------------WKR-----------------I-------------------------------------- -----------------------------------------------------------------------R FPDILR------------------------------------------------------------------ ------------------------------------------------------------------------ -V---------------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------FW-------------- ---------------------------------------LTRV----------------------------- ---------------TAQATVLMYILRMANETDSFFIS------------------WD-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------DFWDLICNLIISGCDST--- --------------------------------------------------------LTVLGMS--------- ----------AVISSVAHYLG--------------------------------------------------- ---------------LGILAFIGSTEEDDRR--LGFVAP-VL------------------------------ FFI-LALQ--TGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSAS------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------HVSSFRRH------------------FPVLF----VSACLFILPVLLSYVL--WHHYALNTWLFAV TAFCVE--LCLKVIVSLTV----------YTLFMIDG----------------------------------- --------------------------YYNVLW---------EKLD--------------------------- ------------------------DYV-----------------------YYVRSTGSIIEFIFGV------ -------------V-----------MFGNGAYTM---MFE-S--------GSK------------------- ------------------------------------------------------------------------ --------------------------IRAFMMCLHAYFNIYLQAKNGW------------------------ -----------------------------------------------KTFMN-------------------- -----RRTAVKKINSLPEIKGSRLQEINDVCA---------------------------------------- -----------------------------------------------------ICYHEFTTS---------- --------------------------------------------------------ARITPCNH-------- -----------------------------------------Y-FHALCLRKWLYI----------------- ----------------------QDTC------------PMC------------------------------- ------------------------------------------------------------------------ -------------------------------HQ--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------KVYIE------- ------DD----IK-------------------------DNSNVSNNNGFIPP-NE--T-PE---EAV---- --R--------------------------------------------------------------------- ----------------------EAAAES------DRELNEDDSTDCDDDVQRERNGV--------------- -----IQHTGA--AAEEFNDDTD----------------- >sp|Q9P253|VPS18_HUMAN/1-973 Vacuolar protein sorting-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2 MASILDEYENS-LSR-----------------------S--------------------------------- ---------------AVLQPGC---PSV-------------------------------------------- ----GIPHSGYVNA----------QLE---------KEVP-IFTK-QRIDFTPSE----------------- ------------------------------------------------------------------------ ---------------------------------------RITSLVV-------------------------- -----------------------------------SSNQLCMSLGKDTLLRIDLGK---ANEPNH-VELGRK DDAKVHKMFLDHTGSHLLIA---LSSTEVLY------------VNRNGQKV-RP-------L------ARWK ---------------GQLVESVGWNKALGTESSTGPILVGTAQGHIFEAELSASEGGLFG------------ --PA-------------------------------------------------------------------- ----------------------PD-L------------------------YF-----RPLYV---------- ---------L------NEE---GGPAPV------------CSLEAERGPDGRSFVIATTRQRLFQFIG---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------RAAEGAEAQGFSGLFAAY- ------------------------------------------------------------------------ --------------T-----------------D-HPPPFREFPSNLGYSELAFYTPKLRSAPRAFAWMMGDG VLYGALDCGRPDSLLSEERVWEYPEGVGPGASPPLAIVLTQFHFLLLLADRVEA------------------ ------------------------------------------------------------------------ --------------VCTLTGQV----VLRDH--FLEKFGPLKHMVKDSSTGQLWAYTERA----VFRYHV-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------VSGTKFEEDHLSHYSPWSCGT IGSCINAIDSEPKDVIANSNAVLMDLDSGDVKRRVHLFETQRRT--KEEDPIIPFSDGPIISKWGAISRSSR TGYHTTDPVQATASQGSATKPISVSDYVPYVNAVDSRWS--------------------------------- SYG------------NEATSSAHYV-----------------ER------DRFIVTDLS--GHR-----KH- -SSTGDLLSLELQQ---------------AKSNSLLLQREANALAMQQKWNSLDEGRHLTLNLLSKEIELRN GELQSDYTEDATDTKPDRDIELELSALDTDE-------P--------------------------------- ------------------------------------DG-QS--EPIEEILDIQLGISSQNDQLLNGMAVENG HPVQQHQK--EPPK--------------------QKK----------------------------------- ----------------QSLGEDHVILEEQKTIL--------------------------------------- -P----VT----SCFS------------QP----------LP-------------------V--SIS----- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------SIDDGELLHGILKIIISW KKEHED-IFL-------------------------------------------------------------F SCNLSEASPEVLGVNIEIIRFLSL------------------------------------------------ -------------------------------------------------------------FLKYCSSPLAE SEWDFIMCSMLAWLETTSENQALYSIPLVQLFACVSCDLACDLSAFFDSTTLDTIGNLPVNLISE------- 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GN=RNF145 PE=2 SV=2 MAAKEKLEAVL-------------------------------------NV---------------A------ -----------LR-V----PSI----------------------------------MLLDVLYRWDVS---- ------SFFQQIQR---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------SSLSN-NP-------------LFQYK -Y-------------LA----------------------------------------LNM------------ --HY---V--------------------------------------------------G------------- -------------------------------------------------YIL-----SVVL----------- --------LT------LPR---QHLVQL-------------------------------------------- ----------------------------------------------YLYFLT-------------------- --------------------------------------------------ALLLY----------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------PAMN--RGMTEG-VT------------------------------ LLI-LAVQ--TGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGAS------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------RDKSLWKH------------------FRAVS----LCLFLLVFPAYMAYMI--CQFFHMDFWLLII ISSSIL--TSLQVLGTLFIY----------VLFMVEE----------------------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------ASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAP------------ ------------------------------------------------------------------------ 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---------------------NLSLVDSSSSSPSRMNSEGHLHVSGSL------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------QENTPFTFFAVSHFPNQNDNGS RMAASGFTDEKETSKIKA----DPEKLKKLQESLL--------------EEDS------------------- ----EEE--------------G-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------DLC---R---------------------------------------- -----------------------------------------------------ICQI-AGGS-P-S------ ----------------------------------------N--------P-------LLEPCGC-------- ------------------------------VGS----LQ--F-VHQECLKKWLKVKITSGADL--------- --------------------GAVKTC------------EM--C----------------------------- ------------------------------------------------------------------------ -------------------------------KQGLLV----------------------------------- -DL------------GDFNMIEFYQKHQQSQAQNELMNSGLYLV---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------LLLH------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------LYEQ RFAELMR-----LNHNQVE---RERLSR----N------YPQPRTEENENSELGDGNEGS------------ ---------------ISQ-S--Q---------------------------------V--------------- ----------V----------------------------- >sp|Q14139|UBE4A_HUMAN/1-1066 Ubiquitin conjugation factor E4 A OS=Homo sapiens OX=9606 GN=UBE4A PE=1 SV=2 MTDQENNNNIS--SN-----------------------PF-A------AL---------------F------ ------------G-S----L------------------------------ADAKQFAAIQ------------ --------KEQLKQ---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------QSDELPA-------------SPDDS DN------------SVS----------------------------------------ESL------------ --DE---F--------------------------------------------------D------------- -------------------------------------------------YSVAEISRSFRSQQEICEQLNIN HMIQRIFLIT------LDN---SDPS------LKSGNGIPS------------------------------- RCVYLE------------------------------------------------------------------ --------------------------------------------------EM-------------------- ---------------------------------AVELEDQDWLDMSNVEQAL---FA--------------- ------------------------------------------------------------------------ -----------------RLLLQDPGNHLINMTSSTTLNLSADRDAGERHIFCYLYSCFQRA-KEEITKVPEN LLPFAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGAHFEDV--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------TEFLEEVIEA LILDE------------------------------------------------------------------- --------------------------------------------EVRT------------------------ ------------------------------------------------------------------------ -------------FPE-----------------V-------------------------------------- -----------------------------------------------------------------------M IPVFDILLGRIKDLELCQILLYAYLDILLYFTRQKDMAKVFVEY---------------------------- ---------------IQPKDPTNGQMYQKTLLGVILSIS------------------------CLLKT--PG VVEN-----------HGY------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------FL-----N---------PS------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----LLKLCQPFCKP--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------RSSRLLTFNPTYCALKELNDEER KIKNVHMRGLDKETCLIPAVQEPKFPQNYNLVTENLALTEYTLYLGFH---------------RLHDQM--- ------------------------------------------------------------------------ ---------VKINQNLHRLQV--------------------------------------------------- ---------------AWRDAQQSSSPAADNL--REQFER-LM------------------------------ TIY-LSTK--TAMTEPQMLQNCLNLQVSMAVLLVQ---LAIGNEGSQPIELTFPLPDG-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------PL---------- ----------------------------------------------TMDQIRP-NT-ELKEK--IQRW---- --L--------------------------------------------------------------------- ---------------------------A------ERKQQKE--------------QL--------------- -----E---------------------------------- >sp|Q8NHM5|KDM2B_HUMAN/1-1336 Lysine-specific demethylase 2B OS=Homo sapiens OX=9606 GN=KDM2B PE=1 SV=1 MAGPQMGGSAE--DH-----------------------PP-R------KRHAAE------KQKKK------- -----T------------------------------------------------------------------ ------VIYTKCFE--------------------------------FE--SATQRP--I------------- ----------------------------------------------------DRQRYDENEDLSDVEE---- ---------------------------------------------IV-------SVR----GFSLE------ -----E-----------------------------K-------------------L---RSQLYQGD----- 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------------------------------------------------------------------------ -----D----------QEALG--------------------------------------------------- -------------------------------------------KKPKAPALRFLKRTLSNESEE-------- ----------------------SVKSTTLAVDYPKTPTG--------SPATEVSAKWTHLTEFELKGLKALV EKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKT--------------PKN RAVGRPKGKLGPASA--------------------------------------------------------- --------------------------------VKLAA-NRTTAGARRRR----------------------- --------------------------------TRCRKCEACLRTECGEC----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------HFCKDMKKFGGP G----------------------------------------------------------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------FSKGLN-GT------------------------------ PRE-LRHQ--LGPSLRSPPR---------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------VISRPPPSVSPPKCIQMERH--V I----------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------RPPPISP-PPDSLPL---------- ----------------------------------------------DDGAA--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------HVMHRE-V---------------- -------WMA-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------VF----------------------SYL--------- ------------------------------------------------------------------------ ---------------------------------SH---------------QD-------------------- ---------------------LCV-------------CM--------------------------------- ------------------------------------------------------------------------ -------------------------RVCRTWN-----RWCC---------------DKRLWTRI-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------DLNHCKS ITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSW----------------------- ------------------------------IAV--------------------SAL---------------- ------------------C---SSSC------------PL--L----------------------------- ------------------------------------------------------------------------ -------------------------------RTLDVQWV--------------------------------- EGL------------KDAQMRDLLS-----------------PP------TDNRPGQMD--NRS-----K-- -------L---------------------------------------------------------------- ---------------RN-IVELRLAGLDITD-------ASLRLII--------------------------- ---------RH--M---------------------------------------------------------- -------------------------------------PLLS--------------------KLHLSYCNHV- TDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQ--CLSFF------------------------KR-CG--- NI----CHIDLRYCKQ------------VT----------KE-------------------G--CEQF---- ----IAE-----MSV------------------------------------------SVQ-F---------G ---------------QVE-E--KLLQK-------L------------------------------------- -------------------S-------------------- >sp|P21580|TNAP3_HUMAN/1-790 Tumor necrosis factor alpha-induced protein 3 OS=Homo sapiens OX=9606 GN=TNFAIP3 PE=1 SV=1 MAEQVLPQALY------------------------------------------------------------- -------LSN-MRKAVK----I---RE--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------RT------------ --PE-------------------------------------------------------------------- ----------------------D------------------------------------------------- ------------------------IFKP------------T--------------------------NGIIH ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------HFKT--------- ------------------------------------------------------------------------ ----------------------MHRYTLEMFRT------------------------CQFCPQFREIIHKAL ID----------------RN------------------I--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------QATL--ESQKK----------LN- ------------------------------------------------------------------------ -------------------------------W---------------------------------------- ------------------------------------------------------------------------ --------------------------------------CREVRK---------------------------- ---------------LVALKTN----GDGNC--LMHATS------------------------QYMWGVQD- ----------------------------------------------------------TDLVL--------- ------------------------------------------------------------------------ --------------------------------------------RK---ALFST-LKET------------- ------------------------------------------------------------------------ ------------------------------------------------DTRNFKFRW-------------QL ESLKS------------------------------------------------------------QEFVETG LCYDTRN-----WNDEWDNLIKMASTDT---P--MARSG--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------LQYNSLEEIHIFVLC-- ---------------NILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPAQECYRYPIVLGYDSHHF VPLVTLK--DSGPEIRAVPLVNRDRGRFEDLKVHFLTDPENEMKEKLLKEYLMVIEIPVQGWDHGTTHLI-N AAKLDEANLPKEINLVDDYFELVQHEYKKWQENSEQGRREGHAQNPM-EPSVPQLSLMDV------------ --KCETPNCPFFMS--------VNT-QPL---CHE--CS--------------------------------- ---------------------------------ERRQ----------------------------------- --------------------KNQNKLPKLNSKPGPEGLPGMALGASRGEAYEPLAWNPEESTGG-------- ------------PHS--A--------------------------------------PPTAPS---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------PFLFSETTAMKC------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------RSPGCPFTLNVQHNGFCERCHNARQLHASHAPDHTRHLDPGKCQACLQDVT ------------------------------------------------------------------------ -----------------RTFNGICSTCFKRTTAEASSSLSTSL----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------PPSCHQRSKSDPS-RLVRSPSPHSCHRAGNDAPAGCLSQAAR- ----------TPG----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------D-RTGTSKCRKAGCVYFGTPEN-KGF--------------------------------- ------------------------------------------------------------------------ -------------CTLCF------------------------------------------------------ ------------------------------------------------------------------------ --------------------IEYRENKHFAAASGK---------------VSPTASRFQNTIPCLGR----- ---------------------ECGTLGSTMFEGYCQKCFIEAQN---------------------------- ------------------------------------------------------QRFH-------------- ---EAKRTEEQLRSSQRRDVPRTTQ---STS----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------RPK C-------------------------------------------ARA------SC-----KN---------- ----------------------------------------------------------ILACRS-------- ------------------------------E----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------E-----------LCMECQHPNQ------------ -RM------------GPGA----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------HRGEP------------------------------------APED PP----KQ----RCRA-------------------------P-------------------A--CDHF---- ----GNAK---CNG-------------------------------------------YCN-E---------C ---------------F-Q-FKQMYG----------------------------------------------- ---------------------------------------- >sp|Q9C0B0|UNK_HUMAN/1-810 RING finger protein unkempt homolog OS=Homo sapiens OX=9606 GN=UNK PE=1 SV=2 MSKGPGPG-------------------------------G-------SAA---------------SSA--PP A-------------------AT---A-Q-----------V----------L-------------QAQP---- ---EKPQHYTYLK-------E---FRT---------EQCP-LFVQ-HK--CTQHRP--Y------------- ---TC-----------FHWH---------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------------F---------------- ------------------------------------------------------VNQRRRRS------IRRR DG-------------TF----------------------------------------NYS------------ --PD-------------------------------------------------------------------- ----------------------VY------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------CTKYDE---------------------------- ---------------ATGLCPE----GDECP----------------------------------------- --------------------------------------------------------------F--------- -----------------------------------------------------LH----RTT---------- ------------------------------GDTERRY-----HLR-----------Y--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------YKTG IC-----------------------IHETDSKGNCTKNGLHCAFAHGPHDLRSPVYDIRELQAMEALQNGQT -TVEGSIEGQSAGAASHAMIEKILSEEPRWQETAYVLGNYKTEP---------------------------- ------------------------------------------------------------------------ ----------CKKPP--------------------------------------------------------- ------------RLC--------------------------------------------------------- --------------------------------RQGYA-CPYYHNS------KDRRRSP-------------- -------------------------RKHKY-----------------RS----------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------SPCP---- ------------------------------------------------------------------------ -------------------------------------------------------------NVKHGDEWGDP G----------------------------------------------------K------------------ ---CEN------------------------------------------------------------------ ------------------------------------------------------------------------ -------GDAC------------------------------------------------------------- ------------------------------------------QYC------------------HTR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------TE--------QQF-HPEIYKSTK--CND-------------------------------- ---------------------------------MQQS----------------------------------- --------------------------------------------------------------GS-------- ------------CPR--G--------------------------------------PFCAFAHVEQP-PLS- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------DDLQPSSAVSSPTQP------------------- -----------------------------------GPVLYMPSAAGDSVPVSPSSPHAPDLSALLCRN---- ------------------------------------------------------------------------ -------------------SSLGSPSNLC-GS--P------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------------------P--- ------------------------------------------------------------------------ -----------------------------------------------------------G----------SI RKPPNLEGIV----------------------------------F--------------------------- ------------------------------------------------------------PG---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------ESG------------------------------------------------ ---------------------------------L-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -APGSYKKAPGFE----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------REDQVGA----------------------------------- --------------------------------------------------------------EYLKNFKC-- ---------------------------------------------QAKLKPHSLEPRSQEQPLLQPKQDMLG ILPAGSPLTSSISSSITSSLAAT------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------PPSPVGTSSVPGMNANALPFYPTSDTVESVIESALDDLD LNEFGVAALEKTFDNSTVPHPGSITIGGSLLQSS--------APVNIP------GSLGSSASFHSASPSPPV SLSS-------------------------------------------------------------------- -----------------------H------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------FLQQPQGHL--SQS---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------ENT---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------FLGTSAS-HGS--------------------------------- ------------------------------------------------------------------------ -------------LGLNG------------------------------------------------------ ------------------------------------------------------------------------ --------------------MNSSIWEHFA------------------------------------------ -------------------------SGS---------------FSPGTSPAF-------------------- ------------------------------------LSG-PG--------AAELARLRQELDEANS---TIK QWEE---------------SWKQAKQACDAWK-----KEAEEA-GERASAAGAECEL--------------- ------AREQRDALEVQVKKLQEELERLHAGPE----------------PQALPAF--------------SD L-----------------------------------------------------------------EALSLS TLYSLQKQLRAHLEQVDKAVFHMQSVKC---L---------------------------------------- -----------------------------------------------------KCQE-QKRA---------- ----------------------------------------------------------VLPCQH-------- ------------------------------A----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------A-----------LCELCA---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------EG--------------------------S-----------------ECP-I---------C ---------------Q-P-G--RA-HTL------QS------------------------------------ ---------------------------------------- >sp|Q6PCT2|FXL19_HUMAN/1-694 F-box/LRR-repeat protein 19 OS=Homo sapiens OX=9606 GN=FBXL19 PE=1 SV=3 MGMKVPGK-GE--SG-----------------------PS-A------LL---------------------- ------------------------------------------------------------------------ -----------------------------------------------------TPP--M------------- ----------------------------------------------------S------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------SSS-RGPGAGARRRR----------------------- --------------------------------TRCRRCRACVRTECGDC----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------HFCRDMKKFGGP G----------------------------------------------------------------------- --RMKQSCL--LRQ---------------------------------------------------------- --------------------------------------------------------------------CTA- --PVLPHTAVC------------------------------------------------------------- ------------------------------------------LLC------------------GEAG----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------KEDTVEGEEEKFGLSLME---CTI--CN--------------------------------- ---------------------------------EIVH----------------------------------- --------------------------------------------------------------PG-------- ------------CLK------------------------------------M----GK-----------AEG ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------V---IN---------------------------------- -----------------AEIP----------------------------------------NCWECPR---- ------------------------------------------------------------------------ -------------------CTQEGRTSKD-SGEGPGRRRADN---------------------------GEE GASLGSGWKLTEE----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------P-------------------------------------------PLPPPPP------------ ----RRKGPL----------------------------------PAGPPPEDVPGPPKRKEREAGNEPPTPR KKVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPL---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------ASA------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------E-------------------------------------------------- ----------------------------------GPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSD SDSDSSGTSLSEDEAPG------------------------------------------------------- ------EARNGRR----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------PARGSS-GE------------------------------ KEN-RGGR--RAVRPGSGGP---------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------LLSWPLGPAPPPRPPQLERH--V V----------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------RPPPRSP-EPDTLPL---------- ----------------------------------------------AAGSD--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------HPLPRA-A---------------- -------WLR-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------VF----------------------QHL--------- ------------------------------------------------------------------------ ---------------------------------GP---------------RE-------------------- ---------------------LCI-------------CM--------------------------------- ------------------------------------------------------------------------ -------------------------RVCRTWS-----RWCY---------------DKRLWPRM-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------DLSRRKS LTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSW----------------------- ------------------------------LSV--------------------SAL---------------- ------------------G---SAPL------------PA--L----------------------------- ------------------------------------------------------------------------ -------------------------------RLLDLRWI--------------------------------- EDV------------KDSQLRELLL-----------------PP------PDTKPGQTE--SRG-----R-- -------L---------------------------------------------------------------- ---------------QG-VAELRLAGLELTD-------ASLRLLL--------------------------- ---------RH--A---------------------------------------------------------- -------------------------------------PQLS--------------------ALDLSHCAHV- GDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDH--CLPLF------------------------RR-CP--- RL----RRLDLRSCRQ------------LS----------PE-------------------A--CARL---- ----AAA-----GP-------------------------------------------PGP-F---------R ---------------CPE-E--KLLLK-------D------------------------------------- -------------------S-------------------- >sp|Q9H9P5|UNKL_HUMAN/1-680 Putative E3 ubiquitin-protein ligase UNKL OS=Homo sapiens OX=9606 GN=UNKL PE=1 SV=3 MPSVSKAA-------------------------------A-------AAL---------------SGS--PP Q------------------------------------------------------------------T---- ---EKPTHYRYLK-------E---FRT---------EQCP-LFSQ-HK--CAQHRP--F------------- ---TC-----------FHWH---------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------------F---------------- ------------------------------------------------------LNQRRRRP------LRRR DG-------------TF----------------------------------------NYS------------ --PD-------------------------------------------------------------------- ----------------------VY------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------CSKYNE---------------------------- ---------------ATGVCPD----GDECP----------------------------------------- --------------------------------------------------------------Y--------- -----------------------------------------------------LH----RTT---------- ------------------------------GDTERKY-----HLR-----------Y--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------YKTG TC-----------------------IHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQL GGGEGVPDLQPGVLASQAMIEKILSEDPRWQDANFVLGSYKTEQ---------------------------- ------------------------------------------------------------------------ ----------CPKPP--------------------------------------------------------- ------------RLC--------------------------------------------------------- --------------------------------RQGYA-CPHYHNS------RDRRRNP-------------- -------------------------RRFQY-----------------RS----------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------TPCP---- ------------------------------------------------------------------------ -------------------------------------------------------------SVKHGDEWGEP S----------------------------------------------------R------------------ ---CDG------------------------------------------------------------------ ------------------------------------------------------------------------ -------GDGC------------------------------------------------------------- ------------------------------------------QYC------------------HSR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------TE--------QQF-HPE---STK--CND-------------------------------- ---------------------------------MRQT----------------------------------- --------------------------------------------------------------GY-------- ------------CPR--G--------------------------------------PFCAFAHVEKSLGMV- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------NE-------------------------------- ---------------------------------------------------------------WGCHD---- ------------------------------------------------------------------------ -------------------LHLTSPSSTG-SG--Q------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------------------P--- ------------------------------------------------------------------------ -----------------------------------------------------------G----------NA ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------KRRDSPAEGGPR---GSEQDSKQNHLA VFAAVHPPAPSVSSSVASSLASSAGSGSSS------------------------------------------ ------------------------------------------------------------------------ ---------------------PTALPAPPARALP------------------LGPASSTVEAVLGSAL-DLH LSNVNIASLEKDLEEQDGHD--LGAAGPRSLAGS--------APVAIP------GSLPRAPSLHS------- --PS-------------------------------------------------------------------- -----------------------SASTSPLGSLSQPL----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------PGPVG------------------------------------------ ----------------SSAMTPPQQ-PPPLRS---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------EPG---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------TLGSAASSYSP--------------------------------- ------------------------------------------------------------------------ -------------LGLNG------------------------------------------------------ ------------------------------------------------------------------------ --------------------VPGSIWDF-V------------------------------------------ -------------------------SGS---------------FSPSPSPIL-------------------- ------------------------------------SAG-PPSSSSASPNGAELARVRRQLDEAKR---KIR QWEE---------------SWQQVKQVCDAWQ-----REAQEA-KERARVADSDRQL--------------- ------ALQKKEEVE--------------------------------------------------------- ------------------------------------------------------------------------ ----------------AQVIFQLRAKQC---V---------------------------------------- -----------------------------------------------------ACRE-RAHG---------- -------------------------------------------------A-------VLRPCQH-------- ------------------------------H----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------I-----------LCEPCAA--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------TA--------------------------P-----------------ECP-Y---------C ---------------K-G-Q--PL-Q---------W------------------------------------ ---------------------------------------- >sp|Q9Y2K7|KDM2A_HUMAN/1-1162 Lysine-specific demethylase 2A OS=Homo sapiens OX=9606 GN=KDM2A PE=1 SV=3 MEPEEERIRYS--QR-----------------------L--------------R------GTM--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------RRRY-EDDGISD-DE---- ---------------------------------------------IE-------GKR----TFDLE------ -----E-----------------------------K-------------------L---HTNKYNAN----- -----------FVTFMEGKDF--NV----EY------------IQRGGLRD-PL-------I------FKNS DG-------------LG----------------------------------------IKM------------ --PD---P---------------------------------------------------------------- -----------------------D-------------------------FTV-----NDVKM---------- ---------C------VGS---RRMVDV------------M--------------------------DVNTQ K----------------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------GIEMTMAQW---------TRYYETPEEER------------------ ------EKLYNV---------------------------------------------ISLEFSHTRLENMVQ RPSTVD------------------------------------------------------------------ --------------------------------------------------FIDWVDNMWPRHLKESQTESTN AILEMQYP--------------------KVQKY---C----------------------------------- --------------L------------MSVRGC------------------------YTDFHVDFGG----- ------------------TS------------------V--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------WYHI--HQGGK----------VF- ------------------------------------------------------------------------ --------------W-----------------LIPPT----------------------------------- -----------------------------------------------------AHNLELYENWL--LSGKQG -------------------------------------DIFLGDRVSDCQRIELKQGYTFVIPSGWI------ ------------HAVYTPTDT----LVFGGN--FLHSFN--------------------IPMQLKIYNIED- ----------------------------------------------------------RT------------ -------------------------------------------------------------R---------- ------------------------------VPNKFRY-----PFYYEMC-WYVLERYVYCITNRSHLTKEFQ KESLSMDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSP-------------------------------- -------------------------------V-ANGVN------------------L--------------- ------------------------------------------------------------------------ -----D----------YDGLG--------------------------------------------------- -------------------------------------------KTC--RSLPSLKKTLAGDSS--------- -------------------------SDCSRGSHNGQVWD--------PQCAPRKDRQVHLTHFELEGLRCLV DKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPI TKPHTMKPAPRLTPV--------------------------------------------------------- --------------------------------RPAAA-SPIVSGARRRR----------------------- --------------------------------VRCRKCKACVQGECGVC----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------HYCRDMKKFGGP G----------------------------------------------------------------------- --RMKQSCV--LRQ---------------------------------------------------------- --------------------------------------------------------------------CLA- --PRLPHSVTC------------------------------------------------------------- ------------------------------------------SLC------------------GEVD----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------QNE----ETQDFEKKLME---CCI--CN--------------------------------- ---------------------------------EIVH----------------------------------- --------------------------------------------------------------PG-------- ------------CLQ------------------------------------M----D------------GEG ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------L---LN---------------------------------- -----------------EELP----------------------------------------NCWECPK---- ------------------------------------------------------------------------ -------------------CYQEDSSEKA-QK--RKMEE------------SDE------------EAVQAK VLRPL----RSCDEP--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------LTPP----------------------------------P--------------------------- ------------------------------------------------------------HS---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------PTS------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------MLQLIHDPVSPRGMVTRSSPGAGPSDHH- ----SASRD--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------ERF --K--------------------------------------------------------------------- ------------------RRQLLRLQATE------------------------------------------- ------------------------------------------------------------------------ -----------RTMV---------------------------REKENNPSGKKELSEVEKAKIRGSYLTVTL QRPTKELHGTSIVPKLQAITASSA------------NLR--------------------------------- -----------------------------HSPRVL------------------------------------- ---VQHCPARTPQRGDEEG------------LGGEEEEEEEEEEEDDSAEEGG-AARLN------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------GRGSW--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------A---------- ----------------------------------------------QDGDE--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------SWMQRE-V---------------- -------WMS-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------VF----------------------RYL--------- ------------------------------------------------------------------------ ---------------------------------SR---------------RE-------------------- ---------------------LCE-------------CM--------------------------------- ------------------------------------------------------------------------ -------------------------RVCKTWY-----KWCC---------------DKRLWTKI-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------DLSRCKA IVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSW----------------------- ------------------------------SAV--------------------SAL---------------- ------------------S---TSSC------------PL--L----------------------------- ------------------------------------------------------------------------ -------------------------------RTLDLRWA--------------------------------- VGI------------KDPQIRDLLT-----------------PP------A-DKPGQ-D--NRS-----K-- -------L---------------------------------------------------------------- ---------------RN-MTDFRLAGLDITD-------ATLRLII--------------------------- ---------RH--M---------------------------------------------------------- -------------------------------------PLLS--------------------RLDLSHCSHL- TDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQ--TLIYL------------------------RR-IA--- NV----TLIDLRGCKQ------------IT----------RK-------------------A--CEHF---- ----ISD-----LSI------------------------------------------NSL-Y---------C ---------------LSD-E--KLIQK-------I------------------------------------- -------------------S-------------------- >sp|Q6GQQ9|OTU7B_HUMAN/1-843 OTU domain-containing protein 7B OS=Homo sapiens OX=9606 GN=OTUD7B PE=1 SV=1 MTLDMDAV---------------------------------------------------------------- -------LSDFVR-STGAEPGL---ARD-----------L----------LEGK---------NWDVN---- ---AALSDFEQLR-------Q---VHA---------GNLPPSFS---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------EG SG--------------G----------------------------------------SRT------------ --PE-------------------------------------------------------------------- ----------------------KG-------------------------FSD-----REPT----------- ----------------RPP---RPILQR------------Q--------------------------DDIVQ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------EKRLSRGISHASS SIVSLARS--------------------HVSSNGGGG----------------------------------- --------------GSNEHPLEMPICAFQLPDL------------------------TVYNEDFRSFIERDL IE----------------QS------------------M--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------LVAL--EQAGR----------LN- ------------------------------------------------------------------------ -------------------------------WW--------------------------------------- ----------------------------------------------------------------------VS -------------------------------------VDPTSQR---------------------------- ---------------LLPLATT----GDGNC--LLHAAS------------------------LGMWGFHD- ----------------------------------------------------------RDLML--------- ------------------------------------------------------------------------ --------------------------------------------RK---ALYAL-MEKGV------------ ------------------------------------------------------------------------ ------------------------------------------------EKEALKRRW-------------RW Q--QT------------------------------------------------------------QQNKESG LVYTEDE-----WQKEWNELIKLASSEP---RMHLGTNG--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------ANC------------------GGV------ ------------------------------------------------------------------------ --------------------------------------------------ESSEEPVYESLEEFHVFVLA-- ---------------HVLRRPIVVVADTMLRD-SGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHF SALVSMEQKENTKEQAVIPLTDSE---YKLLPLHFAVDPG-------------------KGWEWGKDDSDNV RLASVILSLEVKLHLLHSYMNV------KWIP------LSSDAQAPLAQPESPTASAGDEPRSTPESGDSDK ESVGSSSTSNEG-G---------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------RRKEKSKRDREKDKKRADSVANKLGS-------- ------------FGK--T--------------------------------------LGSKLK---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------KNMGGLMHSKGS------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------KPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAG------------- ------------------------------------------------------------------------ -------------------------------------------------DGPVS------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------EK----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------PPAES------------------------------------------ ----------------VGNGG-SKY-SQEVMQSLSILRTAMQG----------------------------- ------------------------------------EGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLA ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------E------------------------------------ -------------QKQKEAERKIMNGGIG------------------------------------------- --------------------------------------GGPPPAKKPEPDAREEQPTGPPAESRAMAFSTG- ----------YPG----------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------DFTIP---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------RP-------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------SGG----------------- -------GVHCQ-E-PRRQLAGGP------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------CVGG---------------LPPY------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------ATF----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------PRQ C----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------PPG----RP--Y-PHQDS------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------I-----------PSL---EPGS------------ -HS------------KDGLHRGALL-----------------PP------PY---------RVADSYSNG-- ------------------------------------------------------------------------ ------------------YR-------------EPPEPD--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------GWAGGLRGL---------------------------------------P PT----QT----KCKQ-------------------------P-------------------N--CSFY---- ----GHPE---TNN-------------------------------------------FCS-C---------C ---------------Y-R-E--ELRRRE------RE--------------PD-GELL--------------- -----VHR-F------------------------------ >sp|Q8TE49|OTU7A_HUMAN/1-926 OTU domain-containing protein 7A OS=Homo sapiens OX=9606 GN=OTUD7A PE=1 SV=1 MVSSVLPNPTS-AEC---W--------------------A-------ALL---------------H-D--PM TLDMDAVLSDFVR-STGAEPGL---ARD-----------L----------LEGK---------NWDLT---- ---AALSDYEQLR-------Q---VHT---------ANLPHVFN---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------EG R---------------G----------------------------------------PKQ------------ --PE-------------------------------------------------------------------- ----------------------RE-------------------------P-------QPGH----------- ----------------KVE---RPCLQR------------Q--------------------------DDIAQ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------EKRLSRGISHASS AIVSLARS--------------------HVASE---C----------------------------------- --------------NNEQFPLEMPIYTFQLPDL------------------------SVYSEDFRSFIERDL IE----------------QA------------------T--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------MVAL--EQAGR----------LN- ------------------------------------------------------------------------ -------------------------------WW--------------------------------------- ----------------------------------------------------------------------ST -------------------------------------VCTSCKR---------------------------- ---------------LLPLATT----GDGNC--LLHAAS------------------------LGMWGFHD- ----------------------------------------------------------RDLVL--------- ------------------------------------------------------------------------ --------------------------------------------RK---ALYTM-MRTGA------------ ------------------------------------------------------------------------ ------------------------------------------------EREALKRRW-------------RW Q--QT------------------------------------------------------------QQNK--- ----EEE-----WEREWTELLKLASSEP---RTHFSKNG--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------GTG------------------GGV------ ------------------------------------------------------------------------ --------------------------------------------------DNSEDPVYESLEEFHVFVLA-- ---------------HILRRPIVVVADTMLRD-SGGEAFAPIPFGGIYLPLEVPPNRCHCSPLVLAYDQAHF SALVSMEQRDQQREQAVIPLTDSE---HKLLPLHFAVDPG-------------------KDWEWGKDDNDNA RLAHLILSLEAKLNLLHSYMNV------TWIR------IPSETRAPLAQPESPTASAGEDVQSLADSLDSDR DSVCSNSNSNNGKN---------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------GKDKEKEKQRKEKDKTRADSVANKLGS-------- ------------FSK--T--------------------------------------LGIKLK---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------KNMGGLGGLVHG------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------K--MGRANSANGKNGDSAERGKEKKAKSRKGSKEESGASASTSPSEKT--- ------------------------------------------------------------------------ ------------------------------------------TPSPTDKAAGAS------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------PA----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------EKGGG------------------------------------------ ----------------PRGDA-WKY-STDVKLSLNILRAAMQG----------------------------- ------------------------------------ERKFIFAGLLLTSHRHQFHEEMIGYYLTSAQERFSA ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------E------------------------------------ -------------QEQRRRDAATAAAAAAAAAAATAKRPPRRPETEGVPVPERASPGPPTQLVLKLKERPSP GPA--------------------------AGRAARAAAG--------------------------------- ----------GTASPGGGARR--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------ASASGPVPGRSPPA---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------PA-------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------RQS----------------- -------VIHVQAS-GARDEACAP------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------AVGA---------------LRPC------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------ATY----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------PQQ N----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------RSLSSQSYS--P-ARAAA------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------L-----------RTV---NTVE------------ -SL------------ARA--VPGAL-----------------PG------AAGTAGAAE--HKSQTYTNG-- ------------------------------------------------------------------------ ------------------FGALR-DGLEFADADAPTARS--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------NGECGRGGP---------------------------------------G PV----QR----RCQR-------------------------E-------------------N--CAFY---- ----GRAE---TEH-------------------------------------------YCS-Y---------C ---------------Y-R-E--ELRRRR------EA--------------RG--ARP--------------- ---------------------------------------- >sp|Q6IE81|JADE1_HUMAN/1-842 Protein Jade-1 OS=Homo sapiens OX=9606 GN=JADE1 PE=1 SV=1 MKRGRLPSS--SEDS-----------------------DDNG------SL---------------------- ------------------------------------------------------------------------ -----------------------------------------------------STT--W------------- ------------------------------------------------------------------------ ---------------------------------------------SQ-------NSRSQHRRSSCS------ --RHED-----------------------------R-------------------K---PSEVFRTD----- -----------LITAMKLHD---SY----QL------------NPDEYYVL-AD-------P------WRQE WE-------------KG----------------------------------------VQV------------ --PV-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --SPGTIP--------------------QP------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------VARV------------ ------------------------------------------------------------------------ -----------------------------------------------------------------VSE-EK- -------------------------------SLMFIRPKKYIVS-SGSEPPELGYVDIRT------------ -------------------------------------------------------------L---------- ------------------------------ADSVCRY-----DLNDMDAAWLELTNEEFK------------ -------------------------------------------------------------EMGM------P ELD-EYTMERVLEEFEQRCYD-NMNHAIETEE-GLGIE------------------Y--------------- ------------------------------------------------------------------------ -----D----------EDVVC--------------------------------------------------- -------------------------------------------DVC--Q----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------SPDGED---------------------- ----------------------------GNEMVF-----------CDKC----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------NICVHQACYGIL K----------------------------------------------------------------------- --VPEGSWL--CRT---------------------------------------------------------- --------------------------------------------------------------------CAL- --GVQPK---C------------------------------------------------------------- ------------------------------------------LLC------------------PKKGGAMKP -----------------------------------TRSGTKWV----------------------------- -------------------------------------------HVSCALWI------------PEVSIGSPE KMEPITKVSHIPSSRWAL------------------------------------------------------ ------------------------------------------------------------------------ -------------VCSL-------------------------CN---------------------------- ----------EKFG--------ASI---Q---CSVKNCR--------------------------------- ---------------------------------TAFH----------------------------------- --------------------------------------------------------------VT-------- ------------CAF------------------------------------DRGLEMK-----------TIL ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------A---EN---------------------------------- -----------------DEVK----------------------------------------FKSYCPK---- ------------------------------------------------------------------------ -------------------HSSHRKPEE---------------------------------------SLGKG AAQEN----GAPECS--P------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------R-------------------------------------------- ------------------------------------------------------------------------ ----NPLEPF----------------------------------ASL------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------EQN------------------------------------------------ ---------------------------------R-------------------------------------- ------------------------------------------------------------------------ --------------------------------------------E---------E-AHRVSVRKQKL----- -------------------------------------------------QQLEDEFYTFVNLLDVARALRLP EEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLR------------------- -------------------------------------------------QDLERVRNLTYMVTRREKIKRSV CKVQEQ--IFNLYTKLLEQERVSG------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------V---PSSC------------SS--SSLENMLLFN-------------------- --------------------------------------------------SPSVGPDAP------------- -------------------------------KIEDLKWH--------------------SAFFRKQMGTSLV HSL------------KKPHKRDPL--------------------------QN-SPGSE---GKT-----LLK QPDLCGRR---------------------------------------------------------------- ---------------EGMVVPESFLGLEKTF-------AEARLISAQQKNGVVMPDHGKRRDNRFHCDLIKG DLKDKSFKQSH--KPLRSTDVSQRHLDNTRAATSPGVG-QSAPGTRKEIVPKCNGSLIKVNYNQTA------ -VKVPTTPASPVKNWGGF------RIPK-----KGERQ---------------------------------- -----------------QQGEAHDGACHQHSDY--PYLGL------------------------GR-VP--- AK----ER---------------------------------A-------------------K--SKLKSDNE NDGYVPD-----VEM------------------------------------------SDS-E---------S ---------------EASEK--KCIHT-------SS------------TISR-RTDI--------------- -----IRR-SI------LAS-------------------- >sp|Q8TEY7|UBP33_HUMAN/1-942 Ubiquitin carboxyl-terminal hydrolase 33 OS=Homo sapiens OX=9606 GN=USP33 PE=1 SV=2 MTGSNSHITIL-TLK---VL------------------PH-F---------E-------------------- -----SL---------GKQE---------------------------------------------------- ---KIPNK---MSA----------FRN----------HCP-HL-----------DS--V------------- ---GEITKEDLIQKSLG------TCQDCK-------------------------VQG--------------- ------------------------------------------------------------------------ -----P-------------------------------------------------NLWACLE-----NRCSY VGCGESQVDHSTIHSQETK----HY----LT------------VNLTTLRV-WC-------Y------AC-- ----------------------------------------------------------SKEVFLDRKLGTQP SLP--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------HVRQPHQIQ ENSVQD------------------------------------------------------------------ --------------------------------------------------------------------FKIP SNTTLKTPLVAVFDDLDIEADEEDELRAR------------------------------------------- -------------------------------GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGL---- -------------------ARTDKKPAICKSYLKLMTEL--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------WH-K--SRPGS------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------VVPTTLFQGIKTVNPTFR------------------- ------------------------------------------------------------------------ --------------------------------GYSQQ-----DAQEFLRCLMDLLHEELK------------ ----------------------------------------------------E---------QVM----EVE EDPQTITTEETMEED--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------KSQSDVDFQSCESCS NSDRAENENGSRCFSEDNNETTMLIQDDEN-----------------NS----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------EMSKDWQKEKMC NKINKVNSE-------------------------------------------------------GEFDKDRD SISETVDLN--NQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGV------------------------ ------------------------------------------------------------------------ ----NPR---L------------------------------------------------------------- ------------------------------------------SAS------------------PPKSGNLWP GLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTII------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------SSVQCLT------------------------------------------------------- --------------------------------CDR--VS--------------------------------- ---------------------------------VTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGE AYAPQGWIAFFMEYVKRFVVS--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------CVPS------------ ----WFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVK--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------F CKVQNFPEILCIHLKRFRHE---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------LM-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------FS--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------TKISTHVS--------------------------------- ------------------------------------------------------------------------ -------------FPLEG------------------------------------------------------ ------------------------------------------------------------------------ --------------------LDLQPFLAKDSPAQIVTYDLLSVI----CHH--------------------- --------------------------GTA-----SSGHYIAYCRNNLNNLWY-------------------- ------------------------------------EFDDQS--------VTEVSEST-----VQ----NAE AYVL-------------------------FYR-----KSSEEAQKERRRISN-------------------- --LLNIMEPSLLQFYISRQWLNKFKTFAEPGP--IS------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------N-------NDFLCIHGGVPPRKA GYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLY-----------IC--------------------------- -----------------------HTC------------QI--EA---------------------------- ------------------------------------------------------------------------ --------------------------------EKIEKRRKTELEIFIRLNRAF-QKEDS------------- ---------------------------------------------------PATFY---------------- -----------------------------CISMQWFREWESFVK-GK------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------------D GD-----P-PGPID---------------------NTKIA-------------------------------- ------------------------------------------------------------------------ ------VT----KCGNVMLR---------Q----------GA------------------------DS---- ----GQISEE-TWN-------------------------------------------FLQ-SIYGGGPEVIL RPPV--VHVDPDIL-QAE-E--KIEVE-------TR------------------------------------ -------------------SL------------------- >sp|Q9UBN7|HDAC6_HUMAN/1-1215 Histone deacetylase 6 OS=Homo sapiens OX=9606 GN=HDAC6 PE=1 SV=2 MTSTGQDSTTT-RQR---RSRQN---------------PQ--------------------SPPQD------- -----S------------------------------------------------------------------ ----SVTSKRNIKK---------------------------------------------------------- -----------------------GAVP----------------------------------R---------- -------------SIP------------------------------NLAEVKKKGKM--------------- -----------------------------------K-------------------K---LGQAMEED----- -----------LIVGLQGMDLNL------EA------------EALA------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------------G TGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAE-----KEELM---------- ---------L------VHS---LEYIDL------------M--------------------------E-TTQ Y-----------------MNEGELRVLADTYDSVYLHPNSYSCACLASGSVLR------------------- -------------------------------------------------LV--------------------- -----------------------DAV--------------------------LGAEIRNGMAIIRPPGHHAQ HSLMDGYCMFNH---------------------------------------------VAVAARYAQQKHRIR RV---L------------------------------------------------------------------ --------------------------------------------------IVDW------------------ ---DVH------------------------------------------------------------------ ------------------------------HGQ------------------------GTQFTFDQDP----- ------------------SV------------------L--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------YFSIH--RYEQ---------GRF- ------------------------------------------------------------------------ --------------W------------------PHL------------------------------------ ----------------------------------------------------------KASNWS--TTG--- --------------------------------------------------FGQGQGYTINVP--WN------ ------------QVGMRDADY--------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------------IAAFLHVLL PVALEFQPQLVLVAAGFDALQGDPKGEMAAT----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------PAGFAQLT------------------------------------------------ ----------------HLLMGLAGGKLILS------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---LEGGYN--LRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERD NMEEDNVEESEEEGP--------------------------------------------------------- --------------------------------------------------------------------WEPP VLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIM---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------CRL--EE--------------------------------- ---------------------------------LGLA----------------------------------- --------------------------------------------------------------GR-------- ------------CLTLTPRPATEAELLTCHSAEYVGHLRA-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------TEKMKTR------------ELHR---ES---------------------------------- -----------------SNFD----------------------------------------SIYICPSTFAC AQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDV HHGNGTQHMFEDDPSVLYVSLHRYDH--------------------------------------------GT FF---------------------------------------------------------------------- ----------------------------------PMGDEGASSQIGRAAGTGFTVNV--------------- ------------------------------------------------------------------------ -----------------AWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARG------------ ----DPLGGC----------------------------------Q--------------------------- ------------------------------------------------------------VS---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------PEG------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------YAHLTHLLMGLASGRIILILEGGYNLTSIS ESMAACTRSLLGD----------------------------------------------P------------ ------------------------------------------------------------------------ -------PPLLTLP----------------------RPPL-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------SG---------------- --------ALASITETIQ------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------VHRRY--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----WRSLRVMKVEDREGPSSSKL--------VTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEE STPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAIL DQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGT-ELIQTPL---------- ----------------------------------------------ASSTDHQTPPTSPVQGTTPQISPSTL IGSLRTLELGSESQGASESQA-------PGEENLLGEAAGGQDMADSMLMQGSR------------------ ----GLTDQAIFYAVTPLPWCP-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------HLV---A---------------------------------------- -----------------------------------------------------VCPI-PAAG-L-------- -------------------------------------------------D-------VTQPCGD-------- ------------------------------CGT----IQENW-VCLS---------------CYQVYCGRYI NGHMLQHHGNSGHPLVLSYIDLSAWC------------YY--C----------------------------- ------------------------------------------------------------------------ -------------------------------QAYVHH----------------------------------- -QA------------LLDV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------KN------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------IAHQ -----------------------NKFGE----D------MPHPH---------------------------- ------------------------------------------------------------------------ ---------------------------------------- >sp|Q9NQC1|JADE2_HUMAN/1-790 E3 ubiquitin-protein ligase Jade-2 OS=Homo sapiens OX=9606 GN=JADE2 PE=1 SV=2 MEEKRRKYSISSDNS-----------------------DTTD------SH---------------------- ------------------------------------------------------------------------ -----------------------------------------------------AT---S------------- ------------------------------------------------------------------------ ---------------------------------------------TS-------ASR----CSKLPSSTKSG WPRQNE-----------------------------K-------------------K---PSEVFRTD----- -----------LITAMKIPD---SY----QL------------SPDDYYIL-AD-------P------WRQE WE-------------KG----------------------------------------VQV------------ --PA-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --GAEAIP--------------------EP------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------VVRI------------ ------------------------------------------------------------------------ -----------------------------------------------------------------LPPLEG- -------------------------------PPAQASPSSTMLG-EGSQPDWP------------------- ------------------------------------------------------------------------ --------------------------------GGSRY-----DLDEIDAYWLELINSELK------------ -------------------------------------------------------------EMER------P ELD-ELTLERVLEELETLCHQ-NMARAIETQE-GLGIE------------------Y--------------- ------------------------------------------------------------------------ -----D----------EDVVC--------------------------------------------------- -------------------------------------------DVC--R----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------SPEGED---------------------- ----------------------------GNEMVF-----------CDKC----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------NVCVHQACYGIL K----------------------------------------------------------------------- --VPTGSWL--CRT---------------------------------------------------------- --------------------------------------------------------------------CAL- --GVQPK---C------------------------------------------------------------- ------------------------------------------LLC------------------PKRGGALKP -----------------------------------TRSGTKWV----------------------------- -------------------------------------------HVSCALWI------------PEVSIGCPE KMEPITKISHIPASRWAL------------------------------------------------------ ------------------------------------------------------------------------ -------------SCSL-------------------------CK---------------------------- ----------ECTG--------TCI---Q---CSMPSCV--------------------------------- ---------------------------------TAFH----------------------------------- --------------------------------------------------------------VT-------- ------------CAF------------------------------------DHGLEMR-----------TIL ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------A---DN---------------------------------- -----------------DEVK----------------------------------------FKSFCQE---- ------------------------------------------------------------------------ -------------------HS--------------------------------------------------- ----D----GGPRNE--PTS---------------------------------------------------- ------------------------------------------------------------------------ -------------------------EPT-------------------------------------------- ------------------------------------------------------------------------ ----EP------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------SQA------------------------------------------------ ---------------------------------G-------------------------------------- ------------------------------------------------------------------------ --------------------------------------------E---------D-LEKVTLRKQRL----- -------------------------------------------------QQLEEDFYELVEPAEVAERLDLA EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLR------------------- -------------------------------------------------QDLERVRNLCYMVTRRERTKHAI CKLQEQ--IFHLQMKLIEQDLCRGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGHREDPAPGLLS EELLQDEETLLSFM----------------------RDPSLRPGDPARKARGRT------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------RLPAKKKPPPPPP---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------QDGP------ -----GSRTTPDK----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------APKKTWGQD------------------------------ AGS-GKGG--QGPPTRKPPR---------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------RTSSH------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------L--------- ------------------------------------------------------------------------ ---------------------------------PS------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------SP---------------- ------------------A---AGDC------------PI-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------LATPESPPPLAPE---------------- -----------------------------------------------------TPDEAASVAADSD------ -VQVPGP-AASPKPLGRL------RPPR-----E-------------------------------------- ----------------------SKVTRRLPGAR--PDAGM------------------------GPPSA--- VA----ER---------------------------------P-------------------K--VSLHFDTE TDGYFSD-----GEM------------------------------------------SDS-D---------V ---------------EAEDG---GVQR-------GP------------REAG-AEEV--------------- -----VRM-GV------LAS-------------------- >sp|Q96EP0|RNF31_HUMAN/1-1072 E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens OX=9606 GN=RNF31 PE=1 SV=1 MPGEEEERAFL-VAR---EE------------------LA-S------A--L-R-RDSGQ------------ ------------------------------------------------------------------------ ----AFS-LEQLRP----------LL--------------------AS-----SLP--LAARYLQLDAARLV RCNAH-----------GEPRNYLN------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------T----- -----------LSTALNILE---KY----GR------------------NL-LS-------P------QRPR YW-------------RG----------------------------------------VKF------------ --N---NPVFRSTVDAVQGGRDVLRLYGYTEEQPDGLSFPEGQEEPDE-------HQVATVTLEVLLLR--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------TELSLLLQ------------------- -------------------------------------------------NT--------------------- -----------------------HP---------------------------RQQALE-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------QLLEDK VEDDMLQLSEFDPLLREIA----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------PG------------------------------------ ----------------------------------------------------------PLTTPSVPGST--- --------------------------------------------------PGPCF--LCGSA--PGTLHCPS CKQALCPACDHLFHGHPSRA---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------HHLRQTLPGVL QGTHLSPSLPASAQPRPQSTSLLALGDSSLSSPNPASAHLPW----------------------HCAACAM- --LNEPW---A------------------------------------------------------------- ------------------------------------------VLCVACDRPRGCKGLGLGTEGPQGTGGLEP -----------------------------------DLARGRWA----------------------------- -------------------------------------------CQSCTFEN------------EAAAVL--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------CSICERPRLAQP-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------PSLVVDSRDAGICLQPLQQGDAL---LA---------------------------------- -----------------SAQS----------------------------------------QVWYCIH---- ------------------------------------------------------------------------ -------------------CTFCNSS--------------------------------------------PG WV---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------CVM------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------CNRT------------ ------------------------------------------------------------------------ -------SSPIPAQ----------------------HAPR------------PYASSLEKGPPKPGPPRRLS APLPSSCGDPEKQ----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------RQDKMRE----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --EGLQLVSMIREGEAAGACPEEIFSALQYSGTEVPLQWLRSELPYVLEMVAELAGQQDPGLGAFSCQEARR AWLDRHGNLDEAVEECVRT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------RRRKVQELQSLGFGPEEGSLQALFQHGGDVSRALTELQRQRLEPFRQRLWDS GPEPTPSWDGPDKQSLVRRLLAVY-----------------AL----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------PSWGRAELALSLL--------------QETPRNYELGDVVEAVRHSQDRA FLRRLLA--------------QECAVCGWALPHNRMQALTSCECTICPDCFRQHFTIALKEKHITDMVCPAC GRPDLTDDTQLLSYFSTLDIQLRESLEPDAYALFHKKLTEGVLMRDPKFLWCAQCS---------------- -------FGF-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------IYEREQ------------LEA--TCPQ--------- ------------------------------------------------------------------------ ---------------------------------CH---------------QT-------------------- ---------------------FCV---------R---CK--------------------------------- ------------------------------------------------------------------------ ----------------------------RQWEEQHRGRSCE---------------DFQNWKRMNDPEYQAQ GLAMYLQE---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------NGIDC---P---------------------------------------- -----------------------------------------------------KCKF-SY-A-LAR------ ----------------------------------------G----GCMHF-------HCTQC---------- -------------------------------------RH--Q-FCSGCYNA-FYAK---------------- -----------------------NKC------------PEPNC----------------------------- ------------------------------------------------------------------------ -------------------------------R--VKK----------------------------------- -SLHGHHPRDCLFYLRDWT---ALRLQKLLQDNNVMFN--TEPP---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------AGARAVPG---------------------------- ---------------GGC------RVIEQKEVPN-------------------------------------- --------------------GLRDEACGKETPA--GYAGL------------------------CQ------ ------------AHYK------------EY-----------L-------------------V--SLINAHSL DPATLYE-----VEELETA---TERYLH----V------RPQPLA-------GEDPP--------------- ---------------AYQ-A--RLLQK-------LT-----------EEVPL-GQSI--------------- -----PRR-RK-----------------------------