>sp|Q7Z6E9|RBBP6_HUMAN/1-1792 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1 MSCVHYK-FSSK-L-N---YDTVTFDGL--H-----IS--LCD----------------------------- -----------LK--------------------------------K--QIMGREK----------------- -------------------------LKA-ADC--DLQITNAQTKEEY-TD---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------DN-ALIPKNSSVIVRRIPIGGVKSTSKT 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------APAPVPDIT 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------RRRS----------------------------------------FSRSKSPYSGSSYSRSS YTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRR-----------------------------GRGKSR N---------------------------------YRSRSRSHGY---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ HRSRSRSPPYR------R------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------YHSRSRSPQAFRGQ------------SPNKRNVPQ-GE---------TEREYFNRYREVPPPYDMK AYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAAGA-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------QPRPSAN----------------------------------- ------RENFSPER---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------FLPLN--------------------------------------- ------------------------------IRNSPFTRGRR-EDYVGGQS-HRSRNIGSNYPEKLSARDGHN QKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEG---------------------------------- ----------------------------FLNPEL-------------------------------------- ------------------------------------------------------------------------ -------LETSRKSREPTGVEE----NKTDS----------------------------------------- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------KR--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------KR-------------KTEEKGV-DKDFES-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------SSMKISKL-----------EVTE 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------DYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLP KKG--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------TGDSKKS----------NSSPSRDRKPHDHKATYDTKRPNEETKSV DKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETD EAAFEPDY---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------N-------ESD--------SESNVSVK------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ EEESSGNI--------SKD-------LK--------------------------DKIVE------------- --------------KAKE-SLDTAAVVQVGISR--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NQSHSSPSV-SP-----SRSHS--PSGSQ------------------------------------------ -------------------------------TR----SHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKH KKHAGTEV------------------------ELE------------------------------------- --------------------------KSQKHKHKK------------------------------------- ---------------------------------------------------------------KK------- ------------------SKK-NKDKE-KEKEKD-------------------------------------- ------------------------------------------------------------------------ -------------------------------DQ------------------K-----------VKSV----- -------TV--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------ >sp|P38398|BRCA1_HUMAN/1-1863 Breast cancer type 1 susceptibility protein OS=Homo sapiens OX=9606 GN=BRCA1 PE=1 SV=2 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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--------------VLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQV CSETPDDLLDDGEIKEDTSFA--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------EN-------------D---IKE-SSAVFSKS------ ------------------------------------------------------------------------ ------------------VQK--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------GE--LS--R----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------S------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------R-TLKYFL-----------GIAGGKWVVSYFWVTQSIKERKMLNEH DFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPF-----------------T------NM-PTD-- -------------------QL---------EW-------------------M---------V-QLCG----- -----------------ASVV-----------------K-ELSSFTLGTGVHPIVVVQPDA-------WT-- -----------------EDNGFHA-------------------------IG---QMC-----EAPVVTREWV LDSVALYQCQELDTYLIPQIPHSH------------------------------------------------ ---------------------Y-------- >sp|Q14527|HLTF_HUMAN/1-1009 Helicase-like transcription factor OS=Homo sapiens OX=9606 GN=HLTF PE=1 SV=2 MSWMFKR-D-PV-W-K---YLQTVQYGV--H-----GN--F------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -PRLS----YPTFFPRFE--------------FQDVI----------------------------------- ------------------------------------------------------------------------ ------------------PPDDFLTSDEE-----VD------------------------------------ ----------------------------------------------------------SVLFGSLRGHVVGL 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------VSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHG GILADDMGLGKTLTAIAVILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSK------ --DASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIESSDSEEIET-------------------- 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------------------------------GKPVLE-L---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------P-------------------------------------------------ERKVFIQH -ITL-------------------------------------------------------------------- -----------------------------------------SDEERKIYQSVKNEGRATIGRYFNEGTVLAH YADVLGLLLRLRQICCHTYLLTNAVSSNGPSGNDTPEELRKKLIRKMKLILSSGSDEECAICLDSLT----- ------------------------------------------------------------------------ -----------------------------------------------------------------------V PVITHCAHVFCKPCICQVIQNEQPHAKCPLCRNDIHEDNLLECPPEELARDSEKKSDMEWTSSSKINALMHA LTDLRKKNPNIKSLVVSQFTTFLSLIEIPLKASGFVFTRLDGSMAQKKRVESIQCFQNTEAGSPTIMLLSLK AGGVGLNLSAASRVFLMDPAWNP---AAEDQCFDRCHRLGQKQEVIITKFIVKDSVE--------------- ------ENMLKIQNK--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------KREL-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------AAGAFGTKKPNADEMKQ---------------AK--I-NEI----- ----------------RTLIDL-------- >sp|Q149N8|SHPRH_HUMAN/1-1683 E3 ubiquitin-protein ligase SHPRH OS=Homo sapiens OX=9606 GN=SHPRH PE=1 SV=2 MSSRRKR-APPV-RVDE-E------------------K--RQQ----------------------------- ------------------------------------------------------------------------ -------------------------------L---------------------------------------- -HWNMHE---DR---RNE------P----------------------------------------------- ------IIISDDDEQPCPGSDTSSAHYIIL----------------SD------------------------ ---S--------------LK-EE-------VA----------HRDK----------KRCSKVVSFSKP---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------IEKEETVGIFSPLSVKL---------- -----N-IVISPYHFDNS--------------WKAFLG---------------------------------- --------------------------------ELTLQLLPAQSLIE-NFS---------------------- ER--------------------------------------------------------------SITL---- ------------------------------------------------------------------------ -----------------------------------------------------------------MSSESS- -----------NQFLIYV---------------------------HSK------------------------ --------GEDV------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------EKQKKEPM------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------SICDKGILVESSFSGEM------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------LEDLGWLQKKRR-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------IKLYQK---------------------------------- -------PEGNHIIKV-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------GIYLLE----------------------------------A-------- ------------------------------------------------------------------------ -------------------------------------------G---LAKLD-FLS---------------- ------------------------------------------------------------------------ -----------DANS---------------R----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MKKFN 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------------------------------------------------------------------------ ----------DTDSEYLPSDTSDDDDDPYYYYYKSRRNRSKLRKKLVP------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------ST--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------KKGKS- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------QPFI------NP----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------DSQGHCPATSDSGITDVAMSKSTCISEF------------- ---------------NQEHETEDC-----AESLNHADSDV-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------PPSNTMSPFNTSDYRFECIC---------------------- ------------GELDQIDRKPRV------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------QCLK--- ---------------------------CHLWQHAKCVNY-DEKNLK-------------------------- ------------------------------------------------------------------------ ----------------------------IKPF---------------------------------------- -----------------------------YCPH--------------------------------------- ------------------------------CLVAM------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------EPVSTRATLIISPSSI C----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------HQWVDEINRHVRSSSLRVLVYQGVKKDGFLQP HFLAEQDIVIITYDVLR------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------SELNYV DIPH-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------SNSEDGRRLR------------------------------------------------ ---------NQKRYMAIPS----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------PLVAVEWWRICLDEAQMVECPT------------------------------------------- -------------------------------------------------------VKAAEMAQRLSGINRWC ISGTPV-QR------------------------------GL------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---EDLFG-----------LVVFLGIEP-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------YC--------------------------------VKHWWVRLLYRPYCKKNPQHL----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------YSFI AKILWRSAKKDVIDQIQIPPQTEEIHWLHFSPVERHFYHRQHEVCCQDVVVKLRKISDWALKLSSLDRRTV- ---TSILYP-LLRLRQACCHPQA------------------------------------------------- ------------------------------------------------------------------------ -------------------------VRG-----------EFLPLQKST----------------------MT MEELLT--------------------------------------SLQKKCGTECEEAHRQ---LVCA----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------LNGLAGIHIIKGE------------- --------------------------------------------------------------------YALA AELYREV----------------------LRSS--------------------------------------- -------------EEHKGKLKTDSLQRLHATHNLMELLIARHPGIPPTLRDGRLEEEAKQLREHYMSKCNTE 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------NVIHRA----------------------------------- ------------------------------------------------------------------------ -------------------IEFTIDEELVQRVRNEITSNYKQQTGKLSMSEKFRDCRG-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LQFLLTTQMEEL---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------NKCQKLV---------------------------REA-------- -VKNLEG----------------------------------------------------------------- -----------------PPSRNV----IESATVCH-------------LRPAR-----------L------- -PL--NCCVFCKADELFTEYESKLFSNTVKGQTAIFEEMIEDEEGLVDDRAPTTTRGLWAISETERSMKAIL SFAKSHRFDVEFVD---------------------------------------------------------- -------------------------------EGSTSMDLFEAWKKEYKLLHE-------------------- ------------------------------------------------------------------------ ----------------------YW------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------MALRNRVSAVDELAM---------------------------------- --------------------ATERLRVRDPREP--KP----------------------------------- -----------------------------------NPPVL--------------HI--------IE------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------AHE--------------------------- --L--------QAIGRVHRIGQT--KPTIVHRFLIKATIEERMQAMLKTAE---RS----HTNSSA--KH-- ----------------------------------------------------------SEASVLTV-A-D-- ----LADL------FTKETEELE------- >sp|P53804|TTC3_HUMAN/1-2025 E3 ubiquitin-protein ligase TTC3 OS=Homo sapiens OX=9606 GN=TTC3 PE=1 SV=2 MDNFAEG-DFTV-A-DY-A-------LL--------ED--CPH----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------VDDCVFAAEFM--------SNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDIC---S IWCSKPISVLQ--------DYCDAIKINIFWPLL----------FQH------------------------- ------------------------------------------------------------QNSSVISRLHPC VDANNSRASEINLKKLQ------------------------------------------------------- --HLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGDVTILTKLGSIDNCWPMLSI FFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIA---------------II- ------------------------------------------------------------------------ ----------YYTRAIEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGE YDWALQANIKAQKLCKNDPEGIKD--------L-----------IQ-------------------------- --Q--------------------------------------------------------------------- --------------------------------------------HVKLQKQ--------------------- ---------------------------IED---------------------LQGRTA-NKDPIKAFYENR-- -------AYTPRSLSAPIFTTS------------------------LNFVEKERDFR--------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ VIIEESQPQKIKMLLEKFVEECKFPPVPDAICCYQK------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------CHGYSK-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ --------------QYCKI----------------EF----------HMNCWKKL--KTTTFNDKIDKDFLQ -GICLTPDCEGVISKIIIFSSG-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------GEVKCEFEHKVIKEKVPP--RP---------------------------- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------TEHPFISASCLDWPVP AFDIITQWCFEIKSFTERHAEQGKALL--------------------------------------------- --------IQES------------------------------------------------------------ -----------------KWKL-PHLLQLPENYNT-----------I-------------------------- ----------------------------------------FQYYHRKTCSVC-----------TKV-PKDPA --VCLVCGTFVCLKGLCCKQQSY----CECVLHSQNCGAGTGIF-LLI--------NA--SVIIIIRGH-RF CLWGS-VYLDAHGE-EDRDLR----------------RGKP-LYI-------------------CKERYKVL 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------LNIDTIDSHSYDTSSVASSDSGD RTNLKRK----------------------------------------------------------------- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------G---------------------------- -----------------------------------------L------------------------------ -----------------------------------PTAIAVSSLIAVGTSHGLALIFGKDQNQ--------- ----------------------------------------ALRLCLGSTSVGGQYGAISALSINNDCSRLLC GFAKGQITMWDLASGKLLRSITDAHPPGTAILHIKFTDDPTL--AICND----------------------- ----------------------------------------------------------SGG--------SVF EL-TFK------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------RVMGVRTCESRCLFSGSKG----------EVCCIEP-LHSKPELKDHPITQF-- -----SLLAMASLTKIL------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------VI---------GLKPSLKVW------ -----------------MTFPYGR------------------------------------------------ ----------------------------MDPSSVPLLAW--------------------------------- ---------------------------HFV-AVQNYVNPMLAFCRGDVVHF--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------L-LVKRDESG------------- ---------------AIHVTKQKHLHLYYDLINFTWINSRTVVLLDSVEKLHVI------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------DRQTQE---ELETVEISEVQL----VYNSSHF-------------- ----------------------------------------KSLATGGNVSQALALVGEKACYQSISSYGGQI FYLGTKSVYVMMLRSWRERVDHLLKQDC-----LTEALALAWSFHEGKAKA--------------------- -------------------------------------VVGLSGDASKR------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------KAIVADRMVEILFHYADRALKKCPDQGKIQVMEQHFQDMVPVIVDYCLLLQRKDLLFSQMY DKLSENSVAKGVFLECLEPYILSDKLVGITPQVMKDLIVHFQDKKLMENVEALIVHMDITSLDIQQVVLMCW ENRLYDAMIYVYNRGMNEFISPMEKLFRVIAPP---------------------------LNAGKTLTDEQ- ---VVMGNK-LLVYISCCLAGRA------------------------------------------------- -------YPLG------------------------------------------------------------- ------------------------DIPE-----------DLVP----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------LVKNQVFEFL IRLHSAEASPEEEIYPYIRTLLHFDTREFLNVLALTFEDFKNDKQAVEYQQRIVDILLKVMVENSDFTPSQV GCLFTFLARQLAKPDNTLFVNRTLFDQVLEFLC--------------------------------------- -------------SPD-------------------------------------------------------- ---DDSRHSERQQVLLELLQA--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------KAMD---------------------------H I----------E--ELVSLKPC-------------------------------------------------- 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---------------------------QISPCITEQFIELLCQFNPTQVIETLQVLECYRLEETIQITQKYQ LHEVTAYLLEKKGDIHGAFLIMLERLQSKLQEVT---------------------------HQG-------- -ENTKED----------------------------------------------------------------- -----------------PSLKDVEDTMVETIALCQRNS---------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------------H N-----------------------------------LNQQQREALWF------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------QPSSIPPCALVSQPTVQF ILQGSLPLVGCGAAQTLAPVPAAL------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------YDTYPPLEKKKVDMSVLT SEAPPPP----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------SLECSLVD------------IRPAG----------------------- -----------------------------GSD----KWTA--TACD-------------------------- ------------------------------------------------------------------------ -----------C--------LS-LYLT--------GAVA--------------------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------LAEYDDGLWYRAKIV---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------A------------------------------------------IKE------- ------------------FNPLSILVQ-FVDYGS-------------------------------------- ---------------------------------------TAKLTLNRLCQIP-----S------HL-MRYP- -------------------AR---------AI-------------------K---------V-LLAGFKP-- -------PLRDLGETRIPYCP-----------------K-WSMEA---------------L-------WAMI DCLQGKQLYAVSMAPAPEQIVT-------------------------------------------------L --------------YDDEQHPVHMPLVEMGLADKDE------------------------------------ ------------------------------ >sp|Q09472|EP300_HUMAN/1-2414 Histone acetyltransferase p300 OS=Homo sapiens OX=9606 GN=EP300 PE=1 SV=2 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------------------------------------------------------------------------ ------SKVEDC-KM----------------------------------------ESTETEERS-------- -------TELKTEIKEEEDQPSTSATQSSPAPGQSKK-----------------------------KIFKPE ELRQALMPT--------------------------------LEAL--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ YRQDPESLPFR------QPVDP------------QLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVD DIWLMFNNAWLYNRKT-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------SR--------- ------------------------------------------------------------------------ ----------------------------------------VY--KYCSK----------------------- ----------------------------------------------------------LSEVFEQEIDPVMQ SLGYCCGRKLEFSPQTLCCY------------GKQLCTIPR-DA---------TYYSYQ------------- ---------------NRYHFCEKCFNEIQGESVSLGDDPS-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------QPQTTIN----------------------------------- ------KEQFSKRKNDTLDPELFV------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------ECTE--- ---------------------------CGRKMHQICVLHHE--IIW-------------------------- ------------------------------------------------------------------------ ----------------------------PAGF---------------------------------------- -----------------------------VCDG--------------------------------------- ------------------------------CLKKSARTRKE-NKFSAKRL-PSTRLGTFLENRVNDFLRRQN HPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYG---- -----SDCPP---PNQRRVYISYLDSVHFFRPKC-------------------------------------- ------------------------------------------------------------------------ -------LRTAVYHEILIGYLEYVKKLGYTT----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------ICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLEQGL VEAALVSKISSPSDKKIPAKKESCPNT--------------------------------------------- -----------------------------------GRDKDHLLKYNVGDLVWSKVSGYPWWPCM-------- -----------VSADPLLHSYTKLKG-QKKSARQYH------------------------------------ --------VQFFGDAPERAW----------------------------------------------IFEKSL V-AFE----GE------------------------------------------------------------- ------------------------GQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEE---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------AASMSVEERKAKFTFLYVGDQLHLNPQVAKEA GIAAE--------------------------SLGEMAE--------------SSGVSEE-AAENPKSVREEC IPMKRRRRAKLCSSAETLESHPD-----------------------IGKSTPQKTAEADP------------ ------------------------------------------------------------------------ -----------------------RRGVGSPPGRKKTTVS--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------MPRSRKGDA--------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------ASQFLVFCQKHRDEVVAEHPDASGEE IEELLRSQWS-------------------------------LLS---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ EKQRARYNTKF------ALVAP-------------VQAEEDSGNVNGKKRNHTKRIQDPTEDAEAED--TPR KRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSS PSASLTENEVSDSPGDEPSE-------SPYESADETQTEV-SVSSK---KSER-G----------------- ------------------------------------------V----------------------------- -----------------------------------------T------------------------------ -----------------------------------AKK-----------------------EY--------- ------------------------------------------------------------------------ ----------------------------------------VC--QLCEK----------------------- ----------------------------------------------------------PGS--------LLL CEGPCCGAFH------LACL--G--LS-RRPEGRFTCSECA-SG---------------------------- -----------------IHSC--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------F------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------VCKESKTDVKRCVVTQ--- ---------------------------CGKFYHEACVKKYPLTVFE-------------------------- ------------------------------------------------------------------------ ----------------------------SRGF---------------------------------------- -----------------------------RCPL--------------------------------------- -----------------------------HSCVSCHASNPSNPRPSKGKMMRCVR----------------- ------------------------------------------------------------------------ -----------------------------------------------CPVAYHSGDACLAAGCSVIASNSII CTAHFTARKGKRHHAHVNVS--------------------------WCFV---------------------- ---------------------------CSKG----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------G------ 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-------------------NI--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------QK-------------MKHEIGE-FPVFF-FG------ ------------------------------------------------------------------------ ------------------SKD--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------YYWTHQ--A----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------R------- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------VFPYM------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------EG--DRG---------SRYQGVRGIGRVF-----------K--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------NALQEA------------------------------EARFR EIKLQREAR--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------ETQE------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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-------------DGTAFSCTPDGRSYCCE------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------HD----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------LG------- ------------------AAS-VRSTK-TEK-----------PPPE-------------------------- ----------------------------------------PGK----------------------------- ------------------------------------------------------------------------ -------------------------------------------PK---------------G-------KRRR RRG-------------WRRVTE-----------------------------------------GK------- ------------------------------------------------------------------------ ------------------------------ >sp|Q99590|SCAFB_HUMAN/1-1463 Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2 MKKKTVC-TLNM-G----------------D-----KK--YED----------------------------- -----------ME--------------------------------G--EENGDN------------------ ----------------------------------------TI-------STGL------------------- -LYSE------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------AD--------------RCPICLNCLLEK EV-GFP-ESCNHVFCMTC--------------ILKWA---ETLASCPI-----DRKPF-------------- -----------------QAVFKFS--------A-----------LE-GYV---------------------- KVQ----VKKQLRETKDKKNENSFEK--------------------------------------QVSCHENS KSCIRRKAIVREDLLSAKVCDLKWI---------HRNS---------------------------------- -----------------------------L---------------------YSETGG-KKNAAIKINKP--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------QR--------------SNWS--TNQ----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------CFRNFFSN MFSSVS--------------------------------HSG------------------------------- ---------------ESS------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------FT--YRAYCTEFIEASEISA---------------- ------LIRQKRHELELSWFPDTLPGIGRIGFIPWN----------------------------------VE TEVLPLIS---------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------------------SVL-----PR- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------TIFPT------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------STISFEHFGTSC KGYALAHTQEGEEKKQTSGTSNTRGSRRKPAMTTPTRRSTRNTRAETASQSQRSPISDNSGCDA-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------PGNSNP----------- --SLS--------------VPSSAESEKQTRQAPKRKSVRRGRKPPLL------------------------ ---------------------------------------------------KKKL----------------R -----------------------------------SS-------------------VAAPEKSSS------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------NDSVDEET-----------------------------AESDTS 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------------------------------------------------------------------------ ------ENQSANCLKSCNEQ------------IEESEKHTA-NY---------DTEERVGSSSSESCAQDLP VLVGEEGEVKKLENTGIEANVLCLESEISENILEKGGDPL-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------EKQDQIS----------------------------------- ------GLSQSEVKTDVCTVHLPN------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------DFPT--- ---------------------------CLTSESKVYQPVSC--PLS-------------------------- ------------------------------------------------------------------------ ----------------------------DLSENVESVVNEEKITESSLVEITEHKDFTLKTEELIESPKLES SEGEIIQTVDRQSVKSPEVQLLGHVETEDVEII--------------------------------------- ------------------------------ATCDTFGNEDF-NNIQDSEN-NLLKNN--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------LLNTKLEKSLEE----KNESL----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------T------ -----------------------------------E-H---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------P-------------------------------------------------RSTE-LPK -THI-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------EQIQKHFSEDNNEMIPMEC DSFCSDQNESEVEPSVNADLKQMNENSVTHCSENNMPSSDLADEKVETVSQPSESPKDTIDKTKKPRTRRSR FHSPSTTWSPNKDTPQEKKRPQSPSPRRETGKESRKSQSPSPKNESARGRKKSRSQSPKKDIARERRQSQSR SPKRDTTRESRRSESLSPRRETSRENKRSQPRVKDSSPGEKSRSQSRERESDRDGQRRERERRTRKWSRSRS HSRSPSRCRTKSKSSSFGRIDRDSYSPRWKGRWANDGWRCPRGNDRYRKNDPEKQNENTRKEKNDIHLDADD PNSADKHRNDCPNWITEKINSGPDPRTRNPEKLKESH---------------------------WE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------ENRNENS------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------GNSWNKNFGSGWVSNRGRGRGNRGRGTYRSSFAYKDQNENRWQNRKP LSGNSNSSGSESF---------------------------------------------------K--F---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -VEQQSY-K--------------------------------------------------------------- RKSEQEFSFD----TP--AD-------------------RSGWTSASSWAVRK-----------T------- -LP--ADVQNYY------------------------------------------------------------ -------------S---------------RRGRNSSGPQSGWMKQEEETSGQDSSLKDQTNQQVDGSQLPIN M-----------------------------------MQPQMNVMQQQ------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----MN----------------------------------------------------------------- ----AQ------------------HQ--PM------NIFPYPV----------G------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------V--------------H----------------- ------------------------------------------------------------------------ -----------------------APLM--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------NI-------QR--------------------------NPFNI------------- --------------HPQL-PLHLHTGVPLMQVA--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -TPTSVSQGLPPP-----PPPPP--PSQQV------------------------------------------ -------------------------------NY----IAS-----------QPDGKQLQGIPSSSHVSNNMS TP--VLPA------------------------PTA------------------------------------- --------------------------APGNTGMVQGPSSGNTSSSSHSKASNAAVKLAESKVSVAVEASADS SKTDKKLQIQEKAAQEVKLA------------------------------------------IKP------- ------------------FYQ-NKDIT-KEEYKE-----------I-------------------------- ----------------------------------------VRKAVDKVCHSK-----S------GEVNSTK- -------------------------------VA------------------N-----------LVKA----- -------YVDKY------------------------------KYS--------------------------- --R--------KGS-----------------------------------QK---KTL-----EEPVST---- -----------------------------------------EK----------------------NI----- -----------------------------G >sp|Q12873|CHD3_HUMAN/1-2000 Chromodomain-helicase-DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=CHD3 PE=1 SV=3 MKAADTV-ILW-----------------ARS-----KNDQLRI----SFPP--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -GLCWGD---RM---PD------------------------------K------------------------ ---------D-----------D--------I--------------------------------------RL- -----------LPSALGVKKRKR-------GP-----KKQKENKPGKPRKR-------------KKR----- ------------------------------------------------------------------------ ----------------------------------D------------------------------------- -----------------------------------------SEEEFGSERDEY---------------RE-- ------------------------------------------------------------------------ ------------------------------------------------------K----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------SESGGSE--YGTGPGRKRR---------------------RKHREKKEKKTKRRK KGEG---DGGQKQVEQKSSATLLLTWGL-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------EDVEHVFSEEDYHTLTNY------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------KAFS QFMRPLIA---------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------------------KKN-----PKI PMS--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------KMMTILG----AKWREFSANNP FKGSAAAVAAAA--AAAAA-AVAEQVSAAVSSATPI------------------------------------ -----------------------------------------------------AP--SGPPAL--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------PPPPAADIQ PPPIRRAK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------TKEGKGPGHKRRSKS------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------P-RVPDG------------------------ ---------------------------------------------------RKKLRGKKMAPLKIKLGLLGG ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------KRKKGGS-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------YVFQSDEGPE-PEAEESDLDSGSVHSASG RPDGPVR-T-KKLKRGRPGRKKKK----VLGCPAVAGEEEVDGY---------------------------- -----------------------------------------E------------------------------ -----------------------------------TDH-----------------------QD--------- ------------------------------------------------------------------------ ----------------------------------------YC--EVCQQ----------------------- ----------------------------------------------------------GGE--------IIL 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----------------SWAKELQLEIFHLV-MYRNYQ-------------RKNDMDE-PPPLD-YG------ ------------------------------------------------------------------------ ------------------SGEDDGKSDKRKVKDPHYAE-------MEEKYYR-------------------- ----------------FGIK-------------------P-EWMTVHRII-NHSVDKKG------------- ---------------NYHY----------------------------------LVKWRDLPYDQSTWEEDEM NIPEYEEHKQSYWRHR--E----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------L------- ---------------IMGEDPAQPRKYKK------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------KKKEL---QGD---GPPSSPTNDPTV----KYETQPR-------------- ---------------------------------------------------------------FITATGGTL HMYQLEGLNW-LRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLS------------ --------------------TIINWEREFQMWAPKFYVVTYTGDKDSRAIIRENEFSFEDNAIKGGKKAFKM KREAQVKFHVLLTSYELI------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --TIDQAALGSIRWACLVVDEAHRLKNNQ------------------------------------------- -------------------------------------------------------SKFFRVLNGYKIDHKLL LTGTPL-QN------------------------------N-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --LEELFH-----------LLNFLTPE--------------------------------------------- --R--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------FN--------------------------------NLEGFLEEFADISKEDQIKKLHDLLG ---------------------------------PHMLRRLKADVFKNMPAKTELIVRVELSPMQKKYYKYIL TRNFEALNSRGG------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------GNQ- ---VSLLNI-MMDLKKCCNHPYL------------------------------------------------- -------FPVA------------------------------------------------------------- ------------------------AMES-----------PKLPSGAY------------------------- -----EGGALIK--------------------------SSGKLMLLQKMLRKLKEQGHRV---LIFSQMTK- -----------------------------------------------------------------MLDL--- ------------------------------------------------------------------------ LEDF-LDYEGYKYERIDGGITGALRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPH- -----------------------------------------NDIQAFSRAHRIGQ--------------ANK VMIYRFV----------------------TRAS--------------------------------------- -------------VEE-------------------------------------------------------- ---RITQVAKRKMMLTHLVVR--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------PGLGSKAGSMSKQELDDILKFGTEELFKDEN-E--G--------------- ----------------------ENKE-EDSSVIHYDNEAIARLLDRNQDATEDTDVQN---MNEYLSSFKVA QYVV--REEDKI--EEIEREIIKQEENVDP--DYW---------------------------------E--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------KLLRHH---------------------------YE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----QQQEDLARNLGKGKRVRKQVNYNDAAQ---------------------------------------- ------ED---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----QDNQS--------------------------------------------------------------- --------------EYS--------------VGS-------------------------------------- ------------------------------------------------------------------------ --------------------EEEDEDFD-------------------------------------------- -------------------------------------------------------------------ERPE- --G--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------RR---QSKRQ---------------------------- ----------------LRNEKD-------------------------------------------------- --------------------------------------KP--L-PPLLAR---------------------- ------------------------------------------------------------------------ -----------VGGNIEVLGFN-TRQRKAFLN----AVM--------------------------------- ------------------------------------RWGMPPQDAFTTQWLVRDLRGKTEKEFK-------- ------------------------------------------------------------------------ ------------AYVSLFMRHLCEPGADGSET---------------------------------------- ------------------------FADGVPRE---------------------------------------- -----------------------GLSRQQ------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VLT---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------RI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------G V-----------------------------------MSLVKKKVQEFEHING-------------------- ------------------------------------------------------------------------ ----------------------RWSMPELMP----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------DPSADSKR----------------------------------SS RAS--SP------------------TKT-------------------------------------------- SPTTPEA-----------------------------SATNS----------------PC------TSKPATP AP---------------------------------------------------------------------- --------SEKGEGI---RTPL---------------------------------------------E---- ----KEEAENQEE----------------------------------------------------------K PEKNSRIGEKMETEA--DAPS--------------------------------PA----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ PSLGERLEPRKIPLEDEVP-GVPGEMEPEPGYRG--------------------DREKSATESTPGERGE-- --------EKPLDGQEHRERPEGETGDLGKREDVKGDRELRPG-PR---------------DEPRSNGRREE KTEKPR-------------FM--------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------FNIADGGFTELH---------------TLWQNEER AAISSGKLNEI-------------------WHRR-----HDYWLLAGIV---L-------------HGYARW ----------------------Q-------------------------------DIQNDAQFA--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------IINEP------------------------------------------FK----------------- TEANKGNF---------LEM-------K--------------------------NKFLA------------- --------------RRFK-LLEQALVIEEQLRRAAYLNLSQEPAHP-------------------------- -----------------------------------------------------------AMALHARF----- -----------------------AEAECLA-ES--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --HQH-LSKESLAGNKP------------ANAVLHKVLNQLEELLSDMKADVTRL----------------- ---------------------------------------------------PATL----------------- -----------------------------SRIP--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------PIAARLQM S----------------------------------------------------------------------- --------------------------------------------------------E--------------- ------------------------------------------------------------------------ ------------------------RSILSRLASKG---T-EPHPT---------------PAYPPGP-YA-- -----------TPPGYGAA----FSAAPVG--ALAAAGAN-----Y-----S--QMPAG-SFITAATNG--- -------------------PP---------------------V-LVK-----------KE--K-EMVGAL-- ----VSDG------LDRKEPRAGEVICIDD >sp|Q03112|MECOM_HUMAN/1-1230 Histone-lysine N-methyltransferase MECOM OS=Homo sapiens OX=9606 GN=MECOM PE=1 SV=3 MRSKGRA-RKLA-T-N--------NECV--Y-----GN--YPE----------------------------- -----------IP--------L----------------------EEM--P-DADG-----VASTPSLN---- ----------------IQ---------E-PCSPATS-------SEAFTPKEGS------------------- -PYKAPI---YI---PDD------I----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------PIPA--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------EFEL---------------------- ---------RESN----------------------------------------------------------- ------------------------MPGAGLGIWTKR------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------K---------------------- ----------------------IEVGEKFGPYVGEQRSNLKDPSYGWEILDEFYNVKFCIDASQPDVGSWLK YIRFAGCYDQHNLVACQINDQIFYRVVAD------------------------------------------- --------------------------------------------------------IAPGEELLLFMKSEDY ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------PHET----------------MAP---------------------DIHEE-- ---------------------------------------------------------------------RQY RCED------------------------CD------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------QLFESKAELADHQKFPCSTPHSAF------------- ---------------------------------------------------------------SMVEEDFQQ KLESENDLQEIHTI---------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------------QECKECDQV- FPDLQSLE---------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------------------KH-M------- --------------------------------------L--------------------------------- ------------------------------------------------SHTEERE------------YK--- ------------------------------------------------------------------------ ---------------CDQCP------------KAFNWKSNL------------------------------- -----------------------------------------IRHQMSH------------------------ ------------------------------------------------------------------------ ---------------------------------DSGKHYECENCAK-------------VFTDPSNLQRHIR SQHVGARAHACPECGKTFATSSGLKQH--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------KHIHSSVKPFICEVCHKSYTQFSNLCRHK---------------- ------------------------------------------------------------------------ --------------------------------RMHADCRTQIKCKDCGQMFS-TTSSLNKHRRF-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------CEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGL ADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPAT QDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKE KFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAV---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------SGAVNDSIKAIASIAEKYFGSTGLVGL--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------QDKKVGALPYPSMFPLPFFPAFSQSMYPFPDR DLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPP----------------------- -----------------------------------VT----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -PATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------RVE KRKLTDPLEALKEKYLRPSPGFLFHPQMSAIENMAEKLESFSALK--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------PE--------- ------------------------------------------------------------------------ ----------------------------------------AS--ELLQS----------------------- ---------------------------------------------------------------------VPS MFNFRAPPNALPENLLRKGK------------ERYTC----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------RY--- ---------------------------CGKI----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------FPR---SANLTRH-------------LRTHTGEQPYRCKYCDRSFS------------------- ------------------------------------------------------------------------ -------ISSNLQRHVRNIH---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------NKEKPFKCHLCDRCFGQQTNLDRHLK--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------KH E-----------------------------------NGNMSGTATSS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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----------------------------------------DK------------EDA--------------- ------------------------------------------------------------------------ -------------------------------------------YF--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----TEIRNFIGNSNHGSQSPRNVEERMNGSHF-------KDEKALVT---SQNSDLLDDEEVEDEVLLDE ----------------------E-------------------------------DEDNDITGK--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------TGKEP------------------------------------------VT----------------- SNLHEGNPEDDYEETSALEM-------S--------------------------CKTSP------------- --------------VRYK------------------------------------------------------ ------------------------------------EEEYKSGLSALDHIRHFTDSLKMRKMEDNQY----- -----------------------SEAELSS-FS--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------TSHVP----EELKQPLHRKSKSQA--------------------------------YAMM LS---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------LSDKES---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------L------------------------------HSTSHSSSNV-----WHSMARA--- ------------------------A----------------AES--------------SA--I--------- ----------------QSISHV-------- >sp|Q5T1R4|ZEP3_HUMAN/1-2406 Transcription factor HIVEP3 OS=Homo sapiens OX=9606 GN=HIVEP3 PE=1 SV=1 MDPEQSV-KGTK-K-------------A--------EG--SPR-------K--RLTKGEAIQTSVSS----- ------------------SVPYPGSGTAATQESP-----------------AQEL-----LAPQP------- -------------------------FPG-PSS--VL----------R--EGSQ------------------- ----E------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------KTG--QQQKPPK--------------R----------- -------------------------------------------------------PPI-------------- -----------------EASVHIS--------Q--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------L-P------------- --------------QHPLTPAFMSPGKPEHLLEGSTWQLVDPMRP--------------------------- ------GPSGSFVAPG----L----------------------------------------H---------- ---PQSQLL--------------------------------------------------------------- ----------------------PSHAS--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------IIPPEDL--------------------- ------------------------------------------------------------------------ -------------------PG--------------------------------------------------- ----------------------------------------------------VPKVFVPRPSQ--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VSLKPTEEAHKKERKPQKPG-----KYICQYCSRPCAKPSVLQKHIRSHTGERPY PCGPCG----------------------F------------------------------------------- --------------------------S--------------------------------------------- -----------------------------------FKTKSNL------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------YKHRKSHAHRIK-AGLASGMGGEMYP HG-LEMERIPGEE-----FEEPTEGESTDSEEETSATSGHPAEL---------------------SPRPK-- ---------------------------------------------------------------------QPL LSSG------------------------LYS----------------------------------------- ---------------------------------------------------------------------SGS HS-SSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHK---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------PEDTH TIKQKLALRLSERKKV---------------------------------------------------IDEQA FLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQ----------RT-AMLTATSTQPL LPLSTEDKPSLVPL-SVPRTQVIEHITKLITINEAVVDTSEID----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------SVKPRR-- --------------------------------------S--------------------------------- ------------------------------------------------SLSRRSS------------ME--- ------------------------------------------------------------------------ ---------------SPKSS------------LYREPLSSHSEKTKPEQSL--------------------- -----------------------------------LSLQHPPSTAPPVPLLRSHSMPSAACTISTPHHPFRG SYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEV---------- -----------------EPKESELTKKTKKGLKTKGVIYECNICGA-------------RYKKRDNYEAHK- KYYCSELQIAKPISAGTHTSPEAEKSQI-------EHEPWSQM---MHYKLGTTLELTPLR----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----KRRKEKSLG----------------------------------DEEEPPAFESTKSQFGSPGPSDAAR NLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSG-SESGKERRTTSKEISVI------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------QHTSSFEKSDSLEQPSGLEGEDKPLAQFPSPPPAPHGR SAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRL AEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSR-------SASFERDDHGKAEAPSPSSDMRP--KPLGT HML--------------------------------------------------------------------- ------------------------------------TVPSHHPHAREMRR---------------------- ----------------------------------SASEQ--------------------------------- ------SPNVSHSAHMTETRSKSFDYGSLSLTG--------------------------------------- -----------------------PSAPAP------------------------------------------- ----------------------------------------------------------VA------------ -------------------------------------------PPARVAPP--------------------- ------------------------------------------------------------------------ ---------------------------------------------------------------ERRKCFLVR QASLSRPPESELEVAPKGRQESEEPQPSSSKPSAKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTE ALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSSLLSSPYSMPPLPPSLFQAPPL PLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQIKT SLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAP------------------------------------ ----------------------------------------------------TSAPPLALPACPDT------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------MVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSSATVALPKFEE--PPSKGTTVCGADVHEV GPGP-----------------------------------------SGLSEEQSRAFPTPYLRVPVTLPER-- -KGTSLSSE--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -SILSLEGSSSTAGGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKS HLGNQGQG---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---RRELEMLSSLSS----------------------------------------DPSDTKEIPPLPHPALS HGTAPGS----------------------------------------------------------------- -----------------------------------------EALKEYPQPS--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------GKPH----------------------------------------------------- ------------------------------RRGLT-------------------------PLSVKKEDSKEQ PDLPSLAPPSSLPLSETSSRPA-----KSQEGTDSKKVLQ------FPSLHTTT------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ----------------------------------------------NV------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -SWC------------------------------YLNY------------------IKPNHIQHADRRSSVY 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------SPEGQKDLA-----------R--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------VEKEEE------------------------------RRGEP EEDAPASQ---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------RGEPARI------------------------------------------------- ----------------------------------------------------KIFEGGYKSNEEYVYVRGRG RGKYVCEEC--------------------------------------------------------------- --------------G-------------------------------------------------IRCKKPSM LKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLFQDSEGREGSE AVEEHQFSDLEDSDSDSDLDEDEDEDEE-------------------------------------------- -------------------------------------------------------------------ESQDE ---L----SRPSSEAPPPG--PPHALRADSS----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------PILGP------------------Q---------------------- ------------------------------------------------------------------------ --------------------------------------PP--DAPASGTE---------------AT----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------RGSSVSEAER LTASSCSMS--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------SQS------------------ -----------MPGLPW-LGPAPLGSVE-------------------------------------------- ------------------------------------------------------------------------ ------------KD------------------------T--------------------------------- ------------------------------------------------------------------------ ----------------------------------------GSALSYKPVSPRRPWSPSKEAGSRPPLA---- ----RKHSLTKNDSSPQRCSPAR-----EPQAS--AP----------------------------------- -----------------------------------SPPGL--------------HVDPGRGMGALPCGS--- -----PRLQLSPLTL--CPLGRE------------------------------------------------- -------------LAPRAHVLSKLEGTTDPGLP----------RYSPTRRWSPGQAES-------------- ------------------------------------------------------------------------ ---PPRSAPPGKWA---------------------------------------------------------- -LA--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------GPGSPSAGEHGP--------------------------------------------- ---------------------GL------------------------------------------------- ---------GL-----------------------------------------DPRVL--------FP----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------P-------APLPHKLL------SRSPETC----------------------- ----ASP--------------WQKAES--------------------------------------------- ------------------------------------------------------------------------ ------RSPSCSPGP-AHPLSSRPFSALHDFHGHILARTEENIFSHLPLHSQHLTRAPCP---------LIP IGGIQMVQARPGAHPTLLPGPTAAWVS--------------------------------------------- -------------------------------------------------------------------GFSGG GS--DLTGAREAQERGRWSPTESSSASVSPVAKVSK----FTLSSELEGGDYPKERE-RTG--GGPGRPPDW TPHGTGAPAEPTPTHSPCTPPDTLPRPPQGRRAAQS--------------------------------WSPR LE---------SP-----RAPTN--PEPSA------------------------------------------ -------------------------------TP----PLD-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------RSSSVGCLAE-----A------SARFPAR- -------------------------------TR------------------N-----------LSGEPRT-- -------R------------Q-----------------D-SPKPS--------------------------- --G--------SGEP-----------------------------------R---AHP-----HQPEDRV--- ------------------------P----------------PN----------------------------- ---------------------A-------- >sp|Q96K83|ZN521_HUMAN/1-1311 Zinc finger protein 521 OS=Homo sapiens OX=9606 GN=ZNF521 PE=1 SV=1 MSRRKQA-KPRS-L-KD-P-------NC---------K---------------------------------- ------------------------------------------------------------------------ -----------------------------------L-------EDKT--EDG-------------------- EALDCKKRPEDGEELEDE------A----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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--------------------VHSC------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------DSC- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ LQVFESLSDITE--HKINQCQLTDGVD--V--EDDP------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------TC---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------SWPASSPSSKDQTSPS---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------H--GEGCD----------------------- ----------------------------------------------------------FGE--------EE- -----GGPGL------P------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------YPCQFCDKSFSRLSY LKHHEQSHSDKLPFKCTYCS-------------------R-LFK-HKRSRDRHIKLHTGDKKYHCSECDAAF SRSDHLKIHLKTHTSN-------------------------------------------------------- ------------------KPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSGSRMEDWKMKDTQKCSQCEE GFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEEL YSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPS SKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEA------- ---------------QDPG----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---LIVSAMPAIVYQCNFCSEVVNDLNTL------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------QEHIRCSHGFANPAAKDSNAFF----------------------CPHCYMGFLTDSSLEEHIRQ VHC--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------DLSG ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------SRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNI- ---PLALNY-IHNGKKSRALSPL------------------------------------------------- -------SPVA------------------------------------------------------------- ------------------------IEQTSLKMMQAVGGAPARPTGEY------------------------- -----ICNQCGA--------------------------KYTSLDSFQTHLKTHLDTVLPK---LTCPQCNK- -----------------------------------------------------------------EFPN--- ------------------------------------------------------------------------ QESLL-KH---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------VTIHF------MIT----------------- --STYYICESCDKQ---------------------------------------------------------- --------------------------------------------FTSVDDL--------------------- ----------------------QKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLA----------------- ------------------------------------------------------------------------ -------------------------------VKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVH KCIF--CGESFGTEVELQCHITTHSKKYNC--KF-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------CSKAF----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------HAI----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------ILLEKHLREKHCVFETKTPNCGTNGASEQV QKEEVELQTLLTNSQESHNSHDGSEEDVDTS------------------EPMYGCDICGAAYTME-TLLQNH Q------------LRDHNIRPGESAIVKKKAEL-----------------IKGN------------------ ----------YKCNVCSRTFFSENGLREHMQTHLGPVKHYMCPI---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------CGERFPSLLTLTEHKVTHSKS---LDTGNCR-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------IC----KM--PLQ-------------------SEEEFLEHCQM-HPDLRNSLTGFRC------- -VVCMQTVTSTL------------------------------------------------------------ -----------------------------ELKIHG-------------------------------TFHMQK TGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLD--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------INGLPYGL-------C----------------------------------------------- --------------------------------------AGC-----------------V------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------NLSKSASP----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------GINVPPGTNRPGLGQNENL--------------- ------------------------------------------------------------------------ ----------------SAIEGKGKVGGLKT------------------------------------------ ---------------------------------------R-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------CSS-CNVKFES-ES--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --ELQ-NHIQTIHRELV------------P----DS--------------------------------NSTQ LK---------TP-----QVSPM--P--RI----------SPSQSDEKKTYQCIK----------------- -----------------------------CQMV--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------FYNE---- -----------------------WDIQ-VHVANH-----------M-------------------------- ----------------------------------------IDEGLNHECKLC-----------SQT-FDSPA KLQCHLI------------------------EHSF------------EGMGGTFKCPVC--FTVFVQANK-- ---LQQHIFSAHGQ-EDK------------------------IYD-------------------CTQC---- --------------P----------------------------------QK-----F-----FFQ------- ----------------------------------------------------TELQNHT-----MTQHSS-- ------------------------------ >sp|Q96L73|NSD1_HUMAN/1-2696 Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1 MDQTCEL-PRR--N-C----------LL--P-----FS--NPV----------------------------- ----------NLD----------------------------------------------------------- ---------------------------A-PEDKDS--------------PFGN------------------- ----GQS---NFSEPLNG------CT---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------MQLSTVSGTSQNAYGQDS---- ------------------------------------------------------------------------ -----PSCYIPLRRLQDLA-------------SMINV---EY--------------LN-------------- -----------------GSADGS--------ES-----------FQ-DPE---------------------- KS---------------------------------------------------------------DS----- ------------------------------------------------------------------------ --------------------------------------------------------R-AQ------------ ---------------TPIVCT--------------------------------------------------- ------------------------------------------------------------------------ -------------SLSPG---------GPTALAMKQEPSCNNSPELQVKVTKTIK----------------- ------------------------NGFL----HFEN------------------------------------ ----------------------------FTCV--------------DDAD--VDS----------------- -----------------E-MDPE----------------------------------QPVTEDESIEEIFEE TQ-T---NA-----------TCNYETKSENGVKVAMGS-EQDS---TPESRH-------------------- -----GAV---------------------------------------------------------------- ----------------------------------------------KSPFL--------------------- ------------------------------------------------------------------------ -------------------PLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTN---------------- -------------------------------------------------------ITIEEQLNS-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------INLSFQDDPDS-------------STSTLGNMLEL------------------P GTSSSSTSQELPFC---------------------------------------------------------- --QPKK----------------------KSTP---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------LKYEVGDLIWAKFKRRPWWPCR-------- -----------ICSDPLINTHSKMKVSNRRPYRQYY------------------------------------ --------VEAFGDPSERAW----------------------------------------------VAGKAI V-MFE----GR------------------------------------------------------------- ------------------------HQFEELPVL---RRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVP KGSKNRKCIPGSIKLDSEEDMPFED----------------CTN---------------------DPESE-- ---------------------------------------------------------------------HDL LLNG------------------------CL------------------------------------------ ---------------------------------------------------KS-------------LAFDSE HS-A----------------------------------------------------------DEKEKPCAKS RARKSSDNPKRTSVKK-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------GHIQF--------------------------------EAHKDERRGKI PENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISK CSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDG---SSDLD-PI----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------EHSSESDNSVLEIPDAFD RTENMLSM---------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------------------QKN-----EKI KYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKS-------------------------------------- ---------------------------------------------------AEPG-TETSQVNLSDLKASTL ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------VHKPQSDFTNDALSPKFNLSSSISSENSLI- KGGAANQALLHSKSKQPKFRSIKCKHKENPV----------------------------------------- ------------------------------------------------------------MAEPPVINEECS LKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIE------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------TAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSS ASSQN--------------------------HIPIEPD--------------YKFSTLL-MMLKDMHDSKTK EQRLMTAQNLVSYRSPGRGDCST-----------------------NSPVGVSKVLVSGG------------ ------------------------------------------------------------------------ -----------------------STHNSEKKGDGTQNSA--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------NPSPSGGDSALSGELSASLPGLL------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------SDKRDLPASGKSRSDCVTRRNCGRSK PSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHL TSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTK PRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSS ASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQ--------- -------VHKVSSRCEEESLL---------------ARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEG PLAQSELGGG-------------------------------HAE---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ LPQLTLSVPVA------PEVSP-------------RPALESEELLVKTPGNYESKRQRKPTKKLLES--NDL DPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPR--------KRKRQRHAAAKMQ CKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGER-G----------------- ------------------------------------------GG---------------------------- -----------------------------------------A------------------------------ -----------------------------------ALK-----------------------EN--------- ------------------------------------------------------------------------ ----------------------------------------VC--QNCEK----------------------- ----------------------------------------------------------LGE--------LLL CEAQCCGAFH------LECL--G--LT-EMPRGKFICNECR-TG---------------------------- -----------------IHTC--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------F------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------VCKQSGEDVKRCLLPL--- ---------------------------CGKFYHEECVQKYPPTVMQ-------------------------- ------------------------------------------------------------------------ ----------------------------NKGF---------------------------------------- -----------------------------RCSL--------------------------------------- -----------------------------HICITCHAANPANVSASKGRLMRCVR----------------- ------------------------------------------------------------------------ -----------------------------------------------CPVAYHANDFCLAAGSKILASNSII CPNHFTPRRGCRNHEHVNVS--------------------------WCFV---------------------- ---------------------------CSEG----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------G------ ------------------------------S---LLCC---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------DSCPA----------------AF----------HRECLNI---------DIPEGNWYC -NDCKAG-KKPHYREIVWVKVGRY--RWWPAEICH------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------PR---------- ------------------------------------------------------------------------ --------------------------------------------------------------------AVPS ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------NI--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------DK-------------MRHDVGE-FPVLF-FG------ ------------------------------------------------------------------------ ------------------SND--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------YLWTHQ--A----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------R------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------VFPYM------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------EG--DVS---------SKDKMGKGVDGTY-----------K--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------KALQEA------------------------------AARFE ELKAQKELR--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------QLQE------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------DRKNDK-------------------------------------------- -------------------------------------------------------------------KPPPY -KHIKVNRPIGR------------------------------------------------------------ ------------------------------------------------------------------------ ---------------V-------------------------------------------------------- -----------------------------------------------------QIFTADLSEIPRCNCKA-- --------------------------TDENPCGIDS---ECINRMLLYEC---------------------- ------------------------------------------------------------------------ --------------------------------------HP--TVCPAGGR---------------------- ------------------------------------------------------------------------ -----------C--------QNQCFSKRQYPEVEIFRTL--------------------------------- ------------------------------------QRGWGLRTKTD---------------IKKGEF---- ---------------------------------------VNEYVGELIDEEECRARIRYAQEHDITNFYMLT LDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECL--------- -------GNGKTVCKCGAPNCSGFL----------------------------------------------- ----------------------------------------------------------------G------- ------------------------------------------------------VRPKNQP-IATEEKS--- ------------------------------KKFKKKQQGKRRTQG-EITKERED---ECFSCGDA------- -GQLVSCKKPGCPKVYHADCLNLTKRPAGKWE---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------CPWHQCDICGKEAASFCEMCPSS-------------------------------- ------FCKQHR------------------------------------------------------------ -------------EGMLFISKLDGRLSCTE------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------HDPCGPNPLEPGEIREYVPPPVPLPPGPSTH LAEQST------------------GMAAQA------PKMSDKPPADTNQMLSLS------------------ -----------KKALAGTCQRPLLPER--------PLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDR PPAVAGP------------------RPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRP ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------QSLEKTS--VPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPE-----------K VLSAVVQTL--------------------------------------------------------------- ------------------------------------------------------------------------ -------------V---------------------------------------------------------- -AK-------------------------------EKALRPV------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------DQNTQSKN RAALVMDLIDLTPRQKERAASPH-------------------------------QVTP-------QADEK-- ----MP------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------VLESS--------------------------------------------------------- --S--------------------------------------------------------------------- -----------------------------------W------PASK-------------------------- -----------------------------------------------------------GLGHMPRA----- -----------------------VEKGCVS-DP--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------LQTSGKAAAPSEDPWQAVKSL TQARLLSQPPA--------------------------KAF-------------------------------- -----LYEP--------------------------------------------------------------- ------------------------------------------------------------------------ -----TTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLP------- ------------------TEE-KKLVT-TEQ-----------SPWA-------------------------- ----------------------------------------LGKA------SS----RAGLWPI-VAGQTLA- -------------------------------QS--------------CWSAG---------S-TQTL----- -------AQTCWSLG----RG-----------------Q-DPKPE---------------Q--------NTL PAL--------NQAPSSHKCAE-----------------------------------------SE--QK--- ------------------------------------------------------------------------ ------------------------------ >sp|Q8TDI0|CHD5_HUMAN/1-1954 Chromodomain-helicase-DNA-binding protein 5 OS=Homo sapiens OX=9606 GN=CHD5 PE=1 SV=1 MRGPVGT-EEE-----------------------------LPR----LFAE--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -EMENED---EM---SE------------------------------EE----------------DGG---L EAFD-----D-----------F--------F--------------------------------------PV- -----------EP-VS--LPKKK-------KP-----KKLKENKCKG-KRK-------------KKE----- ------------------------------------------------------------------------ ----------------------------------G------------------------------------- -----------------------------------------SNDELSENEEDL---------------EE-- ------------------------------------------------------------------------ ------------------------------------------------------K----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------SESEGSD--YS--PNKKKK---------------------KKLKDKKEKKAKRKK KDEDEDDNDDGCLKEPKSSGQLMAEWGL-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------DDVDYLFSEEDYHTLTNY------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------KAFS QFLRPLIA---------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------------------KKN-----PKI PMS--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------KMMTVLG----AKWREFSANNP FKGSSAAAAAAA--VAAAV-ETV---T--ISPPL-------------------------------------- -------------------------------------------------------------AV--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------SPPQVP--Q PVPIRKAK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------TKEGKGPGVRKKIKG------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------S---KDG------------------------ ---------------------------------------------------KKKGKGKKTAGLKFRFGGISN ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------KRKKGSS-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------S-------EE-DEREESDFDSASIHSASV RSECSAALG-KKSKR---RRKKKR----I---------DDGDGY---------------------------- -----------------------------------------E------------------------------ -----------------------------------TDH-----------------------QD--------- ------------------------------------------------------------------------ ----------------------------------------YC--EVCQQ----------------------- ----------------------------------------------------------GGE--------IIL CD-TCPRAYH------LVCLDPE--LE-KAPEGKWSCPHCEKEG---------------------------- -----------------IQW---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------EPKDDDDEE----EE---- ---------------------------GG------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------CEEEEDDHME--------------------------FCRV---------------------- ---------------------------CKDG----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------GE---LLCC---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------DACPS----------------SY----------HLHCLN------PPLPEIPNGEWLC -PRCTCPPLKGKVQRILHWRWTEPP---APFMVGL------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------PGP---------- ------------------------------------------------------------------------ --------------------------------------------------------------------DVEP ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------SLPP----------------P--KPLEGI---------PEREFFVKW------ -----------------AGLSY-------------------------------------------------- --------------------------------------WHC------------------------------- ----------------SWVKELQLELYHTV-MYRNYQ-------------RKNDMDE-PPPFD-YG------ ------------------------------------------------------------------------ ------------------SGDEDGKSEKRKNKDPLYAK-------MEERFYR-------------------- ----------------YGIK-------------------P-EWMMIHRIL-NHSFDKKG------------- ---------------DVHY----------------------------------LIKWKDLPYDQCTWEIDDI DIPYYDNLKQAYWGHR--E----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------L------- ---------------MLGEDTRLPKRLLK------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------KGKKLRDDKQE---KPPDTPIVDPTV----KFDKQPW-------------- ---------------------------------------------------------------YIDSTGGTL HPYQLEGLNW-LRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLS------------ --------------------TIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRSGKKVFRM KKEVQIKFHVLLTSYELI------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --TIDQAILGSIEWACLVVDEAHRLKNNQ------------------------------------------- -------------------------------------------------------SKFFRVLNSYKIDYKLL LTGTPL-QN------------------------------N-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --LEELFH-----------LLNFLTPE--------------------------------------------- --R--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------FN--------------------------------NLEGFLEEFADISKEDQIKKLHDLLG ---------------------------------PHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFIL TRNFEALNSKGG------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------GNQ- ---VSLLNI-MMDLKKCCNHPYL------------------------------------------------- -------FPVA------------------------------------------------------------- ------------------------AVEA-----------PVLPNGSY------------------------- -----DGSSLVK--------------------------SSGKLMLLQKMLKKLRDEGHRV---LIFSQMTK- -----------------------------------------------------------------MLDL--- ------------------------------------------------------------------------ LEDF-LEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPH- -----------------------------------------NDIQAFSRAHRIGQ--------------NKK VMIYRFV----------------------TRAS--------------------------------------- -------------VEE-------------------------------------------------------- ---RITQVAKRKMMLTHLVVR--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------PGLGSKSGSMTKQELDDILKFGTEELFKDDV-E--GMMSQGQRPVTPIPDV QSSKGGNLAASAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQN---MNEYLSSFKVA QYVV--REEDGV--EEVEREIIKQEENVDP--DYW---------------------------------E--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------KLLRHH---------------------------YE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----QQQEDLARNLGKGKRIRKQVNYNDASQ---------------------------------------- ------EDQEWQD----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ E--LSDNQS--------------------------------------------------------------- --------------EYS--------------IGS-------------------------------------- ------------------------------------------------------------------------ --------------------EDEDEDFE-------------------------------------------- -------------------------------------------------------------------ERPEG QSG--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------RR---QSRRQ---------------------------- ----------------LKSDRD-------------------------------------------------- --------------------------------------KP--L-PPLLAR---------------------- ------------------------------------------------------------------------ -----------VGGNIEVLGFN-ARQRKAFLN----AIM--------------------------------- ------------------------------------RWGMPPQDAFNSHWLVRDLRGKSEKEFR-------- ------------------------------------------------------------------------ ------------AYVSLFMRHLCEPGADGAET---------------------------------------- ------------------------FADGVPRE---------------------------------------- -----------------------GLSRQH------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VLT---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------RI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------G V-----------------------------------MSLVRKKVQEFEHVNG-------------------- ------------------------------------------------------------------------ ----------------------KYSTPDLIP----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------EGPEG-KK----------------------------------SG EVISSDP------------------NTP-------------------------------------------- VPASPAHLLP-APLGLP----------DKMEAQLGYMDEKD----------------PG------AQKPRQP LE---------------------------------------------------------------------- --------VQ---AL---PAAL---------------------------------------------D---- ----RVESEDKHE----------------------------------------------------------S PASKERAREERPEETEKAPPS--------------------------------P------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----EQLPRE---------------------EVLPEKEKIL------------DKLELSLIHSRGDSSELR PDDTKAEEKEPIETQ--------------------------QN-GD---------------KEEDDEGKKED KKGKFK-------------FM--------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------FNIADGGFTELH---------------TLWQNEER AAVSSGKIYDI-------------------WHRR-----HDYWLLAGIV---T-------------HGYARW ----------------------Q-------------------------------DIQNDPRYM--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------ILNEP------------------------------------------FK----------------- SEVHKGNY---------LEM-------K--------------------------NKFLA------------- --------------RRFK-LLEQALVIEEQLRRAAYLNMTQDPNHP-------------------------- -----------------------------------------------------------AMALNARL----- -----------------------AEVECLA-ES--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --HQH-LSKESLAGNKP------------ANAVLHKVLNQLEELLSDMKADVTRL----------------- ---------------------------------------------------PSML----------------- -----------------------------SRIP--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------PVAARLQM S----------------------------------------------------------------------- --------------------------------------------------------E--------------- ------------------------------------------------------------------------ ------------------------RSILSRLTNRA---G-DPTIQ-------------------QGA-FG-- -----------SSQMYSNNFGP-NFRGPGP--GGI---VN-----Y-----N--QMPLG-PY---------- ------------------------------------------------------------------------ ----VTD----------------------I >sp|Q92793|CBP_HUMAN/1-2442 CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3 MAENLLD-G-PP-N-------------P---------K--RAK----------------------------- -----------LS----------------------------------------------------------- ---------------------------S-PGF--SA-------NDST--DFGS------------------- -LFDLEN---DL---PDE------LI--------PN-----------GG----------------ELG---L LNSG-------------------------------------------------------------------- ---NL------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------VP---DAAS---KHKQLSELL RGGSGSSINPGIG------------------N-VSASS------P--------------------------- --------------------------------VQQGL---GG--------------QA-------------- -----------------QGQPNSA--------N-----------MA-SLS---------------------- A----------------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------M-G------------- --------------KSPL----------------------------------------------S------- --------QGDS-----SAPS----------------------------------------L---------- ---PK------------------------------------------------------------------- ------------------------QAA--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------STSGPTP----------------------------- ------------------------------------------------------------------------ -----------------------------------------A----------ASQALNPQAQKQV------- -----GLATSSPATSQTGPGICMNA-NFNQTHPGLLNSNSG------------------------------- ---------------HSLINQASQG----------------------------------------------- ----------------------------------------------------------QAQVMNGSLGAAGR GRGAGMPYP------------------------------TPAMQGASSSV---------------------- ---------------------------------------------------------LAETLTQ-------- ------------------VSPQMTGHAGL-------------NTAQAGGMAKM------------------G ----------------------------ITGNTSPFG-------QPFSQ----------------------- -----AGGQPMGATGVNPQLASKQSMVNS------------------------------------------- --------------------------LPT------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ FP-TDIKNTS-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ VT-N---------------------------------VPNMSQMQTSVGIVPTQAIATGPTAD--------- -------PEKRKLIQQ-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------QLVLLL--------------------------------HAHKCQRRE-- ------------------------------------------------------------------------ -----------------------------------------------------QANGEVRACSLPHCRTMKN VLNH-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------MTHCQAGKACQVAHCASSRQIISHWKNCTRHDCP---------------- ------VCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYM- NQPQTQLQ---------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------------------PQVP------- --------------------------------------G--------------------------------- ------------------------------------------------QQPAQPQ-THQQMRTLNPLGNNPM NIPAGG--ITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQD LRSHLVHKLVQAIFPT-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------A SQVKEETDIAEQ-KS----------------------------------------EPMEVDEKK-------- -------PEVKVEVKEEEESSSNGTASQSTSPSQPRK-----------------------------KIFKPE ELRQALMPT--------------------------------LEAL--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ YRQDPESLPFR------QPVDP------------QLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVD DVWLMFNNAWLYNRKT-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------SR--------- ------------------------------------------------------------------------ ----------------------------------------VY--KFCSK----------------------- ----------------------------------------------------------LAEVFEQEIDPVMQ SLGYCCGRKYEFSPQTLCCY------------GKQLCTIPR-DA---------AYYSYQ------------- ---------------NRYHFCEKCFTEIQGENVTLGDDPS-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------QPQTTIS----------------------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------G------ ------------------------------H---IWAC---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------P-------------------------------------------------PSEGDDYI -FHC-------------------------------------------------------------------- -----------------------------------------H------------------------------ ------------------------------------------------------------PPDQKIPKPKRL QEWYKKMLDK-------------------------------------------------------------- --------------------------------------------------------------------AF-- ------------------------------------------------------------------------ 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--------AQ---PP---PAAVE--AARQIEREAQ------------------------------------- -----------------QQQHLY-----RVNIN--NS-MPPGRTGMGTPGSQMAPVSLNVPR-PNQVSGPVM PSMPP------GQW------------------QQAPLPQQ--------------Q---------PMPGL--- -----PRPVISMQAQAAVAGPRMPS---------------------------------VQ-----------P PRSISPSAL--------------------------------------------------------------- ------------------------------------------------------------------------ -------------Q---------------------------------------------------------- -DL-------------------------------LRTLKSPS------------SPQ--------------- ------------------------------------------------------------------------ -------------------------------------------QQ--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----QQVLNI-------------------LKSN-------PQLMAAFI---K-------------QRTAKY ----------------------V-------------------------------ANQPGMQ--------PQP GLQSQPGMQP-----QPGMHQQPSLQN--------------------------------------------- ---------------------LN------------------------------------------------- ---------AM-----------------------------------------QA--G--------VPRPGVP PQQ------QA------------------------------------------MG----------------- GLNPQGQA---------LNIMNPGHNP--------------------------------------------- ---------------------------------------------N--M----------------------- ----ASM--------------NPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQF----- -----------------------QQPQGPGGYPPAMQQQQRMQQ--------------------HLPLQGSS MGQMAAQMGQLGQMGQPGLGAD-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------ST----PNIQQALQQRILQQQQMKQQI--GSPGQPNPM SPQQHMLSGQPQASHLP------------GQQIATS--------------------------------LSNQ VR---------SP-----APVQS--PRPQS------------------------------------------ -------------------------------QP----PHS-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------SPSPR--------------------------- --I--------QPQPSPHHVSP-QTGSPHP--GLAVTMASSIDQGHLGNPE---QSA-----MLPQLNT--- ------------------------P----------------SRSALS-----------SE--L-SLVGDT-- ----TGDT------LEKFVEG--------L >sp|Q92794|KAT6A_HUMAN/1-2004 Histone acetyltransferase KAT6A OS=Homo sapiens OX=9606 GN=KAT6A PE=1 SV=2 MVKLANP-LYTEWILE----------AI--KKVKKQKQ--RPS----------------------------- ------------E----------------------------------------------------------- ---------------------------ERICNAVSS-------SHGL--DRKT------------------- -VL-E--------------------Q---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------LELSVKDGTILK---------- ------------------------------------------------------------------------ -----------------VSNKGLNSYKDPDNPGRIAL---PK--------------PR-------------- -----------------NH----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------GKL---DNKQNV-------------------- -----DWNKLIKR----------------------------------------------------------- ------------------------AVEGLAE----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ --------------------------------------------------------KGQKDVSALFGGSAAS GFHQQLRL---------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------------------AIK-----RAI G----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --HGRLLKDGPLYRLNTKATNVDGKESCESLSCLPPVSLLPHEKDKPVAEPIP-I----------------- ------------------------------------------CS---------------------------- -----------------------------------------F------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------TCSSC--------------------- ----------------------------RDQ----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------G------ --------------------------KNADN---MLFC---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------DSCDR----------------GF----------HMECCDPPLT------RMPKGMWIC -QICR-PRKKGR--KLLQKKAAQIKRRYT-NPIGR------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------P----------- ------------------------------------------------------------------------ -----------------------------------------------------------------------K ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------NR--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------LK-------------KQNTVSK-GPFSK-VRTGPGRG RKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSE QYRIRKRGNRKSSTSDWPTDNQDG------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------WD---- ---GKQENEERLFGSQ--E----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------I------- ---------------MTEKDMELFRDIQE------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------QA--LQKVGVT---GPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPK LYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQN---------------- ---------------------------------------------------LCL------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------LAKLF LDHKTL-YY------------------------------DVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQK YNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISI KKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSV VSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLP ANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQ DGKPDLPK-----------RRLSEGVE--------------------------------------------- --PWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKP FLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRR LSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRK PIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQA 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------VS--EEQ---------RQSEEEQQELEEP-----------E--- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------KDK------- -EETEL-------------------------D----------------------------------SEEEQP SHDTSV------------------------------VSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSEL DLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQ SVRSVSSPNVPALESGYTQISPEQGSLS-------------------------------------------- --------------------------APSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENP SSYDSTMGG--------------------------------------------------------------- SI-------C----GNSSSQSSCSYGGLSSSSSLTQSSC--------------------------------- ------------------------------------------------------------------------ -----------------------------VVTQQ-------------------------------------- -------------------------------------------MASM------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----GSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPP-QPQPAPQPP----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------P ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------P------------------------------------- -----------------QQQPQQQP---QPQPQ--QPPP-------PPPPQQQP------------------ 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HQQWTELNSTHLPDKPSSM--------------EQSTGESHGPLDSLRAP-FNERLAESTASAGPPSEPASK EVTCNECSASFASLQTYMEHHCPSARPP-PPL--RE-------ESAS--DTGE------------------- -EGDEES---DVENLAGE------IV---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------YQP---DGSAY--IVESLSQLT QGGGACGSGSGSGPLPSLFLNSLPGAGGKQGD-PSCAA------PV--------------Y----------- -----P-QIINTFHIASS--------------FGKWF---EG--------------PD-------------- -----------------QAFPNTS--------A-----------LA-GLS---------------------- PVL----HSFRVFDVRHKSNKDYLNSDGSA-----KSSCVSKDVPNNVDLSKFDGFVLYGKRKPI------- --------------LMCFLCKLSFGYVR--SFVTHAVHDHRMTLSEDERKILSNKNISA------------- 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MTQI------------------------QHNRHLGLGSLPSPAEAELYQYYLAQNMNL-------------- --PNLKMDS-------AASDAQFMMSGFQLDPAGPMAAMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFI QT-N---------------------------------DPSLK------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------LFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKL-C-- ------------------------------------------------------------------------ -----------------------------------------------------RYNTQLKANFQLHCKTDKH VQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESG VEGESCYYHCVLCNYSTKAKLNLIQHVRSMK---------------HQ----------RSESLRKLQRLQKG LPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADPEELAKDQEGGASSSQAEKELTDSPATSKRISFP GSSESPLSSKRPKTAEEIKPEQM------------------------------------------------- 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------------------------------------------------------------------------ -------------------------------------------------------------------EDHTI IVEEDKEEESDLE----------------------------------DKQSPTGSDS--------------- --GSVQEDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKRALQES ATG--------------------------------------------------------------------- -----------------------------QPEPTSSPDNKPFKCNTCNVAYS-QSSTLEIHMRSVLHQTKAR AAKLEAA----SGSSNGTGNSSSISLSSSTPSPVS------------------------------------- ------------------------------------------------------------------------ -----------------------------TSGSNTFTTSNPSSAGIAPSSNLLSQVPTESVGMPPLGNPIGA NIASPSEPKEANRKKLADMIASRQQQQQQQQQQQQQQQQQQQAQTLAQAQAQ-------------------- ---VQAHLQQELQQQAALIQSQLFNPTLLPHFPMTTETL----LQLQQQQ---------------------- ----------------------------------HLLFP--------------------------------- ------FYIPSAEFQLNPEVSLPVTSGALTLTG--------------------------------------- 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QTMPLQTL----PAQLPPQ-LGPVEPLPADLA--QLYQHQLNPTLLQQQNKRPRTRITDDQLRVLRQYFDIN NSPSEEQIKEMADKSGLPQKVIKH---------------------WFRNTLFKERQRNKDSPYNFS-----N PPIT-----------------------------------------SLEELKIDSRPPSPEPPKQEYWGSKRS SRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNL----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------PTRVIVVWFQNARQKARK NYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKDEDEEGQDDSQNEDSMDA MEILTPTSSSCSTPMPSQAYSAPAPSANNTASSAFLQLTAEAEELATFNSK--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------T EAGDEKPKLAEAPSA----------------------------------------QPNQTQEK--------- ------QGQPKPELQQQEQPE---------------Q-----------------------------KTNTPQ QKLPQLVSL--------------------------------PSL---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ PQPPPQAPPPQCPLPQSSPSPS------------QLSHLP------LKPLHTST------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------YQC -DQC------------------------------KLAFPSFEHWQEHQQLHFLSAQNQ-------------- ---------------------------------------FIH------------------------------ ------------------------------------------------------------P----------- ---------Q-------------------------------------------------------------- --------------------------------------------------------------------FLDR ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------PA--SSA---------TSPSTPTSTMNTL-----------K--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------RKLEEK------------------------------ASASP GENDSGTGGEEPQRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERK GQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSF SHLPPS-----------------SSDGQGVPLSPVSKT----MELSPRTLLSPSSIKVEGIEDFESPSMSSV NLNFDQTKLDNDD----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ CSSVNTAIT--------------------------------------------------------------- --------------DTTTGDEGNADNDSATGIATETKSSSAPNEGLTKAAMMAMSEYEDRLSSGLVSPAP-- ------------------------------------------------------------------------ ------------SFYSKEYDNEGTVDYS-------------------------------------------- -------------------------------------------------------------------ET--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------S-- --------------------------SLADP------------------C---------------------- ------------------------------------------------------------------------ --------------------------------------SP--SPGASGSA---------------GKSGDSG DRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSKLSMAKHFG INQTSYEGPKTE------------------------------------------------------------ -------------------------------------------------------------------C---- ------------------------------------------------------------------------ --------------------------------------------------------------TLCGIKYSAR LSVRDHIFS--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------QQHISKVKDTIGSQLDKEKEYFDPATVRQLMAQQELDRIK K-----------------------------------AN---------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----E------------------------------------------------------------------ ----VL------------------GLAAQQ------QGMFDNTPLQALN-LPTA------------------ -----------YPALQG-IPPVLLPGLNSPSLPGFT----------------------------------PS NTALTS------------------PKPNLMGLPS-------------------------------------T TV----------PS------------------------PGL----------------PT----------SGL PN---------------------------------------------------------------------- -KPSSASLSS---PT---PAQAT--MAMGPQQPPQQQQQQQ------------------------------- ----------------------------QPQVQ--QP----------------------------------- -----------------------------------PPPP--------------------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ----SSSTVTSSS----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------CSTS-------------------- ---------------------------------------------------G-----------VQPS--M-- -------PTDDYSEESDTDL--------------------SQKSD--------------------------- --G--------PAS-----------------------------------PV---EGP-----KDPS--C--- ------------------------P----------------KD---------------SG--L-TSVGTD-- ------------------TFRL-------- >sp|Q9BZ95|NSD3_HUMAN/1-1437 Histone-lysine N-methyltransferase NSD3 OS=Homo sapiens OX=9606 GN=NSD3 PE=1 SV=1 MDFSFSF-MQ----------------GI--MGNTI-QQ--PPQ----------------------------- ----------LID----------------------------------------------------------- ---------------------------S-A-NIRQ--------EDAF--DN--------------------- -----NS---DIAEDGGQ------TP---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------YEATLQQGFQYPATTEDLPPLT NG----------------------------------------------------------Y----------- -----P-SSISVYETQTK--------------YQSYN---QY--------------PN-------------- -----------------GSANGFG--------A-----------VR-NFS---------------------- PT---------------------------------------------------------------DY----- ------------------------------------------------------------------------ --------------------------------------------------------Y-HS------------ ---------------EIPNTR--------------------------------------------------- ------------------------------------------------------------------------ -------------PHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQ----------------- ------------------------NGRE----LFES------------------------------------ ----------------------------SLCG--------------DLL-----N----------------- -----------------EVQASE----------------------------------HTKSKHESRKEKRKK SN-K---HD-----------SSRSEERKSHKIPKLEPE-EQNR---PNERVD-------------------- -----TVSEKPRE----------------------------------------------------------- ------------------------EPVLKEEA-------------PVQPIL--------------------- ------------------------------------------------------------------------ -------------------SSVPTT----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------EVSTGVKFQVGDLVWSKVGTYPWWPCM-------- -----------VSSDPQLEVHTKIN---TRGAREYH------------------------------------ --------VQFFSNQPERAW----------------------------------------------VHEKRV R-EYK----GH------------------------------------------------------------- ------------------------KQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWD------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------IGIAHAEKALKMTREERIEQYTFIYIDKQPE EALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKT AAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLI ISTPNQRNEKPTQ----------------------------------SVSSP-------------------- ------------------------------------------------------------------------ ---EATSGSTGSVEKKQQRRSIRTRSESEKSTEV-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------VPKKKI--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------KKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVE--------MT SSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSS---LSRR-G----------------- ------------------------------------------TG---------------------------- -----------------------------------------M------------------------------ -----------------------------------SKK-----------------------DT--------- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------ESCPA----------------SF----------HPECLSI---------EMPEGCWNC -NDCKAG-KKLHYKQIVWVKLGNY--RWWPAEICN------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------PR---------- ------------------------------------------------------------------------ --------------------------------------------------------------------SVPL ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------NI--------------------------------------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------EG--DKS---------FAE-GQTSINKTF-----------K--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------KALEEA------------------------------AKRFQ ELKAQRESK--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------EALE------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------IEKNSR-------------------------------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------PMA-------------------------- ----------------------------------------PVS----------------------------- ------------------------------------------------------------------------ -------------------------------------------PE---------------Y-------WSKI KCK-------------WESQDH-----------------------------------------GEEVKE--- ------------------------------------------------------------------------ ------------------------------ >sp|Q14839|CHD4_HUMAN/1-1912 Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2 MASGLGS-PSPC-S-A------------GSE------EEDMDALLNNSLPP--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -PHPENE---ED---PE------------------------------ED----------------------- ---------------------L--------S--------------------------------------ET- -----------ET-PK--LKKKK-------KP-----KKPRDPKIPKSKRQ-------------KKERMLLC RQLGDSS----------------------------------------------------------------- ----------------------------------G------------------------------------- -----------------------------------------EGPEFVEEEEEV---------------AL-- ------------------------------------------------------------------------ ------------------------------------------------------R----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------SDSEGSD--YT--PGKKKK---------------------KKLGPKKEKKSKSKR KEEEEEEDDDDDSKEPKSSAQLLEDWGM-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------EDIDHVFSEEDYRTLTNY------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------KAFS QFVRPLIA---------------------------------------------------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------APPPPP--V EVPIRKAK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------TKEGKGPNARRKPKG------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------SPRVPDA------------------------ ----------------------------------------------------KKPKPKKVAPLKIKLGGFGS ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------KRKRSSS-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------E-------DD-DLDVESDFDDASINSYSV SDGSTSR-SSRSRKKLRTTKKKKKGEEEV---------TAVDGY---------------------------- -----------------------------------------E------------------------------ -----------------------------------TDH-----------------------QD--------- ------------------------------------------------------------------------ ----------------------------------------YC--EVCQQ----------------------- 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------------------------------------------------------------------------ --------------DTCPS----------------SY----------HIHCLN------PPLPEIPNGEWLC -PRCTCPALKGKVQKILIWKWGQPP---SPTPVPR------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------PP---------- ------------------------------------------------------------------------ --------------------------------------------------------------------DADP ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------NTPS----------------P--KPLEGR---------PERQFFVKW------ -----------------QGMSY-------------------------------------------------- --------------------------------------WHC------------------------------- ----------------SWVSELQLELHCQV-MFRNYQ-------------RKNDMDE-PPSGD-FG------ ------------------------------------------------------------------------ ------------------GDE--EKSRKRKNKDPKFAE-------MEERFYR-------------------- ----------------YGIK-------------------P-EWMMIHRIL-NHSVDKKG------------- ---------------HVHY----------------------------------LIKWRDLPYDQASWESEDV EIQDYDLFKQSYWNHR--E----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------L------- ---------------MRGEEGRPGKKL-K------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ --------------------------------------------------------------------GNQ- ---VSLLNV-VMDLKKCCNHPYL------------------------------------------------- -------FPVA------------------------------------------------------------- ------------------------AMEA-----------PKMPNGMY------------------------- -----DGSALIR--------------------------ASGKLLLLQKMLKNLKEGGHRV---LIFSQMTK- -----------------------------------------------------------------MLDL--- ------------------------------------------------------------------------ LEDF-LEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPH- -----------------------------------------NDIQAFSRAHRIGQ--------------NKK VMIYRFV----------------------TRAS--------------------------------------- -------------VEE-------------------------------------------------------- ---RITQVAKKKMMLTHLVVR--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------PGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGG--------------- ----------------------DNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQG---MNEYLSSFKVA QYVV--REEEMGEEEEVEREIIKQEESVDP--DYW---------------------------------E--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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--AP-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------RR---PSRKG---------------------------- ----------------LRNDKD-------------------------------------------------- --------------------------------------KP--L-PPLLAR---------------------- ------------------------------------------------------------------------ -----------VGGNIEVLGFN-ARQRKAFLN----AIM--------------------------------- ------------------------------------RYGMPPQDAFTTQWLVRDLRGKSEKEFK-------- ------------------------------------------------------------------------ ------------AYVSLFMRHLCEPGADGAET---------------------------------------- ------------------------FADGVPRE---------------------------------------- -----------------------GLSRQH------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VLT---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------RI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------G V-----------------------------------MSLIRKKVQEFEHVNG-------------------- ------------------------------------------------------------------------ ----------------------RWSMPELAE----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------VE-EN-KK----------------------------------MS QPGSPSP------------------KTP-------------------------------------------- TPSTPGDTQPNTPAPVPPAEDGIKIEENSLKEEESIEGEKE----------------VK------STAPETA IE---------------------------------------------------------------------- --------CT---QA---PAPA-------------------------------------------------- ------------------------------------------------------------------------ ---------------SEDEKVVVEPPEGEEKVEKAEVKERTEEPMETEPKGAAD------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------VEK------------VEEKSAIDLTPI------ ----------------------VVEDKEEKKEEEEKKEVMLQN-GE---------------TPKDLNDEKQK KNIKQR-------------FM--------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------FNIADGGFTELH---------------SLWQNEER AATVTKKTYEI-------------------WHRR-----HDYWLLAGII---N-------------HGYARW ----------------------Q-------------------------------DIQNDPRYA--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------ILNEP------------------------------------------FK----------------- GEMNRGNF---------LEI-------K--------------------------NKFLA------------- --------------RRFK-LLEQALVIEEQLRRAAYLNMSEDPSHP-------------------------- -----------------------------------------------------------SMALNTRF----- -----------------------AEVECLA-ES--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --HQH-LSKESMAGNKP------------ANAVLHKVLKQLEELLSDMKADVTRL----------------- ---------------------------------------------------PATI----------------- -----------------------------ARIP--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------PVAVRLQM S----------------------------------------------------------------------- --------------------------------------------------------E--------------- ------------------------------------------------------------------------ ------------------------RNILSRLANRA---P-EPTPQ---------------Q----VA-Q--- -----------------------QQ----------------------------------------------- ------------------------------------------------------------------------ ------------------------------ >sp|Q9Y4E5|ZN451_HUMAN/1-1061 E3 SUMO-protein ligase ZNF451 OS=Homo sapiens OX=9606 GN=ZNF451 PE=1 SV=2 MGDPGSE-IIES-V-P----------P----------A--GPE----------------------------- ------------------------------------------------------------------------ -------------------------------ASEST-------TDEN------------------------- -----ED---DI-----Q------FVSEGPLRPVL--------------------------------EYIDL 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------FREKIDFQHAHGLQ--ELEFI------------------------------------ ------------------------------------------------------------------------ --------------------------------RGHSDT-EAAR---LCVDQWLKMPGLKTGTINCGTKSSFR RGGHTWV----------------------------------------------------------------- ---------------------------------------------SGKPIL--------------------- -----------------------------------CPIMHC------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------NK------------------------------- -------------------------------------------EFDNGHLLLG------------------- -----------------------------------HLKRFDHSPCDPTITLHGPFFSSFACVVCYKKFVTQQ QYRDHLFDKEATDDGHNN------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------NLL----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------PQ--------IIQ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------GPVAVAEKSITQ-------VAEKFIL-------------------- ----------------RGYCPDCNQVFVDETSTQNHKQNSGHKV-------RVIN----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------SVEESVLLYCHSSEGN------------------------ ------------------------------------------------------------------------ --------------------------------------------------------KDPSSDLHLL------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------LDQSKFSSLKRTMSIKESSSLECIAIPKKKMNLKDKSHEGVACVQKEKSV VKTWFCECNQRFPSEDAVEK---------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------HVFSANTMGYKCV ----VC-GK--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ VCDDSGVIRLHMSRIHG---GAHLNNFLF------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------WCRTCKKEL----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---TRKDTIMAHVTEFHNGHRYFY------------------------------------------------ --------EMD------------------------------------------------------------- ------------------------EVEG-----------ETLPSSSTTLDNLTANKPSSAITVIDHSPANSS PRGKWQCRICEDMFDSQEYVKQHCMSLASHKFHRYSCAHCRKPFHKIETLYRHCQDEHDNEI---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------KIKYF------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------CGLCDLI---------------------------------FNVE EA-----------------------------------------------------FLSHYEEHH-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------SIDYVFVSEKTE-- ------------------------TSIKTEDDFPVIETSNQLT--------CGCRESYICKVNRKEDYSRCL QIMLDKGKLWF---------------------------RC--SLCSATAQ---------------------- ------------------------------------------------------------------------ -------------------NLT-DMNTHI--H---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------QVHKEKSDEEEQQ------ --YVIKCGT--CTKAFHD------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------P------------------------------------- --------ES-----------------------------AQQHFHRKHCFLQ-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------KPSVAHFGSEKSNLYKFTASASHTERKL KQAINYSKSLDMEKGVENDLSYQNIEEEIVELPDLDYLRTMTHIVFVDFDNWSNFFGHLPGHLNQGTFIWGF QGGNTNWKPPLNCKIYNYLNRIGCFFLHPRCS---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------KRKDAAD FAICMHAGRLDEQLPKQIPFT--------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------ILSGDQGFLELE---------------NQFKKTQR PAH--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------ILNP------------------------------------------HHLEGDMMCALLNSISDTT KECDSDDN---------MGA-------K--------------------------NTSIG------------- --------------EEFI-STED-VELEEAIR---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------RSLEEM-------- >sp|Q9UIG0|BAZ1B_HUMAN/1-1483 Tyrosine-protein kinase BAZ1B OS=Homo sapiens OX=9606 GN=BAZ1B PE=1 SV=2 MAPLLGRKPFPL-V-K--P----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------L---PG------------------------------E------------------------ ---------E-----------P--------L----------------------------------------- -----------FTIPH--TQEAF-------RT-----R-----------EEYEARLER------YSERIWTC KSTGSSQ----------------------------------------------------------------- ----------------------------------L------------------------------------- -----------------------------------------THKEAWEEEQEV---------------AELL KEE--------------------------------------------------------------------- --------------------------------FPAWY---EK------------LVLE-------------- -----------------MVHHNTA------------------------------------------------ ----------------------SLE----------------------------------------------- -----------------KLVDTAWLEIMTKYAVGEECDFE-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------VGKEKMLKVKIVK--------IHP--------- 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------------------------------------------------------------------------ --------R--------------------------------------------------------------- ---------------------------------------KLPTSLKKGERKW--------APPKFLPHKYDV KLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHN------------------------------------ --------ALRAGTGENAPW----------------------------------------------VVEDEL VKKYS----LP------------------------------------------------------------- ------------------------SKFSDF------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------LLDPYK-------------------------------------- ----------------------------------------------------------YMTLN-------PS TKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPN 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------IS--KTARLLS ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------LPEELRSLVQKRYELLEH KKRWASMSEEQRKEYLKKKREELKKKLKE------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------DNKDSAAFEDNEVQDEFLEK-------LET-SEF-------------------- ----------------FELT-------------------SEEKL-------QILTALCH------------- ---------------RIL-----------------------------------MTYSVQDHME--------- ---TRQQMSAELWKER--L----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------AV------ ----------------LKEENDKKRAEKQ------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------KRKEM---EAK---N-KENGKV----------------------------- ------------------------------------------------------------------------ --------------------------ENGLGKTDR------------------------------------- -----------------------------------KKEIVKFE--------------PQVDTEAEDMISAVK SRRLLAIQAK-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --KEREIQEREMKVKLERQAEEERIRKHK------------------------------------------- -------------------------------------------------------AAAEKAFQEGIAKAKLV MRRTPI-GT------------------------------DR------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --NHNRYW-----------LFSDEVPG--------------------------------------------- --L--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------FI---------------------------------EKGWVHDSIDY-RFNHHCKDHTVSG DEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPK----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------QGQNL---WFLCDSQK- -----------------------------------------------------------------ELDEL-- ------------------------------------------------------------------------ -LNCL-HPQGI------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------RESQ--------------------------------------- -------------LKE-------------------------------------------------------- ---RLEKRYQDIIHSIHLARK--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------PNLGLKSCD-GNQELLNFLRSDLIEV------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------AT---------------------------------------- ------------------------RLQKGGLG---------------------------------------- -----------------------YVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFMA------- ------------------------------------------------------PKQKRRK-LQSEDSAKTE EVDEEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGED------- -DKLILCDE--CNKAFHLFC---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------LR------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------P A--------------------------------------------LYEVPDG-------------------- ------------------------------------------------------------------------ ----------------------EWQCPACQPATAR----RNSRGRNYTEESASEDSEDDESDEEEEEEEEEE EEEDYE------------------------------------------------------------------ ----VA------------------GLRLRP------RKT--------------------------------- --------------IRG-KHSVIPPAARSGRRPGKK----------------------------------PH STRRSQP------------------K---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------APPVDD---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------AEVDELVLQTKRSSRRQSLELQK------- -------CEEI-------------------LHKIV--KYRFSWPFREPV---T------------------- ------------------------------------------------------RDEAEDYYD--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------VITHP------------------------------------------MD----------------- FQ----------------T----------------------------------------------------- --------------------------VQNKCSCGSY------------------------------------ ------------------------------------------------------------------------ -------------------------------RS--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------VQEFLTDMKQVFTNA----------------- ---------------------------------------------------EVYN----------------- -----------------------------CRGS--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------HVLSCMVK T----------------------------------------------------------------------- --------------------------------------------------------EQCLVA---------- ---------------------------------------------------------------LLHKHLP-- ----------GHP-----YVRRKRKKFPDRLAEDE---G-DSEPE-------------------AVG-Q--- -----------------------SR------------------------------G---------------- ------------------------------------------------------------------------ ------RR------QKK------------- >sp|Q9NRL2|BAZ1A_HUMAN/1-1556 Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens OX=9606 GN=BAZ1A PE=1 SV=2 MPLLHR-KPFVR-Q-K--P-------------------------------P--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -A----D---LR---PD------------------------------------------------------- ---------E-----------E--------V----------------------------------------- -----------FYCKV--TNEIF-------RH-----Y-----------DDFFERTIL------CNSLVWSC 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------ALEAKKKEKEDKEKKREE LKKIVEEERLKKKEEKERLKVEREKEREK------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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-----------------------------------EDFDTSIESKDTEQKELDQDMVTEDEDDPGSHKRGRR GKRGQNGFKE-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --FTRQEQINCVTREPLTADEEEALKQEH------------------------------------------- -------------------------------------------------------QRKEKELLEKIQSAIAC TNIFPL-GR------------------------------DR------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MYRRYW-----------IF-PSIPG--------------------------------------------- --L--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------FIEEDYSGLTEDMLLPRPSSFQNNVQSQDPQVSTKTGEPLMSESTS-NIDQGPRDHSVQL ---------------------------------PKPV----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------HKPNR---WCFYSSCE- -----------------------------------------------------------------QLDQLIE ALNSRGHRESALKETLLQEKSRICAQLARFSEEKFHFSDKPQPDSKPTYSRGRSSNAYDPSQMCAEKQLELR LRDFLLDI---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------ED---------------------------------------- ------------------------RIYQGTLGAIKVTDRHIWRSALESGRYELLSEENKENGIIKTVNEDVE EMEIDEQTKVIVKDRLLGIKTETPSTVSTNASTPQSVSSVVHYLAMALFQIEQGIERRFL------------ ------------------------------------------------------------------------ -KAPLDASDSGRSYKTVLDRWRESLLSSASLSQVFLHLSTLDRSVIWSKSILNARCKICRKKGDA------- 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---------------------------------------------------------------FFH------ ---------------------IQAQKLGLHVTPSNVDQV--STPP-------------------AAK-K--- -----------------------SR------------------------------I---------------- ------------------------------------------------------------------------ ------------------------------ >sp|Q13129|RLF_HUMAN/1-1914 Zinc finger protein Rlf OS=Homo sapiens OX=9606 GN=RLF PE=1 SV=2 MADGKGD-AAA--V-AG-A-------GA---------E--APA----------------------------- ------------------------------------------------------------------------ -----------------------------VAG---A-------GDGV--ETESMVRGHRPVSPAPGASGLRP CLWQLET------ELREQ------E----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VSSLNYC------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------PCEVWLPFLQSLQESHDALLEFGNNNLQI LVHVTKEGVWKNPVLLKILSQQPVETEEVNKLIAQEGPSFLQMRIKHLLKSNCIPQATALSKLCAESKEISN VSSFQQAYITCLCSMLPNEDAIKEIAKVDCKEVLDIICN-----------------------LESEGQDNTA FVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSLDTF------------------------------- -----------------------------------------L--ERCRQ----------------------- ----------------------------------------------------------FGV--------IA- -----KTQQH------LFCLIR-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------VIQTEA----------------------------------------------- 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------------------------------------------------------------------------ -------------SEDEEMK---------------------------ASVC--------------------- ----------------------------KT------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------IACLLP------EDLEVRRACQLT -EFLIEPSLDGF--NMLEELYLQP------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------DQKFDEE ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------NAPV----------------P--NSLRCELLLALKAHWPFDPEFWDW------ -----------------KTLK--------------------------------------------------- -------------------------------------RH-C------------------------------- ----------------H------------QLLGQEASDSDDDLSGYEMSINDTDVLE-SFLSD-YD------ ------------------------------------------------------------------------ ------------------EGKEDKQYRRRDLTDQHKEKRDKKPIGSSERYQRWLQYKF-------------- --------------FCLLCK-------------------R-ECI-EARIL-HHSKMHMEDGIYTCPVCIKKF KRKEMFVPHVMEHV---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------KM------- ---------------PPSRRDRSKKKLL-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------L---KGSQKGICPKSPSAIPEQ--------NHSL------------- ----------------------------------------------------------------NDQAKGES HEY-----------------------------------VTFSKLEDCHLQDRDLYPCPGTDCSRVFKQFKYL SVHLKAEHQNNDENAKHYLDM-----------------------------------------------KNRR EKCTYCRRH-FMSAFHLR------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --EHEQVHCGPQPYMCVSIDCYARFGSVN------------------------------------------- -------------------------------------------------------ELLNHKQKHDDLRYKCE LNGCNIVFS------------------------------DL------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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----------------------------------------------------CFDGTKFT---CGFDGCGST YKNARGMQKHLRKVHPYHFKPKKIKTKDLFPSLGNEHNQTTEKLDAEPKPCSDTNSDSPDEGLDHNI----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------HIKC------KRE----------------- --HQGYSSESSICASKRPCTEDTMLELLLRLKHLSLKNSITHGSFSGSLQGYPSSGAKSLQSVSSISDLNFQ NQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKV--------------------- ----------------------LQLTMFQHRYSPFQCHICQRSFTRKTHLRIHYK----------------- ------------------------------------------------------------------------ -------------------------------NK--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------HQIGSDRATHKLLDNEKCDHEGPCSVDRLKGDCSAELGGDPSSNSEKPHCHPKKDECSSETDL ESSCEETESKTSDISSP--------------IGS-------------------------------------- ------------------------------------------------------------------------ --------------------HREEQEGR-------------------------------------------- -------------------------------------------------------------------EGRG- --SR---RTVAKG----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------NLCYILNKYHKPFHCIHKTCNSSFTNLKGL IRHYRTVHQYNKEQLCLEKDKARTKRELVKC------------------KKIFACKYKECNKRFLCSKALAK HCSDSHNLDHIEEPKVLSEAGSAARFSCNQPQC-----------------PAVF------------------ ----------Y----------TFNKLKHHLME----QHNIEGEIHSDYEIHCDLNGCGQIFTHRSNYSQHVY ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------YRHKDYYDDLFR----------------SQKVANERL LRSEKVCQTADTQGHEHQTTRRSFNAKSKKCGLIKEKKAP-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------ISFKTRAE--ALH-------------------MCVEHSEHTQY------------PC------- -MV--QGCLSVV------------------------------------------------------------ -----------------------------KLESSI-------------------------------VRHYKR T-----------------------------------HQM--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------SSAYLEQQ-------M----------------------------------------------- --------------------------------------ENL-----------------VVCVKYGTKIKEE- ------------------------------------------------------------------------ -----------PPSEADPCIKKE--ENRSCESERT------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------EH----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -SH-------------------------------SPGDSSAPIQNTDCCHSSERDGG--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------QK--------------------------- -----GCIESSSVFDADTLLYRGTLKCNHSSKTTSLEQCNIVQPPPPCKIENSIPNP--------------- ------------------------------------------------------------------------ ----------------NGTESGTYFTSFQL------------------------------------------ ---------------------------------------PLPRI---------------------------- ------------------------------------------------------------------------ --------------------------------------------------KESET----------------- RQHSSGQE---------NTVKNPTHVPKENFRKHSQPRSFDLKTYKPMGFESSFLKFIQ------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ESEEKEDDF----------DDW-EPSEHLT-LS--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --NSS-QSSNDLTGNVV------------A----NN--------------------------------M--- --------------------VND--SEPEV----------DIPHSSSDSTIHENL----------------- -----------------------------TAIP--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------PLIV---- -----------------------AETT-TVPSLE-----------N-------------------------- ----------------------------------------LRVVLDK------------------------- ------------------------------------------------------------------------ -----------------A------------------------LTD-------------------CGEL---- 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