>sp|Q9HCE7|SMUF1_HUMAN/1-757 E3 ubiquitin-protein ligase SMURF1 OS=Homo sapiens OX=9606 GN=SMURF1 PE=1 SV=2 MSNPGTRR-N-------------------GSS---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------I--KIRLTVLCA---------------------------KNL -AKKDFFRLPDP------------------------------------------------------------ --FAK-----IVVDGS----------------------------------------------GQCHSTDT-- VKNTLDPKWNQH-YDLYVGKTD-SITISVWNH------------KKIHKKQGA--------G---------- ----------------------FLGCV------------------R-------------------------- ----------------------------------------------L------------------------- --------------LSNAISRLKDTGYQRL--DLCKLNPSDT-DAVRGQIVVS------------------- ------------------LQTRDRI----------------------------------G-TGGSVVDC--- ------------------------------------R-----------------------GLLENEGTVYE- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------DSGPGRPLSCFM------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------EE---------- ------------------------------------------------------------------------ ------------------------------PAPYTDSTGAAAGGGNCRFV---------------------- ----------ESPSQD------------------------------------------------QRLQAQRL ----------------R------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------NP------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ DVRGSLQ------------T--PQNR--P----HGHQSP--------------------------------- ------------------------------E-----------LPEGYEQRTT-------------------- -VQGQVY----FLH-----TQTGVST-WH------------------------------------------- ----------------------------------------------------------D------------- -------------------------------PRIPS-P---------------------SG----------- ------------------------------------------------------------------------ ----------------------------------------------------T--------------IPGGD AAFLYEFL-----LQG-------------------------------------------------------- ------HTS--------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------EP---RD-----LNSVN-CD-E---------------- ----LGP-LP------------------PGWE-----VR-S------------------------------- -------------TV-------------SGRIYFVD------------------------------------ -------------------------HNNR------------------------------------------- -----------TTQF------TDPRLHH-------------------------------------------- --------------------------------------IMN--HQCQLK----------------------- --------------------------------------------------E--PSQPLPLPSEG-SLE-DEE L-----------------PAQR---------------------YERDLVQKLKVLRHE-------------- ------LS---------LQ---------QPQAGHCRIE---------------------------------- ---------VSREEIFEESYRQI---MKM----RPKD-L------K-KRLMVKFR-----GEEGLDYGGVAR EWLYLLCHEMLNPY-------YGLFQYSTDNIY-----MLQINPDSS--I-NPDHLSYFHFVGRIMGLAVFH GH-------YINGGFTVPFYKQLLGKP--------------I-----QL-SDLESVDPELHKSLV-WILE-- NDIT---PV-LDHTFCVE---H-NAFGRI-LQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLAL QKGFNELIPQHLLK-PFDQKELELIIGGLD-KIDLNDWKSNTRLKH--CVADSNIVRWFWQAV-ETFDEERR ARLLQFVTGSTRVPLQGFKALQ--------------------GSTGAAGPRLFTIHLID-ANTDNLPKAHTC FNRIDIPPYESYEKLYEKLLTAVEE-TCGFAV------E >sp|Q05086|UBE3A_HUMAN/1-875 Ubiquitin-protein ligase E3A OS=Homo sapiens OX=9606 GN=UBE3A PE=1 SV=4 MEKLHQCY-W-------------------KSG-EP----------------------------------QSD -DI---E--A-------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------SRMKRAAA---------------------------KHL -IERYYHQLT-------------------------------------------------------------- -------------EG--------------------------------------------------------- ------------------------------------------------------------------------ --------------------CGNEACTNEFCASCPTFLRMDNNAAA-------------------------- ----------------------------------------------IK-ALELYKINAKLCDPHPSKKGASS AYLENSKGAPNNSCS-------------EI------------------------------------------ -------------------------------KM--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------NKKG---ARIDFKDV--------------------T------- ------------------------------------------------------------------------ -------------------------------------------------------------YLTE------- ----------------------------EKVYEIL------------------------------------- ------------------------------------------------------------------------ -----ELCRERE----------------------------------------------------DYSPLIRV IGRVFSSA---------------------------------------------------------------- --EALV------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------QSF-------RK---------------------------VK QHTKEELKSL-----------------------------------------------------QAKDEDKDE DEKEKAACS--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --AAAMEED---SEASSSRIGDSSQGDNNLQKLGP-DDVSVDIDAIRRVYTRLLSN-E--KIETAFLNALVY LSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLA--------------- -AQGK----------LIRLWSKYNADQIR----------------------------------------RMM ETFQQLIT---------------------------------------------------------------- -------------------------------YKVISN-EFNSRNL--------------------------- ---------------------------------V---------------------------NDDDAIVAASK CLKMV----YYANVVGGEVDTNHNE----------------------------EDD---------------- ----EEP-IP------------------ESSE-----LT-LQELLGEERRNKKGPRVDPLETELGVKTLDCR KPLIPFEEFINEPLNEVLEMDKDY------TFFKVE------------------------------------ -------------------------TENK------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------FS F-----------------MTCP---------------------FILNAVTKNLGLYYDNRIRMYSERRITVL YS----LV---------QGQQ---------LNPYLRLK---------------------------------- ---------VRRDHIIDDALVRLEMIAME----NPAD-L-------KKQLYVEFE-----GEQGVDEGGVSK EFFQLVVEEIFNPD-------IGMFTYDESTK------LFWFNPSS------FETEGQFTLIGIVLGLAIYN NC-------ILDVHFPMVVYRKLMGKK--------------G-----TF-RDLGDSHPVLYQSLK-DLLEYE GNVE---DD-MMITFQISQ--T-DLFGNP-MMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAF RRGFHMVTNESPLKYLFRPEEIELLICGSR-NLDFQALEETTEYDGG-YTRDSVLIREFWEIV-HSFTDEQK RLFLQFTTGTDRAPVGGLGKLK------------------------------MIIAKNG-PDTERLPTSHTC FNVLLLPEYSSKEKLKERLLKAITY-AKGFGML------ >sp|P46934|NEDD4_HUMAN/1-1319 E3 ubiquitin-protein ligase NEDD4 OS=Homo sapiens OX=9606 GN=NEDD4 PE=1 SV=4 MAQSLRLH---------------------FAA-RRSN------------------T----Y-PLSETS---- -----------G------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------DDL--DS-HVHMCF-------KRPTRISTSNVVQMKLTPRQTA- ---------LAPLIKENVQSQERSSVPSSENVNKKSSCLQISLQPTRYSGYLQSSNVLADSDDASFTCILKD GIYSS-----AVVDNELNAVNDGHLVSSPAICSGSLSNFSTSDNGSYSSNGSDFGSCASITSGGSYTNSV-- ISDSSSYTFPP------------------------------------------------------------- ----------------------------------------------SDDTFLGGNLPSDSTSNRSVPNRNTT PCEIFSRSTSTDPFVQDDLEHGLEIMKLPVSRNTKIPLKRYSSLVIF------------------------- ----------------------------------------------------PRSPSTTRPTSPTSLCTLLS KGSYQTSHQFIISPSEIAH-NEDGT----------------------------------S-AKGF---L--- ------------------------------------S-----------------------TAVNGLRLSKTI CTPGEVRDI--------RPLHRK--------------GSLQKKIVLSNNTPRQTVCEKS------------- ----------------------------------S------E-----------------------------G YSCVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNSDSEYIKLMHRTSACLPSSQ----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------NVDCQININGELERPHSQMNKNHGILRRSISLGGAYPNISCLSSLKHNCSKGGP SQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPR SHKSRV------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------KGY-------LR---------------------------LK ---------MTYL----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------PKTSGS EDDNAEQAEELEPGWVVLDQPD---------AACHL-----------------QQQQE-------------- ------------------------------PSPLPPGWEE------------------RQDIL--------- ------------------------GRTYYVNHESRRTQWKRPTPQDNLTDAENG---NIQLQAQRAFTTRRQ ISEETE--SVDNRESSENWEIIREDE---------------------------------------------- ---------------ATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQ AYTFEEQ------------P--TLPV-------LLPTSS--------------------------------- ------------------------------G-----------LPPGWEEKQD-------------------- -ERGRSY----YVD-----HNSRTTT-WT------------------------------------------- ----------------------------------------------------------K------------- -------------------------------PTVQA-T---------------------VE----------- -----------------------------------------------------------TSQ---------- -------------------L-TS--S-----------------------------------------QSSAG PQSQASTSDSGQQV---------------------------------------------------------- -------T---QPS------------EIEQGFLPK-----------G------------------------- --------------------------------W-----------------------EVRHA-PNG------- ---RP----FFIDHN---------TKTTTWEDPRLK---IPAHLRGKTSLDTSN-D---------------- ----LGP-LP------------------PGWE-----ER-T------------------------------- -------------HT-------------DGRIFYIN------------------------------------ -------------------------HNIK------------------------------------------- -----------RTQW------EDPRLENV------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------------------AIT G-----------------PAVP---------------------YSRDYKRKYEFFRRK-------------- ------LK---------KQ---------NDIPNKFEMK---------------------------------- ---------LRRATVLEDSYRRI---MGV----KRADFL------K-ARLWIEFD-----GEKGLDYGGVAR EWFFLISKEMFNPY-------YGLFEYSATDNY-----TLQINPNSG--LCNEDHLSYFKFIGRVAGMAVYH GK-------LLDGFFIRPFYKMMLHKP--------------I-----TL-HDMESVDSEYYNSLR-WILE-- NDPT---E--LDLRFIID---E-ELFGQT-HQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAF KEGFFELIPQDLIK-IFDENELELLMCGLG-DVDVNDWREHTKYKNG-YSANHQVIQWFWKAV-LMMDSEKR IRLLQFVTGTSRVPMNGFAELY--------------------GSN---GPQSFTVEQWG--TPEKLPRAHTC FNRLDLPPYESFEELWDKLQMAIEN-TQGFDGV-----D >sp|Q76N89|HECW1_HUMAN/1-1606 E3 ubiquitin-protein ligase HECW1 OS=Homo sapiens OX=9606 GN=HECW1 PE=1 SV=3 MLLHLCSV-KNLYQNRFLGLAAMASPSRNSQS-RRRC------------------KEPLRY-SYNPDQFHNM DLRG--GPHD-GVTIPRSTSDTDLV----TSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYL IDE----VLSENFLDY--KNRGVNGSH---------RGQIIWKIDASSYFVEPETKICFKYYHGVSGALRAT TPSVTVKNSAAPIFKSIGADETVQG-QGSRRLISFSLSDFQA---------------------------MGL --KKGMFFNPDP------------------------------------------------------------ --YLK-----ISIQPGKHS---------------------------------IFPALPH--HGQERRSKI-- IGNTVNPIWQAEQFSFVSLPTD-VLEIEVKDK------------FAKSRPIIK--------R---------- ----------------------FLGKL------------------S-------------------------- ----------------------------------------------M------------------------- --------------PVQRLLERHAIGDRVVSYTLGRRLP--T-DHVSGQLQFR------------------- ------------------FEITSSIH----PDDEEISLSTEP----------------------ESAQIQDS PMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPG--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------NQSIEL -SRPAEEAAVITEAGDQGMVSVGPEGAGELLAQV-Q--------------------KDIQP----------- -----------------APSAE-------ELAEQLD--------LGEEASALLLEDGEAPASTKEEPLEEEA TTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVSELETVI----------------- -----ASACGDP----------------------------------------------------ET------ ----------------------------------------------------------------------PR THYIRIHTLLHSMPSAQGGS-----------------------------------AAEEEDGAEEESTLKDS SE----------KDGLSEVDT--------------------------------------------------- --------VAADPSALEEDREEPEGATPGTAHPG-------HSGG----------------------HFPSL ---------ANGAAQDGDT------HPS------------------------------------------TG ----------------SESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGN RFAS-------HTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSP----------EL-------- ---------------------------------------------------------DPE-----------S TNGAGPWQDELAAPSGH--------------------------------------------VE--------- ------------------------RSPEGL----------------------ES---PV--AGPS------- ------------------------------------------------------------------------ ----------------------------------------------------------------NRREGECP I-LHN------------SQPVSQLPSLRPEHHHYPTIDE--------------------------------- ------------------------------P-----------LPPNWEARID-------------------- -SHGRVF----YVD-----HVNRTTT-WQ------------------------------------------- ----------------------------------------------------------R------------- -------------------------------PTAAA-T---------------------PD----------- -----------------------------------------------------------GMR---------- -------------------R-----S----------------------------------------GSIQQM EQLNRRYQ-----NIQR------------------------TIATERSEE---------------------- ----DSGS---QSCEQAP-----------AGGGGG-----------GGSDSEAESSQSSLDLRREGSLSPV- NSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQH-NRD------- ---LV----NFINM------------------------------------F-AD-T---------------- ----RLE-LP------------------RGWE-----IK-T------------------------------- -------------DQ-------------QGKSFFVD------------------------------------ -------------------------HNSR------------------------------------------- -----------ATTF------IDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHS LVAAIRSQHQHESLPLAYNDKIVA--------FLRQPNIFE--MLQERQPSLARNHTLREKIHYIRTEGN-- -------HGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSS---PQNSPG-LQR-ASA R-----------------APSP---------------------YRRDFEAKLRNFYRK-------------- ------LE---------AK-GF------GQGPGKIKLI---------------------------------- ---------IRRDHLLEGTFNQV---MAY----SRKE-L------QRNKLYVTFV-----GEEGLDYSGPSR EFFFLLSQELFNPY-------YGLFEYSANDTY-----TVQISPMSA--F-VENHLEWFRFSGRILGLALIH QY-------LLDAFFTRPFYKALLRLP--------------C-----DL-SDLEYLDEEFHQSLQ-WMKD-- NNIT---DI-LDLTFTVN---E-EVFGQV-TERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEAL VRGFYEVVDSRLVS-VFDARELELVIAGTA-EIDLNDWRNNTEYRGG-YHDGHLVIRWFWAAV-ERFNNEQR LRLLQFVTGTSSVPYEGFAALR--------------------GSN---GLRRFCIEKWG--KITSLPRAHTC FNRLDLPPYPSYSMLYEKLLTAVEE-TSTFGL------E >sp|Q9HAU4|SMUF2_HUMAN/1-748 E3 ubiquitin-protein ligase SMURF2 OS=Homo sapiens OX=9606 GN=SMURF2 PE=1 SV=1 MSNPGGRR-N-------------------GP----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------V--KLRLTVLCA---------------------------KNL -VKKDFFRLPDP------------------------------------------------------------ --FAK-----VVVDGS----------------------------------------------GQCHSTDT-- VKNTLDPKWNQH-YDLYIGKSD-SVTISVWNH------------KKIHKKQGA--------G---------- ----------------------FLGCV------------------R-------------------------- ----------------------------------------------L------------------------- --------------LSNAINRLKDTGYQRL--DLCKLGPNDN-DTVRGQIVVS------------------- ------------------LQSRDRI----------------------------------G-TGGQVVDC--- ------------------------------------S-----------------------R----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------LFDN--------------------------------- ------------------------------D-----------LPDGWEERRT-------------------- -ASGRIQ----YLN-----HITRTTQ-WE------------------------------------------- ----------------------------------------------------------R------------- -------------------------------PTRPA-S---------------------EY----------- ---------------------------------------SSPGRPLSCFVDENTPISGTNGA---------- -------------------T-CG--Q--------------SSDPRLAE---RR--------------VRSQR HRN--------------------------------------------------------------------- --------YMSRTHLHT------------PPDLPE-----------G------------------------- --------------------------------Y-----------------------EQRTT-QQG------- ---QV----YFLHTQ---------TGVSTWHDPRVP---RD-----LSNIN-CE-E---------------- ----LGP-LP------------------PGWE-----IR-N------------------------------- -------------TA-------------TGRVYFVD------------------------------------ -------------------------HNNR------------------------------------------- -----------TTQF------TDPRLSANL------------------------------------------ ------------------------------------HLVLN--RQNQLK----------------------- --------------------------------------------------DQQQQQVVSL---C-PDD-TEC L-----------------TVPR---------------------YKRDLVQKLKILRQE-------------- ------LS---------QQ---------QPQAGHCRIE---------------------------------- ---------VSREEIFEESYRQV---MKM----RPKD-L------W-KRLMIKFR-----GEEGLDYGGVAR EWLYLLSHEMLNPY-------YGLFQYSRDDIY-----TLQINPDSA--V-NPEHLSYFHFVGRIMGMAVFH GH-------YIDGGFTLPFYKQLLGKS--------------I-----TL-DDMELVDPDLHNSLV-WILE-- NDIT---GV-LDHTFCVE---H-NAYGEI-IQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLAL QKGFNEVIPQHLLK-TFDEKELELIICGLG-KIDVNDWKVNTRLKH--CTPDSNIVKWFWKAV-EFFDEERR ARLLQFVTGSSRVPLQGFKALQ--------------------GAA---GPRLFTIHQID-ACTNNLPKAHTC FNRIDIPPYESYEKLYEKLLTAIEE-TCGFAV------E >sp|Q15386|UBE3C_HUMAN/1-1083 Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3 MFSFEGDF-KTRPK-----------VSLGGAS-RKEEKASLL----HRTQEERRKREEERRRLKNAIIIQSF -IRGYRDRKQ-QYSIQRSAFDRCAT----LSQSGGAFPIANGPNLTLLVRQLLFFYKQNEDSKRLIWLYQNL IK------HSSLFV------KQLDGSE---------RLTCLFQIKRLMSLC--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---CR-----LLQNCNDDS---------------------------------LNVALPM--RMLEVFS---- SENTYLPVLQDASYV-VSVIEQ-ILHYMIHN------------GYYRSL----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------YL-L--------------INSKLP--SSIEY---------------------S---- ------------------------------------DLSRVP-IAKI------------L-L---------- ------------------------------------------------------------------------ --------------------------------------------------------------ENVLKPLHFT YNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFIIP---ALAD-----------------------------A QTV-----------------------------------------------FPYEPFLNALLL---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------IESRCS----------------- -----RKSGGAP----------------------------------------------------WLFYFVLT VGENYLGALSEEGL---------------------------------------------------------- LVYL---------------RV---------------LQTFLSQLPVSPASASCH--DS---------ASDSE EESEEADKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMVQHRMMVP KVRLLY--S--------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------LAFNARF--------- --LR-------HL----WFLISSMSTRMIT-----------------------------------------G SM-----------------VPL------------------------------------------------LQ ----------------------------VISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPI EVVGQRQSSMMPFTLEELIMLSRC------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------LRDACLG-----IIK-LA------------------------------------------- ----------------------------------------------------------Y------------- -------------------------------PET-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------KPE VREEYITAFQSIGVTTSSEMQ-----------------------QCIQMEQKRWIQLFKVITNLVKMLKSRD TRRNFCPPNHWLSEQ------EDIKA---------------------------------------------- -----------------------DKVTQLYVPASRHVWRFR--RM-----------------------GR-- -------IGPLQSTLDVGL----------------------------------ES---PPLSVS-EERQLAV L-----------------TELP---------------------FVVPFEERVKIFQRL-------------- ------IYAD-----KQEVQGD------GPFLDGINVT---------------------------------- ---------IRRNYIYEDAYDKL---SPE----NEPD-L------K-KRIRVHLLNAHGLDEAGIDGGGIFR EFLNELLKSGFNPN-------QGFFKTTN-EG------LLYPNPAAQMLV-GDSFARHYYFLGRMLGKALYE NM-------LVELPFAGFFLSKLLGTS--------------AD---VDI-HHLASLDPEVYKNLL-FLKSYE DDVE---E--LGLNFTVV---N-NDLGEA-QVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAF RQGLANVVSLEWLR-MFDQQEIQVLISGAQVPISLEDLKSFTNYSGG-YSADHPVIKVFWRVV-EGFTDEEK RKLLKFVTSCSRPPLLGFKELYPA----------------------------FCIHNGG-SDLERLPTASTC MNLLKLPEFYDETLLRSKLLYAIEC-AAGFEL------S >sp|O00308|WWP2_HUMAN/1-870 NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Homo sapiens OX=9606 GN=WWP2 PE=1 SV=2 MASASSSR-A-------------------GVA-LPFE----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------KS--QLTLKVVSA---------------------------KPK -VHNRQPR-INS------------------------------------------------------------ --YVE-----VAVDGLP---------------------------------------------SETKKTGK-- RIGSSELLWNEI-IILNVTAQS-HLDLKVWSC------------HTLR-N-----------E---------- ----------------------LLGTA------------------S-------------------------- ----------------------------------------------V------------------------- --------------NLSNVLKNNGG---------------KM-ENMQLTLNLQ------------------- ------------------TENKGSV----------------------------------V-SGGE---L--- ------------------------------------T-----------------------IFLDGPTVDLGN VPNG------------SA----------------------------------LTDGSQL------------- ----------------------------------P------S-----------------------------R DSS-----------------------------------------------GTAVAP---------------- -------------------------------------------------ENRHQPPST-------------- -----------------------------------NCF--------GG------------------------ -------RSRTHRHSGA------------------------------------------------------- -----------SARTTP------------------------------------------------------- ------------------------------------------------------------------------ -------------------A-----------------------------------TGEQSPGA--------- ------------------------------------------------------------------------ --------------------------RSRHRQPV-------KNSG----------------------H-SGL ---------ANGTVNDEPTTATDPEEPSVVGVTSPPAAPL-----------------SVTPNPNTTSLPAPA ----------------T-----P------------------------------------------------- ---------------------------------------------------A----------EGEEPSTSGT QQ-----------------LPA---------AA----------------Q-------A-------------- ------------------------------PDALPAGWEQ------------------RELPN--------- ------------------------GRVYYVDHNTKTTTWERP------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------LPPGWEKRTD-------------------- -PRGRFY----YVD-----HNTRTTT-WQ------------------------------------------- ----------------------------------------------------------R------------- -------------------------------PTAEY-V---------------------RN----------- -----------------------------------------------------------YEQ---------- -------------------W-QSQRN----------------------------------------QLQGAM QHFSQRFL-----YQSS------------------------------------------------------- -------S---ASTDHDP-----------LGPLPP-----------G------------------------- --------------------------------W-----------------------EKRQD--NG------- ---RV----YYVNHN---------TRTTQWEDPRTQ---GM------------I-Q---------------- ----EPA-LP------------------PGWE-----MK-Y------------------------------- -------------TS-------------EGVRYFVD------------------------------------ -------------------------HNTR------------------------------------------- -----------TTTF------KDPRPGFES------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------G-TKQ G-----------------SPGA---------------------YDRSFRWKYHQFRFL-------------- ------C----------HS---------NALPSHVKIS---------------------------------- ---------VSRQTLFEDSFQQI---MNM----KPYD-L------R-RRLYIIMR-----GEEGLDYGGIAR EWFFLLSHEVLNPM-------YCLFEYAGKNNY-----CLQINPASS--I-NPDHLTYFRFIGRFIAMALYH GK-------FIDTGFTLPFYKRMLNKR--------------P-----TL-KDLESIDPEFYNSIV-WIKE-- NNLE---ECGLELYFIQD---M-EILGKV-TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAF LDGFNEVAPLEWLR-YFDEKELELMLCGMQ-EIDMSDWQKSTIYRH--YTKNSKQIQWFWQVV-KEMDNEKR IRLLQFVTGTCRLPVGGFAELI--------------------GSN---GPQKFCIDKVG--KETWLPRSHTC FNRLDLPPYKSYEQLREKLLYAIEE-TEGFGQ------E >sp|Q5T447|HECD3_HUMAN/1-861 E3 ubiquitin-protein ligase HECTD3 OS=Homo sapiens OX=9606 GN=HECTD3 PE=1 SV=1 MAGPGPGA-V-------------------LESP-RQLLGRVR----------FLA-EAARS-------LR-A -GR---PLPA-ALA---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------FVP------------------------------------------------------------- --REVLYKLYKD-PAG----PS-RVLLPVWEA------------EGLGLRVGAAGPAPGTGSGPLRA--ARD S-------------------------I------------------E-------------------------- ----------------------------------------------LRRGACV------------------R TTGEELC-------N-------------GH--GLWVKLT--------------------------------- -------------------------K----EQLAE-HLG--------------------------------- --------------------------------------------------------------DCGLQEGW-- -------------------------------------------------------------------LLVCR -------------------------PAEGGARLVP--IDTPNHLQRQQQLFGVDYRPVLRWEQVVD------ ------------------------------------------------------------------------ -----------------------LTYSHRLGSR--------------------PQPAEAYA----------- -----------------EAV-Q-------------------------------------------------- ------------------------------------------------RLL--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------Y------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------VPPTWTYECD-------------------- -EDLIHF----LYD-----HLGKEDE-NLGSVKQYVESI------DVSSYTEEFNVSCLTDSNADT------ ------------------------------------YWESDGSQCQHW---------VR------------- ------------------------------------------------------------------------ ----------------LTMK--------------------------------KGTIV--------------- -KKLLLTVDTTDDNFMPKRV--------VVYGGEGDNLKKL---SDVSIDETLI---------------GDV CVLEDMTV---------------------------------------------------------------- -------------------------------HLP-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------IIEIRIVECRDDGIDVRLRGVK-----IK-S------------------------------- -------------SR--------Q-----RELGLNA------------------------------------ -------------------------DLFQ------------------------------------------- -----------PTSL------V-------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------------------R-- --------------------YPRLEGTDPEVLYRRAVLLQRFIKILDSVLHHLVPAWDHTLGTFSEI----- ---------------------K------Q-VKQFLLLSRQRPGLVAQCLRDSESSKPSFMPRLYINRRLAME HRACPSRDPACKNAVFTQVYEGL---KPSDKYEKPLD-YRWPMRYD-QWWECKFI-----AEGIIDQGGGFR DSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPS-----CRD-FAKYEWIGQLMGAALRG KE-------FLVLALPGFVWKQLSGEE--------------V-----SWSKDFPAVDSVLVKLLE-VMEG-- MDKETFE-----FKFGKELTFT-TVLSDQ-QVVELIPGGAGIVVGYGDRSRFIQLVQKARLEES-KEQVAAM QAGLLKVVPQAVLD-LLTWQELEKKVCGDP-EVTVDALRKLTRFED--FEPSDSRVQYFWEAL-NNFTNEDR SRFLRFVTGRSRLPARIYIY----------------------------------PDKLGYETTDALPESSTC SSTLFLPHYASAKVCEEKLRYAAYN-CVAIDTDMSPWEE >sp|Q8IYU2|HACE1_HUMAN/1-909 E3 ubiquitin-protein ligase HACE1 OS=Homo sapiens OX=9606 GN=HACE1 PE=1 SV=2 MERAMEQL-N-------------------RLT-RSLR--------------------RART-VELPEDNET- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------AV------------------------------------------------------------ ------------------------------------------------------------------------ --YTLMPMVMAD--------QH-RSVSELLSN------------SKFDVN-----------Y---------- ----------------------AFGRV------------------K-------------------------- ----------------------------------------------R------------------------- --------------SLLHIA-ANCG---------------SV-ECLVLLLK--------------------- ----------------------KGAN----PNYQ--DISGCTPLHL-------------AARNGQ------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------KKCMS--------------------KL-----L EY-------------------------------------------------------SADVNICNN------ ----EGLTAI---------HWLAVNGRTELLHD--------------------LVQH-VSD----------- -----------------VDVED-------------------------------------------------- ------------------------------------------------AMGQTAL----------------- -----HVACQNG----------------------------------------------------HKT----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------TVQCLLDSG ADINRPNVSGATPLYFACSH---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------GQRDTAQILLLRGAKYLP------------------DKNGV--------- ------------------------TP---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------LDLCVQGGYGETCEVLIQYHPRLFQTIIQMTQNE DLRENMLRQVLEHLSQQSESQYLKILTSLAEVATTNGHKLLSLSSNYDAQMK-------------------- -SLLRIVRMFCHVF-----RIG-------------------------------------------------- ------------------------------------------------------------------------ -------------------------------PSS-P-S---------------------NG----------- -----------------------------------------------------------IDMGYNGNKTPRS QVFKP----------LELLWHSLDEW----------------------------------------LVLIAT ELMK------------NKRDSTEITSILLKQKGQDQDAASIP------------------------------ --------------PFEP---P-------GPGSYE-----------NLSTGTRESKPDALAGRQEA------ ------------------------------------------------------------------------ ------------S------------------------------------AD-CQ-DVISMTANRLSAVIQAF YMCCSCQ-MP------------------PGMTSPRFIEF-V------------------------------- -----------CKHD-------------EVLKCFVN------------------------------------ -------------------------RNPK------------------------------------------- -----------IIFDHFHFLLECPELMSR------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ F-----------------MHII---------------------KAQPFKDRCEWFYEH-------------- ------LH---------SG-QPDSDMVHRPVNENDILL---------------------------------- ---------VHRDSIFRSSCEVV---SKA----NCAK-L------K-QGIAVRFH-----GEEGMGQ-GVVR EWFDILSNEIVNPD-------YALFTQSADG-T-----TFQPNSNSY--V-NPDHLNYFRFAGQILGLALNH RQ-------LVNIYFTRSFYKHILGIP--------------V-----NY-QDVASIDPEYAKNLQ-WILD-- NDIS---DLGLELTFSVE---T-DVFGAM-EEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAF LQGFHMFIPPSLIQ-LFDEYELELLLSGMP-EIDVSDWIKNTEYTSG-YEREDPVIQWFWEVV-EDITQEER VLLLQFVTGSSRVPHGGFANIM--------------------GGS---GLQNFTIAAVP-YTPNLLPTSSTC INMLKLPEYPSKEILKDRLLVALHCGSYGYTM------A >sp|Q96J02|ITCH_HUMAN/1-903 E3 ubiquitin-protein ligase Itchy homolog OS=Homo sapiens OX=9606 GN=ITCH PE=1 SV=2 MSDSGSQL-G-------------------SMG-SLTM----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------KS--QLQITVISA---------------------------KLK ENKKNWFG-PSP------------------------------------------------------------ --YVE-----VTVDG------------------------------------------------QSKKTEK-- CNNTNSPKWKQP-LTVIVTPVS-KLHFRVWSH------------QTLKSD-----------V---------- ----------------------LLGTA------------------A-------------------------- ----------------------------------------------L------------------------- --------------DIYETLKSNNM---------------KL-EEVVVTLQLG------------------- ------------------G-DKEPT----------------------------------E-TIGD---L--- ------------------------------------S-----------------------ICLDGLQLESEV VTNGETT------------------------------------------CSENGVSLCL------------- ----------------------------------P------R-----------------------------L ECN-----------------------------------------------SAISA----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------HCNLCLP----------------------------------------------- ------------------------------------------------------------------GLSDSP ISASRV---------AGFTG-----------------------------------ASQNDDGS--------- ------------------------------------------------------------------------ --------------------------RSKDETRV-------STNG----SDDPEDAGAGENRRVSGNNSPSL ---------SNGGFKPS-------------------------------------------------RPPRPS ----------------RPPPPTP------------------------------------------------- ---------------------------------------------------RRPASVNGSPSATSESDGSST GS-----------------LPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNP--VT-------------- ------------------------------QAPLPPGWEQ------------------RVDQH--------- ------------------------GRVYYVDHVEKRTTWDRPE----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------P-----------LPPGWERRVD-------------------- -NMGRIY----YVD-----HFTRTTT-WQ------------------------------------------- ----------------------------------------------------------R------------- -------------------------------PTLES-V---------------------RN----------- -----------------------------------------------------------YEQ---------- -------------------W-QLQRS----------------------------------------QLQGAM QQFNQRFI-----YGNQ------------------------DLFA--------------------------- ------TS---QSKEFDP-----------LGPLPP-----------G------------------------- --------------------------------W-----------------------EKRTD-SNG------- ---RV----YFVNHN---------TRITQWEDPRSQ---GQ------------L-N---------------- ----EKP-LP------------------EGWE-----MR-F------------------------------- -------------TV-------------DGIPYFVD------------------------------------ -------------------------HNRR------------------------------------------- -----------TTTY------IDPRTGKSA------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------LDN G-----------------PQIA---------------------YVRDFKAKVQYFRFW-------------- ------C----------QQ---------LAMPQHIKIT---------------------------------- ---------VTRKTLFEDSFQQI---MSF----SPQD-L------R-RRLWVIFP-----GEEGLDYGGVAR EWFFLLSHEVLNPM-------YCLFEYAGKDNY-----CLQINPASY--I-NPDHLKYFRFIGRFIAMALFH GK-------FIDTGFSLPFYKRILNKP--------------V-----GL-KDLESIDPEFYNSLI-WVKE-- NNIE---ECDLEMYFSVD---K-EILGEI-KSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAF FEGFNEILPQQYLQ-YFDAKELEVLLCGMQ-EIDLNDWQRHAIYRH--YARTSKQIMWFWQFV-KEIDNEKR MRLLQFVTGTCRLPVGGFADLM--------------------GSN---GPQKFCIEKVG--KENWLPRSHTC FNRLDLPPYKSYEQLKEKLLFAIEE-TEGFGQ------E >sp|Q96PU5|NED4L_HUMAN/1-975 E3 ubiquitin-protein ligase NEDD4-like OS=Homo sapiens OX=9606 GN=NEDD4L PE=1 SV=2 MATGLGEPVY-------------------GLS-EDEG------------------E---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------SR--ILRVKVVSG---------------------------IDL -AKKDIFGASDP------------------------------------------------------------ --YVK-----LSLYVADEN---------------------------------R--------ELALVQTKT-- IKKTLNPKWNEE-FYFRVNPSNHRLLFEVFDE------------NRLTRD-----------D---------- ----------------------FLGQV------------------DV------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------PLSHLPTED------------- ----------------------------------P------T-----------------------------M ERPYTF------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------KDFLLRPR SHKSRV------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------KGF-------LR---------------------------LK ---------MAYM----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------PKNGGQ DEENSDQRDDMEHGWEVVDSND---------SASQH-----------------QEELP-------------- ------------------------------PPPLPPGWEE------------------KVDNL--------- ------------------------GRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH ISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQF SSLIQREPSSRLRSCSVTDAVAEQGHLPP--------------------------------PSAPAGRARSS TVTGGEE------------P--TPSV--A----YVHTTP--------------------------------- ------------------------------G-----------LPSGWEERKD-------------------- -AKGRTY----YVN-----HNNRTTT-WT------------------------------------------- ----------------------------------------------------------R------------- -------------------------------PIMQL-A---------------------ED----------- -----------------------------------------------------------GAS---------- -------------------G-SA--T--------------NSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAK DSPVRRAVKDTLSN---------------------------------------------------------- -------P---QSPQPSPYNSPKPQHKVTQSFLPP-----------G------------------------- --------------------------------W-----------------------EMRIA-PNG------- ---RP----FFIDHN---------TKTTTWEDPRLK---FPVHMRSKTSLN-PN-D---------------- ----LGP-LP------------------PGWE-----ER-I------------------------------- -------------HL-------------DGRTFYID------------------------------------ -------------------------HNSK------------------------------------------- -----------ITQW------EDPRLQNP------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------------------AIT G-----------------PAVP---------------------YSREFKQKYDYFRKK-------------- ------LK---------KP---------ADIPNRFEMK---------------------------------- ---------LHRNNIFEESYRRI---MSV----KRPDVL------K-ARLWIEFE-----SEKGLDYGGVAR EWFFLLSKEMFNPY-------YGLFEYSATDNY-----TLQINPNSG--LCNEDHLSYFTFIGRVAGLAVFH GK-------LLDGFFIRPFYKMMLGKQ--------------I-----TL-NDMESVDSEYYNSLK-WILE-- NDPT---E--LDLMFCID---E-ENFGQT-YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAF LEGFTELLPIDLIK-IFDENELELLMCGLG-DVDVNDWRQHSIYKNG-YCPNHPVIQWFWKAV-LLMDAEKR IRLLQFVTGTSRVPMNGFAELY--------------------GSN---GPQLFTIEQWG--SPEKLPRAHTC FNRLDLPPYETFEDLREKLLMAVEN-AQGFEGV-----D >sp|Q9H0M0|WWP1_HUMAN/1-922 NEDD4-like E3 ubiquitin-protein ligase WWP1 OS=Homo sapiens OX=9606 GN=WWP1 PE=1 SV=1 MATASPRS-D-------------------TSN-NHSG----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------RL--QLQVTVSSA---------------------------KLK -RKKNWFG-TAI------------------------------------------------------------ --YTE-----VVVDG------------------------------------------------EITKTAK-- SSSSSNPKWDEQ-LTVNVTPQT-TLEFQVWSH------------RTLKAD-----------A---------- ----------------------LLGKA------------------T-------------------------- ----------------------------------------------I------------------------- --------------DLKQALLIHNR---------------KL-ERVKEQLKLS------------------- ------------------LENKNGI----------------------------------A-QTGE---L--- ------------------------------------T-----------------------VVLDGLVIEQEN ITNCSSSPTIEIQENGDALHENG--------------EPSARTTARLAVEGTNGIDNHV------------- ----------------------------------P------T------------------------------ -----------------------------------------------------STL---------------- -------------------------------------------------VQNSCCSYV-------------- -----------------------------------VNG---------------------------------- ----------------D------------------------------------------------------- -----------NTPSSPSQ----------------------------------------------------- ------------------------------------------------------------------------ -----------------VAA-----------------------------------RPKNTPA---------- ------------------------------------------------------------------------ ------------------------------PKPL-------AS---------------------------EP ---------ADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTS ----------------AELESEA------------------------------------------------- ---------------------------------------------------R----------SILEPDTSNS RSSSA-------FEAAKSRQPD---------GCMDPV------RQQSGNA-------N-------------- ------------------------------TETLPSGWEQ------------------RKDPH--------- ------------------------GRTYYVDHNTRTTTWERPQ----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------P-----------LPPGWERRVD-------------------- -DRRRVY----YVD-----HNTRTTT-WQ------------------------------------------- ----------------------------------------------------------R------------- -------------------------------PTMES-V---------------------RN----------- -----------------------------------------------------------FEQ---------- -------------------W-QSQRN----------------------------------------QLQGAM QQFNQRYL-----YSAS------------------------------------------------------- -------M---LAAENDP-----------YGPLPP-----------G------------------------- --------------------------------W-----------------------EKRVD-STD------- ---RV----YFVNHN---------TKTTQWEDPRTQ---GL------------Q-N---------------- ----EEP-LP------------------EGWE-----IR-Y------------------------------- -------------TR-------------EGVRYFVD------------------------------------ -------------------------HNTR------------------------------------------- -----------TTTF------KDPRNGKSS------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------V-TKG G-----------------PQIA---------------------YERGFRWKLAHFRYL-------------- ------C----------QS---------NALPSHVKIN---------------------------------- ---------VSRQTLFEDSFQQI---MAL----KPYD-L------R-RRLYVIFR-----GEEGLDYGGLAR EWFFLLSHEVLNPM-------YCLFEYAGKNNY-----CLQINPAST--I-NPDHLSYFCFIGRFIAMALFH GK-------FIDTGFSLPFYKRMLSKK--------------L-----TI-KDLESIDTEFYNSLI-WIRD-- NNIE---ECGLEMYFSVD---M-EILGKV-TSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAF LDGFNEVVPLQWLQ-YFDEKELEVMLCGMQ-EVDLADWQRNTVYRH--YTRNSKQIIWFWQFV-KETDNEVR MRLLQFVTGTCRLPLGGFAELM--------------------GSN---GPQKFCIEKVG--KDTWLPRSHTC FNRLDLPPYKSYEQLKEKLLFAIEE-TEGFGQ------E >sp|Q9UII4|HERC5_HUMAN/1-1024 E3 ISG15--protein ligase HERC5 OS=Homo sapiens OX=9606 GN=HERC5 PE=1 SV=2 MERRSRRK-S-------------------RRNG-RSTAGK------------AAATQPAKS-------PGAQ -LW---LFPS-AAGL------------------HRAL---------------LRRVEVT----RQ------- --------LCCSPGRLAVLERGGAGVQ---------VHQLL------------------------AGSGGA- ------------------------------------------------------------------------ -------RTPKC------------------------------------------------------------ --IKLGKNMKIHSVDQ----------------------------------------------GAEHMLIL-- SSDGKPFEYDNY-SMK-----------------------------------------------HL------- -----RFESILQEKKIIQITCGDYHSL------------------A-------------------------- ----------------------------------------------LSKGGEL------------------F AWGQNLH-------G-------------QL--GVGRKFP--S------------------------------ -----------------------TTT----PQIVE-HLAGVP-LAQI------------S-AGE-------- ---------------------------------------AHSMA----------------LSMSGNIYSW-- ------------------------------------------------------------------GKNECG -------------------------QLGLGHTE---SKDDPSLI--------------------EG-----L DN-------------------------------------------------------QKVEFVACG------ ----GSHSALLTQDGL--LFTFGAGKHGQLGHN--------------------STQNELRP----------- -----------------CLVAE-------------------------------------------------- ------------------------------------------------LVGYRVT----------------- -----QIACGRW----------------------------------------------------HTLAYVSD LGKVFSFGSGKD------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------GQL ---------GNG------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------GT---------------------------- --------------------------------------RDQLMPLP---------VKVSSSEELKLESHTSE KELIMIAGGNQSILLWIKKENSY-------VNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFSSPA CLTGSFLRKRR---------------------TTEMMPVYLDLNKARNIFKELTQK-D--WITNMITTCL-- -KDNLLKRLP---FHSPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQ--------------- -SSLV----------LEEYWATLQESTFS----------------------------------------KLV QMFKTAVI---------------------------------------------------------------- -------------------------------CQLDY-WDE----S--------------------------- ---------------------------------A--------------------------E-ENGNVQALLE MLKKL----HRVNQV-----------------------------------K--------------------- -----CQ-LPE------------SIFQV----------D-E------------------------------- -------------LLHRLNFFVEVC-----RRYLWK------------------------------------ -------------------------MTVD------------------------------------------- -----------ASEN------VQC------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------CVI F-----------------SHFP---------------------FIFNNLSKIKLLHTDTLLKIESKKHKAYL RSAAIEEE---------RE-SE------FALRPTFDLT---------------------------------- ---------VRRNHLIEDVLNQL---SQF----ENED-L------R-KELWVSFS-----GEIGYDLGGVKK EFFYCLFAEMIQPE-------YGMFMYPEGAS------CMWFPVKP-----KFE-KKRYFFFGVLCGLSLFN CN-------VANLPFPLALFKKLLDQM--------------P-----SL-EDLKELSPDLGKNLQ-TLLD-- DEGDNFE-----EVFYIH---F-NVHWDR-NDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEF RRGFYKMCDEDIIK-LFHPEELKDVIVGNT-DYDWKTFEKNARYEPG-YNSSHPTIVMFWKAF-HKLTLEEK KKFLVFLTGTDRLQMKDLNNMK--------------------IT--------FCCPESW--NERDPIRALTC FSVLFLPKYSTMETVEEALQEAINN-NRGFG-------- >sp|Q9P2P5|HECW2_HUMAN/1-1572 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens OX=9606 GN=HECW2 PE=1 SV=2 MASSAREH-L-------------------LFV-RRRN-------------------PQMRY-TLSPENLQSL AAQS--SMPE-NMTLQRANSDTDLV----TSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYH IDE----NSPANFWDS--KNRGVTGTQ---------KGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRAT TPCITVKNPAV-MMGAEGMEGGASGNLHSRKLVSFTLSDLRA---------------------------VGL --KKGMFFNPDP------------------------------------------------------------ --YLK-----MSIQPGKKS---------------------------------SFPTCAH--HGQERRSTI-- ISNTTNPIWHREKYSFFALLTD-VLEIEIKDK------------FAKSRPIIK--------R---------- ----------------------FLGKL------------------T-------------------------- ----------------------------------------------I------------------------- --------------PVQRLLERQAIGDQMLSYNLGRRLP--A-DHVSGYLQFK------------------- ------------------VEVTSSVHEDASPEAVG-TILGVN-SVNGDLGSPSDDEDMPG-SHHDSQVCSNG PVS---------------------------EDSAADGTPKHSFR----------------TS-STLEIDTEE LTSTSSRTS--------PPRGRQDSLNDYLDAIEHNGH--------------------S------------- ----------------------RPGTATCSERSMG---ASPK-----------------------------L RSS-----------------------------------------------FPTDTRLNAMLHIDSDEEDHEF QQDLG-YPSSLEEEGG--LIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKP----------- -----------------ENLPE-------------------------------------------------- ------------------------------------------------LAESSLPAGPAPEEGEGGPEPQPS ADQGSAELCGSQ----------------------------------------------------EV------ ------------------------------------------------------------------------ --------------------------------------------------------------------DQPT S----------------------------------------------------------------------- ------------------------GADTGTS--D-------ASGG----------------------SRRAV ---------SETESLDQGS------EPSQVSSETEPSDP-----------------------------ARTE ----------------SVSEASTRPEGESDLECADSSCNE-------------------------------- --SVTTQLSSVDTRCSSLESARFPETPAFSSQEEE---DGACAAEPTSSGPA----------EG-------- ---------------------------------------------------------SQESVCTAGSLPVVQ ------------VPSGEDEGPGAESATVPDQEELGEVWQR------------------RGSLE--------- ------------------------GAAAAA----------------------ES---PPQEEGSA------- ------------------------------------------------------------------------ ----------------------------------------------------------------GEAQGTCE GATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDE--------------------------------- ------------------------------A-----------LPPNWEARID-------------------- -SHGRIF----YVD-----HVNRTTT-WQ------------------------------------------- ----------------------------------------------------------R------------- -------------------------------PTAPP-A---------------------PQ----------- -----------------------------------------------------------VLQ---------- -------------------R-----S----------------------------------------NSIQQM EQLNRRYQ-----SIRR------------------------TMTNERPEE---------------------- ----NTNA------------------------I-------------DGAGEEADFHQASADFRRENILPHST SRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQH-NRD------- ---LV----GFLNM------------------------------------F-AN-K---------------- ----QLE-LP------------------RGWE-----MK-H------------------------------- -------------DH-------------QGKAFFVD------------------------------------ -------------------------HNSR------------------------------------------- -----------TTTF------IDPRLPLQSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSST FNTVSRPQY-QDMVPVAYNDKIVA--------FLRQPNIFE--ILQERQPDLTRNHSLREKIQFIRTEGT-- -------PGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPVSS---PQNSPG-TQR-ANA R-----------------APAP---------------------YKRDFEAKLRNFYRK-------------- ------LE---------TK-GY------GQGPGKLKLI---------------------------------- ---------IRRDHLLEDAFNQI---MGY----SRKD-L------QRNKLYVTFV-----GEEGLDYSGPSR EFFFLVSRELFNPY-------YGLFEYSANDTY-----TVQISPMSA--F-VDNHHEWFRFSGRILGLALIH QY-------LLDAFFTRPFYKALLRIL--------------C-----DL-SDLEYLDEEFHQSLQ-WMKD-- NDIH---DI-LDLTFTVN---E-EVFGQI-TERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESL VRGFYEVVDARLVS-VFDARELELVIAGTA-EIDLSDWRNNTEYRGG-YHDNHIVIRWFWAAV-ERFNNEQR LRLLQFVTGTSSIPYEGFASLR--------------------GSN---GPRRFCVEKWG--KITALPRAHTC FNRLDLPPYPSFSMLYEKLLTAVEE-TSTFGL------E >sp|Q5U5R9|HECD2_HUMAN/1-776 Probable E3 ubiquitin-protein ligase HECTD2 OS=Homo sapiens OX=9606 GN=HECTD2 PE=1 SV=2 MSEAVRVP-S------------------------P----------------------------------ATP -LV---V----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------AAP----------------------------------------------APEERKGKES EREKLPPIVSAG------------------------------------------------------------ --------------------AGA------------------------------------------------- ----------------------------------------------------------------------TA GLDRGA-------KG-------------QI--STFSSFI--S------------------------------ -----------------------AVS----PKK--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------EAAE---NRSSPAHL--------------------VFPNIKNV R----------------------------------------------------------------------- -----------------------------------------------------------EPPPICLDVRQKQ RTSMDASSSEMKAPVLPEPILPIQPKTVKDFQEDV------------------------------------- ------------------------------------------------------------------------ -----EKVKSSG----------------------------------------------------DWKAVHDF YLTTFDSF---------------------------------------------------------------- --PEL------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --NAAFKKD---ATASFNTI----------------EDSGINAKFVNAVYDTLLNTPQ--DVQKTVLKGI-- -INSLLREWK----GPRTKDDLRAYFILLQNPQFNNTSTYVIYAHL-LRQIATLVEA--------------- -DHHF----------LVHWFKKLSQKRFK----------------------------------------QLV ERLLQFIS---------------------------------------------------------------- -------------------------------LRLFPAKPEE-FPP--------------------------- ---------------------------------I--------------------------TKCSWWIPSAAK VLALL----NTANNLV-------------------------------------------------------- -----------------------------------------------------------------------H PPLIPYTDFYNSTLDHI-DLMEEYH-----TWQNFG------------------------------------ -------------------------NSHR------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------FS F-----------------CQYP---------------------FVISVAAKKIIIQRDSEQQMINIARQSLV DK----VS---------RRQRP------DMNILFLNMK---------------------------------- ---------VRRTHLVSDSLDEL---TR-----KRAD-L-------KKKLKVTFV-----GEAGLDMGGLTK EWFLLLIRQIFHPD-------YGMFTYHKDSH------CHWFSSFK------CDNYSEFRLVGILMGLAVYN SI-------TLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNV-----TV-DDLCQIMPELAHGLS-ELLSHE GNVE---ED-FYSTFQVF---Q-EEFGII-KSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAF YYGFHSVCASNALM-LLRPEEVEILVCGSP-DLDMHALQRSTQYD-G-YAKTDLTIKYFWDVV-LGFPLDLQ KKLLHFTTGSDRVPVGGMADLN------------------------------FKISKNE-TSTNCLPVAHTC FNQLCLPPYKSKKDLKQKLIIGISN-SEGFGLE------ >sp|Q7Z3V4|UBE3B_HUMAN/1-1068 Ubiquitin-protein ligase E3B OS=Homo sapiens OX=9606 GN=UBE3B PE=1 SV=3 MFTLSQTS-RAWF----------------------------I----DRARQAREERLVQKERERAAVVIQAH -VRSFLCRSRLQRDIRREIDDF-FKADDPESTKRSAL----CI--FKIARKLLFLFRIKEDNERFEKLCRSI LSSMDAENEPKVWY------VSLACSKDLTLLWIQQIKNILWYCCDFLKQL--------------------- -----------------------------------------KPEILQDSR--------------------LI T----------------------------------------------------------------------- -LYLT-----MLVTFTDTS---------------------------------TWKILRG--KGESLRPAM-- NHICANIMGHLNQHGFYS-----VLQILLTR------------GLARPRPCLS--------K---------- ------------------------GTL------------------T-------------------------- ----------------------------------------------A------------------------- --------------AFS-L--------------AL------------------------------------- ---------------------------------------RPV-IAAQ------------F-S---------- ------------------------------------------------------------------------ --------------------------------------------------------------DNLIRPFLIH IMSVP------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------ALVT----------------- -----HLSTVTP----------------------------------------------------ERLT---- ------VLESHDML---------------------------------------------------------- RKFI---------------IFLRDQDRCRDVCESLEGCHTLCLMGNLLHLGSLSPRVL---------EEETD GFVS-------------------------------------------------------------------- ----LLTQT--------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------LC-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------YCRKYVSQKKSNLTHWHP------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------VLGWFSQSVDYGLNESMHLITKQLQFLWG VPLIRIF----FCDIL-----SKKLLESQ------------------------------------------- ----------------------------------------------------------E------------- -------------------------------PAHA------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------QPASPQNVLPVKSLLK RAFQKSAS---VRNI-----------------LRP-----------V------------------------- --------------------------------G-----------------------GKRVD-SAE------- ---VQKVCNICVLYQ---------TSLTTLTQIRLQILTGL------------TYL---------------- ----DDL-LP------------------KLWA------FIC------------------------------- -----------ELGPH------------GGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVY EEQI----------------SFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERD CRRRFTPEDHWLRK---------------------------------------------------------- ------------------------------------------------------------------------ ---------DL--------------------------------------------------------KPSVL FQELDRDRKRAQLI---LQYIP---------------------HVIPHKNRVLLFRTM-------------- ------VTKEKEKLGLVETSSA------S--PHVTHIT---------------------------------- ---------IRRSRMLEDGYEQL---RQL----SQHA-M------K-GVIRVKFVNDLGVDEAGIDQDGVFK EFLEEIIKRVFDPA-------LNLFKTTSGDE------RLYPSPTSY--I-HENYLQLFEFVGKMLGKAVYE GI-------VVDVPFASFFLSQLLGHH--------------HSVFYSSV-DELPSLDSEFYKNLT-SIKRYD GDIT---D--LGLTLSYD---E-DVMGQL-VCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAAL ISGFRSIIKPEWIR-MFSTPELQRLISGDNAEIDLEDLKKHTVYYGG-FHGSHRVIIWLWDILASDFTPDER AMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSV---LRGFFTIRKRE-P-GGRLPTSSTC FNLLKLPNYSKKSVLREKLRYAISM-NTGFEL------S >sp|Q5GLZ8|HERC4_HUMAN/1-1057 Probable E3 ubiquitin-protein ligase HERC4 OS=Homo sapiens OX=9606 GN=HERC4 PE=1 SV=1 MLCWGNAS-F-------------------GQLG-LGGIDE------------EIVLEPRKS-D---FFINKR -VR---D--V-GCGL------------------RHTV---------------FVL-DDG----TV------- --------YTCGCNDL--GQLGHE--------------------------------------------KSR- ------------------------------------------------------------------------ -------KKPEQ------------------------------------------------------------ --VVALDAQNIVAVSC----------------------------------------------GEAHTLAL-- NDKGQVYAWGLD-SDG-----------------------------------------------QLGLVGSEE CIRVPRNIKSLSDIQIVQVACGYYHSL------------------A-------------------------- ----------------------------------------------LSKASEV------------------F CWGQNKY-------G-------------QL--GLGTDCK--K------------------------------ -----------------------QTS----PQLLK-SLLGIP-FMQV------------A-AGG-------- ---------------------------------------AHSFV----------------LTLSGAIFGW-- ------------------------------------------------------------------GRNKFG -------------------------QLGLNDEN---DRYVPNLL--------------------KS-----L RS-------------------------------------------------------QKIVYICCG------ ----EDHTAALTKEGG--VFTFGAGGYGQLGHN--------------------STSHEINP----------- -----------------RKVFE-------------------------------------------------- ------------------------------------------------LMGSIVT----------------- -----EIACGRQ----------------------------------------------------HTSAFVPS SGRIYSFGLGGN------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------GQL ---------GTG------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------ST---------------------------- --------------------------------------SNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKR IFSGGDQ----SFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSG CLNGSFLAVSNDD----------------HYRTGT-RFSGVDMNAARLLFHKLIQP-DHPQISQQVAASL-- -EKNLIPKLT---SSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKA--------------- -PLKV----------LENWWSVLEPPLFL----------------------------------------KIV ELFKEVVV---------------------------------------------------------------- -------------------------------HLLKL-YKIG-IPPSE------------------------- --------------------------------RR--------------------------I-FNSFLHTALK VLEIL----HRVNEK-----------------------------------M--------------------- -----GQIIQY------------DKFYI----------H-E------------------------------- -------------VQELIDIRNDYINWVQQQAYGMD------------------------------------ -------------------------VNHG------------------------------------------- -----------LTEL------ADI------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------PVT I-----------------CTYP---------------------FVFDAQAKTTLLQTDAVLQMQMAIDQAHR QNVSSLF----------LP-VI------ESVNPCLILV---------------------------------- ---------VRRENIVGDAMEVL---RKT----KNID-Y------K-KPLKVIFV-----GEDAVDAGGVRK EFFLLIMRELLDPK-------YGMFRYYEDSR------LIWFSDKT-----FED-SDLFHLIGVICGLAIYN CT-------IVDLHFPLALYKKLLKKK--------------P-----SL-DDLKELMPDVGRSMQ-QLLD-- YPEDDIEET-FCLNFTIT---V-ENFGAT-EVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAF HAGFHKVCGGKVLL-LFQPNELQAMVIGNT-NYDWKELEKNTEYKGE-YWAEHPTIKIFWEVF-HELPLEKK KQFLLFLTGSDRIPILGMKSLK--------------------L----------VIQSTG-GGEEYLPVSHTC FNLLDLPKYTEKETLRSKLIQAIDH-NEGFSL------I >sp|O15033|AREL1_HUMAN/1-823 Apoptosis-resistant E3 ubiquitin protein ligase 1 OS=Homo sapiens OX=9606 GN=AREL1 PE=1 SV=3 MFYVIGGI-TVSVV-----------AFFFTI----KFLFELAARVVSFLQNEDRERRGDRT-------IYDY -VRGNY-------LDPRS--------------------------C-------KVSWDWKDPYEVGHS----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------MAFRVHLFYKNGQPFPAHR----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------P--------------VGLRVH--I-SHV---------------------E---- ------------------------------------LAVEIP-VTQE------------V-LQE-------- ---------------------------------------PNSNVVKVAFTVRKAGRYEITVKLGGLNV--AY SPYY------------KI----------------------------------FQPGMVVPSKTKIVCHFSTL ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----VLTCGQP----------------------------------------------------HTLQIVPR DE---------------------------------------------------------------------- -----------------------------------------------YDNPTNN--SM---------SLRDE HNYTLSIHELGPQEE-------------------------------------ESTGVSFEKSVTSNRQTFQV FLRLTLHSR--------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------GCFHACIS--YQNQPI NNGE-------FD----IIVLSEDEKN--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------IVERNVSTSG-------- --------------------VSIY------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------FEAYLYNATNCSSTP-WH------------------------------------------- ----------------------------------------------------------L------------- -------------------------------PPMHM-T---------------------SS----------- -------------------------------------------------------------Q---------- ------------------------------------------------------------------------ ----------------------------------------RRPSTAVDEEDEDSPSECHTPEKVKK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------PKKVYCY VSPK----------------Q-----------------------FSVKEFYLKII----------------- ------------------------------------------------------------------------ ---------------------------------PWRLYTFRVCPG-----------------------TKFS YLGPDPVHKLLTLVVDDGI----------------------------------QP----PVELSCKER---N I-------LAATFIRSLHKNIG---------------------GSETFQDKVNFFQRE-------------- ------LR---------QVHMK------RP-HSKVTLK---------------------------------- ---------VSRHALLESSLKAT---RNF----SISD-W------S-KNFEVVFQ-----DEEALDWGGPRR EWFELICKALFDTT-------NQLFTRFSDNN------QALVHPNPNRPA-H-LRLKMYEFAGRLVGKCLYE SSLGGAYKQLVRARFTRSFLAQIIGLR--------------M-----HY-KYFETDDPEFYKSKVCFIL--N NDMS---E--MELVFAEE---KYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHF LKGLNELVPENLLA-IFDENELELLMCGTG-DISVSDFKAHAVVVGGSWHFREKVMRWFWTVV-SSLTQEEL ARLLQFTTGSSQLPPGGFAALCPS----------------------------FQIIAAP-T-HSTLPTAHTC FNQLCLPTYDSYEEVHRMLQLAISEGCEGFGM------L >sp|Q8IVU3|HERC6_HUMAN/1-1022 Probable E3 ubiquitin-protein ligase HERC6 OS=Homo sapiens OX=9606 GN=HERC6 PE=1 SV=2 MYFCWGAD-S-------------------RELQRRRTA---------------------GS-------PGAE -LL-----QA-ASGE------------------RHSL---------------LL-LTNH----RV------- --------LSCGDNSR--GQLGRRGAQ---------RG---------------------------------- ------------------------------------------------------------------------ -------ELPEP------------------------------------------------------------ --IQALETLIVDLVSC----------------------------------------------GKEHSLAV-- CHKGRVFAWGAG-SEG-----------------------------------------------QLGIGEFKE ISFTPKKIMTLNDIKIIQVSCGHYHSL------------------A-------------------------- ----------------------------------------------LSKDSQV------------------F SWGKNSH-------G-------------QL--GLGKEFP--S------------------------------ -----------------------QAS----PQRVR-SLEGIP-LAQV------------A-AGG-------- ---------------------------------------AHSFA----------------LSLCGTSFGW-- ------------------------------------------------------------------GSNSAG -------------------------QLALSGRNVPVQSNKPLSV--------------------GA-----L KN-------------------------------------------------------LGVVYISCG------ ----DAHTAVLTQDGK--VFTFGDNRSGQLGYS--------------------PTPEKRGP----------- -----------------QLV-E-------------------------------------------------- ------------------------------------------------RIDGLVS----------------- -----QIDCGSY----------------------------------------------------HTLAYVHT TGQVVSFGHGPS------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------DTS ---------KPT------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------HP---------------------------- --------------------------------------EALTENFD---------ISCLISAEDFVDVQVKH IFAGTYANFVTTHQDTSSTRAPG-------KTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPA CLTASFLKKRG---------------------TGETTSIDVDLEMARDTFKKLTKK-E--WISSMITTCL-- -EDDLLRALP---CHSPHQEALSVFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQ--------------- -SLQV----------LKKCWAFLQESSLN----------------------------------------PLI QMLKAAII---------------------------------------------------------------- -------------------------------SQLLH-QTK----T--------------------------- ---------------------------------E--------------------------Q-DHCNVKALLG MMKEL----HKVNKA-----------------------------------N--------------------- -----CR-LPE------------NTFNI----------N-E------------------------------- -------------LSNLLNFYIDRG-----RQLFRD------------------------------------ -------------------------NHLI------------------------------------------- -----------PA-E------TPS------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------PVI F-----------------SDFP---------------------FIFNSLSKIKLLQADSHIKMQMSEKKAYM LMHETILQ---------KK-DE------FPPSPRFILR---------------------------------- ---------VRRSRLVKDALRQL---SQA----EATD-F------C-KVLVVEFI-----NEICPESGGVSS EFFHCMFEEMTKPE-------YGMFMYPEMGS------CMWFPAKP-----KPE-KKRYFLFGMLCGLSLFN LN-------VANLPFPLALYKKLLDQK--------------P-----SL-EDLKELSPRLGKSLQ-EVLD-- DAADDIG-----DALCIR---F-SIHWDQ-NDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEF QRGFYRVCEKEILR-HFYPEELMTAIIGNT-DYDWKQFEQNSKYEQG-YQKSHPTIQLFWKAF-HKLTLDEK KKFLFFLTGRDRLHARGIQKME--------------------IV--------FRCPETF--SERDHPTSITC HNILSLPKYSTMERMEEALQVAINN-NRGFVSPML-TQS >sp|Q15034|HERC3_HUMAN/1-1050 Probable E3 ubiquitin-protein ligase HERC3 OS=Homo sapiens OX=9606 GN=HERC3 PE=1 SV=1 MLCWGYWS-L-------------------GQPG-ISTNLQ------------GIVAEPQVC-G---FISDRS -VK---E--V-ACGG------------------NHSV---------------FLL-EDG----EV------- --------YTCGLNTK--GQLGHE--------------------------------------------REG- ------------------------------------------------------------------------ -------NKPEQ------------------------------------------------------------ --IGALADQHIIHVAC----------------------------------------------GESHSLAL-- SDRGQLFSWGAG-SDG-----------------------------------------------QLGLMTTED SVAVPRLIQKLNQQTILQVSCGNWHCL------------------A-------------------------- ----------------------------------------------LAADGQF------------------F TWGKNSH-------G-------------QL--GLGKEFP--S------------------------------ -----------------------QAS----PQRVR-SLEGIP-LAQV------------A-AGG-------- ---------------------------------------AHSFA----------------LSLSGAVFGW-- ------------------------------------------------------------------GMNNAG -------------------------QLGLSDEK---DRESPCHV--------------------KL-----L RT-------------------------------------------------------QKVVYISCG------ ----EEHTAVLTKSGG--VFTFGAGSCGQLGHD--------------------SMNDEVNP----------- -----------------RRVLE-------------------------------------------------- ------------------------------------------------LMGSEVT----------------- -----QIACGRQ----------------------------------------------------HTLAFVPS SGLIYAFGCGAR------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------GQL ---------GTG------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------HT---------------------------- --------------------------------------CNVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQ IFSGGDQ----TFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSSAA CWNGSFLEKKIDE----------------HFKTSP-KIPGIDLNSTRVLFEKLMNS-QHSMILEQILNSF-- -ESCLIPQLS---SSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTN--------------- -PSKV----------LDNWWSQVCPKYFM----------------------------------------KLV NLYKGAVL---------------------------------------------------------------- -------------------------------YLLRG-RKTF-LIP--------------------------- ---------------------------------V--------------------------L-FNNYITAALK LLEKL----YKVNLK-----------------------------------V--------------------- -----KH-VEY------------DTFYI----------P-E------------------------------- -------------ISNLVDIQEDYLMWFLHQA-GMK------------------------------------ -------------------------AR--------------------------------------------- ------------PSI------IQD------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------TVT L-----------------CSYP---------------------FIFDAQAKTKMLQTDAELQMQVAVNGANL QNVFMLLT---------LE-PL------LARSPFLVLH---------------------------------- ---------VRRNNLVGDALREL---SIH----SDID-L------K-KPLKVIFD-----GEEAVDAGGVTK EFFLLLLKELLNPI-------YGMFTYYQDSN------LLWFSDTC-----FVE-HNWFHLIGITCGLAIYN ST-------VVDLHFPLALYKKLLNVK--------------P-----GL-EDLKELSPTEGRSLQ-ELLD-- YPGEDVEET-FCLNFTIC---R-ESYGVI-EQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAF SSGFLKVCGGKVLE-LFQPSELRAMMVGNS-NYNWEELEETAIYKGD-YSATHPTVKLFWETF-HEFPLEKK KKFLLFLTGSDRIPIYGMASLQ--------------------I----------VIQSTA-SGEEYLPVAHTC YNLLDLPKYSSKEILSARLTQALDN-YEGFSL------A